Registered Nurse - Night Shift Inpatient Opportunities – RN

Jacksonville, Florida

Explore Night Shift RN opportunities across Mayo Clinic in Florida, including Care Transition Unit, Hematology/Oncology/Medical, Pulmonary/Medical, Medical, Neuro, Critical Care, Cardiology and Transplant/Medical. Mayo Clinic is an academic medical center.

Posted Jul 13

Shift and hours: Nights: full-time, modified, part-time or PRN · Typically 6:45 PM to 7:15 AM
Unit and setting: Night units: Care Transition, Hematology/Oncology/Medical, Pulmonary/Medical, Medical, Neuro, Critical Care, Cardiology, Transplant/Medical · Hospital
License: RN license Current RN license by applicable state requirements.Current RN license for the state
Term: Permanent

Do you qualify?

License: Current RN license for the state Current RN license by applicable state requirements.
Certification: BLS from American Heart Association or American Red Cross Maintains Basic Life Support (BLS) competency from one of the following programs: American Heart Association or American Red Cross.
Education: Graduate of a nursing program Graduate of a nursing program.
Education: Associate-degree RNs who started on or after April 1, 2020 need a BSN within five years of RN start
Education: Associate-degree RNs who started before April 1, 2020 need a BSN under the program rule in place at hire
Also asks: Computer skills Computer skills required, prior experience with electronic medical record systems preferred.
Also asks: Ability to work days, evenings, nights, holidays, weekends and on-call Ability to work flexible hours, which may include days, evenings, nights, holidays, and weekends and on-call.
Also asks: Additional state licensure or specialty certification as the work area requires Additional state licensure(s) and/or specialty certification/training as required by the work area

Preferred

Experience: 1 year RN experience in an applicable care setting, or 1 year LPN experience at Mayo Clinic One year of RN experience in an applicable care setting or one year of LPN experience at Mayo Clinic is preferred.
Also asks: Prior electronic medical record experience

What it pays

Night differential: All night shift positions include competitive shift differentials in addition to base pay. All night shift positions include competitive shift differentials in addition to base pay.
Extra pay: Shift differential on top of base pay for night shiftsNight shift positions
Eligibility: Benefit eligible Benefit Eligible
Pay reviews: Pay rewards experience, education and dedication Mayo Clinic has an innovative nursing compensation model that rewards for experience, education, and dedication to the organization.

Benefits

BenefitsMedical: multiple plan optionsMedical: Multiple plan options.
BenefitsDental: Delta Dental or reimbursement accountDental: Delta Dental or reimbursement account for flexible coverage.
BenefitsVision: affordable plan with national networkVision: Affordable plan with national network.
BenefitsHSA and FSA pre-tax savingsPre-Tax Savings: HSA and FSAs for eligible expenses.
BenefitsCompetitive retirement packageRetirement: Competitive retirement package to secure your future.
BenefitsTuition reimbursementcompetitive tuition reimbursement program

More benefits (5)

BenefitsPension and 403(b)/401(k) matchPension & 403(b)/401(k) Match
BenefitsContinuing medical educationContinuing Medical Education
BenefitsPaid time off and disabilityPaid Time Off & Disability
BenefitsRelocation assistanceRelocation Assistance
Pre-Tax Savings (HSA/FSA)

Posted pay in Florida

The role and schedule

Day to day: Patient/family education and transitions of care The registered nurse (RN) is accountable for the coordination of nursing care, including direct patient care, patient/family education and transitions of care.
Day to day: Informal leadership and quality improvement efforts The RN provides leadership through activities such as preceptor role, informal leadership roles, and quality improvement efforts.
Weekends: Every other or every third weekend Variable shifts may include every other or every third weekend.
On call: Holidays, weekends and on-call may be required
Details: Some employees may be required to drive their personal vehicle as part of their role A subset of employees may be required to drive their personal vehicle as a part of the responsibility of their role.
Details: Job offers are contingent on a post-offer placement assessment including a urine drug screen, immunization review and TB skin testing, if applicable
Details: TN visa sponsorship available This role is eligible for TN sponsorship.

The workplace

Mayo Clinic

Academic Medical Center

Hiring contact: **Recruiter** Jorida Musta **Recruiter** Jorida Musta

3.6 Google rating

Facility profile Employer website

The team behind this role

Hiring contact

Jorida Musta · Recruiter

This posting

Nursing leadership

Ryannon · Chief Nursing Officer

Mayo Clinic

Sources

Source: linkedin.com

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Your fit

Questions to ask

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What should I expect for weekly hours, holiday, and rotation?
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Original listing

Posted on Mayo Clinic’s careers page.

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Registered Nurse - Night Shift Inpatient Opportunities – RN

Job ID 386080Date posted 07/13/2026

Jacksonville, FL
Full Time
Benefit Eligible
Remote: No

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Overview

At Mayo Clinic, you will become a vital member of a dynamic team at one of the world's most exceptional health care institutions. Our Nursing Care Model combines Relationship-Based Care with an evidence-based approach. This allows for a stronger connection between patient and caregiver, and a more individualized, appropriate type of care. You will also discover a culture of teamwork, professionalism and mutual respect, and—most importantly—a life-changing career.

Job Description

CityJacksonville

StateFL

RemoteNO

DepartmentNursing

Why Mayo Clinic

Mayo Clinic is top-ranked in more specialties than any other care provider according to U. S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans (opens in new window) – to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic.

Benefits Highlights

Medical: Multiple plan options.
Dental: Delta Dental or reimbursement account for flexible coverage.
Vision: Affordable plan with national network.
Pre-Tax Savings: HSA and FSAs for eligible expenses.
Retirement: Competitive retirement package to secure your future.

Responsibilities

Join a Life-Changing Career Path at Mayo Clinic

Do you enjoy working nights and having the flexibility in your days? Explore night shift opportunities for Registered Nurses (RN) at Mayo Clinic in Florida. You will have the opportunity to connect with our recruitment team and learn more about our culture, our commitment to excellence, and why Mayo Clinic is the No. 1 place to work in Florida.

This isn’t just a career search — it’s your chance to

Explore Night Shift RN opportunities across Mayo Clinic in Florida, including Care Transition Unit, Hematology/Oncology/Medical, Pulmonary/Medical, Medical, Neuro, Critical Care, Cardiology and Transplant/Medical

Join the No. 1 Hospital in Florida and transform healthcare

Become part of a nursing practice model that empowers professional growth, multidisciplinary care, and shared decision-making, contributing to excellent patient care

Learn more about Mayo Clinic’s comprehensive benefits package designed to support your health, well-being, and future: https://jobs.mayoclinic.org/benefits (opens in new window)

The future belongs to those who believe in their dreams. Let us help you take the next step in your nursing career at Mayo Clinic. Apply today!

What to Expect After Applying

Your application will be reviewed by the Mayo Clinic team
You may be contacted for next steps related to Night Shift RN opportunities
You may be asked to provide additional information or participate in interviews

The registered nurse (RN) is accountable for the coordination of nursing care, including direct patient care, patient/family education and transitions of care. The RN supports professional nursing practice across practice settings and across the continuum of care to meet the needs of the patient and family. The RN will function within the Mayo Clinic Nursing Professional Practice Model, which includes accountability for planning, implementing, evaluating and communicating all phases of nursing care for assigned patients.

The ANA Nursing: Scope and Standards of Practice provide a basis for the practice of the RN. The RN provides leadership through activities such as preceptor role, informal leadership roles, and quality improvement efforts. The RN delegates patient care according to skill level, experience, patient acuity, fiscal accountability, and adequacy of resources.

The RN possesses excellent communication skills; is skillful in mentoring and teaching; and may participate on committees or projects. A subset of employees may be required to drive their personal vehicle as a part of the responsibility of their role.

This role is eligible for TN sponsorship. Successful sponsorship will require state licensure and completion of the VisaScreen or equivalent certification.

Qualifications

Graduate of a nursing program.

All entry-level associate degree registered nurses with a RN start date of April 1, 2020 and after must provide documented evidence of program completion of a baccalaureate degree in nursing program within five years from the last day of the month of the RN start date.

All entry-level associate degree registered nurses with a RN start date prior to April 1, 2020 must provide documented evidence of program completion of a baccalaureate degree in nursing program as stipulated by the degree requirement program in place at time of hire.

One year of RN experience in an applicable care setting or one year of LPN experience at Mayo Clinic is preferred.

Excellent communication skills (verbal and written). Experience working in a team environment. Computer skills required, prior experience with electronic medical record systems preferred. Ability to work flexible hours, which may include days, evenings, nights, holidays, and weekends and on-call. Ability to adapt to unpredictable situations within the work setting. Demonstrated leadership, effective communicator, and excellent critical thinking skills.

License or

Certification

Current RN license by applicable state requirements. Maintains Basic Life Support (BLS) competency from one of the following programs: American Heart Association or American Red Cross. Positions that are not on campus may not require current Basic Life Support (BLS) competency as determined by the work area.

Additional state licensure(s) and/or specialty certification/training as required by the work area

Exemption Status

Nonexempt

Compensation Detail

Mayo Clinic has an innovative nursing compensation model that rewards for experience, education, and dedication to the organization. When combined with our competitive tuition reimbursement program, the compensation approach empowers nurses to grow professionally and maximize their earning potential.

Benefits Eligible

Yes

Schedule

Full Time

Hours/Pay Period

Varies

Schedule Details

We offer flexible night shift options, including full-time, modified, part-time, and PRN schedules. Shifts are typically 6:45 PM to 7:15 AM, with variations depending on unit needs. All night shift positions include competitive

shift differentials in addition to base pay.

Weekend Schedule

Variable shifts may include every other or every third weekend. Available schedule options will be discussed during interview.

International Assignment

Site Description

Just as our reputation has spread beyond our Minnesota roots, so have our locations. Today, our employees are located at our three major campuses in Phoenix/Scottsdale, Arizona, Jacksonville, Florida, Rochester, Minnesota, and at Mayo Clinic Health System campuses throughout Midwestern communities, and at our international locations. Each Mayo Clinic location is a special place where our employees thrive in both their work and personal lives. Learn more about what each unique Mayo Clinic campus has to offer, and where your best fit is. (opens in new window)

Equal Opportunity

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, protected veteran status or disability status. Learn more about the "EOE is the Law" (opens in new window). Mayo Clinic participates in E-Verify (opens in new window) and may provide the Social Security Administration and, if necessary, the Department of Homeland Security with information from each new employee's Form I-9 to confirm work authorization.

Recruiter

Jorida Musta

Career Path

Mayo Clinic offers many different nursing career opportunities to meet the needs of nursing professionals with a variety of educational and work experiences.

Whether you have a vocational certificate, or an associate, bachelor's, master's or doctoral degree, Mayo Clinic's multidisciplinary, team-oriented work environment presents opportunities that are rarely experienced elsewhere.

High School Diploma/Vocational Degree

Health Unit Coordinator
Sterile Processing Technician
Patient Care/Nursing Assistant or Technician
Emergency Department Technician

Urology Technician
Licensed Practical Nurse
Medical Assistant
IV Technician
Certified Surgical Technologist

Bachelor's Degree

Certified Surgical Assistant
Clinical Resource Nurse
Nursing Research
Social Worker
Registered Nurse
Nurse Supervisor
Nurse Manager

Graduate Degree

Nursing Education Specialist
Nurse Scientist
Clinical Nurse Specialist
Nurse Practitioner
Certified Registered Nurse Anesthetist
Nurse Leadership
Social Worker

Benefits

•

Pension & 403(b)/401(k) Match

•

Continuing Medical Education

•

Paid Time Off & Disability

•

Relocation Assistance

•

Choose From a Wide Number of Specialties and Settings

[About our location \\ \\ Jacksonville, Florida\\ \\ Learn More\\ \\ ](https://jobs.mayoclinic.org/job_location/jacksonville/registered-nurse-night-shift-inpatient-opportunities-rn/33647/97758628192/681633)

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What's around it?

In Jacksonville, FL

Jacksonville, FLFrom Census ACS 2024.

Living costs about the same as the US average

Median rent: $1,465/mo
Household income: $69,872/yr, all local households, not nurse pay

Life in Jacksonville, FL

NeighborhoodsYoung professionals and many relocating nurses cluster in Riverside/Avondale (about $425K median) for walkable historic streets and King Street/Five Points life, San Marco (about $525K) for restaurants and river access, and Murray Hill (typical values around $228K) for 1940s bungalows, Edgewood Avenue breweries, Community Loaves, and the Murray Hill Theatre at a lower entry than the core historic districts. Southside/Tinseltown (about $345K) and Southside Estates sit about 15 minutes from J. Turner Butler Boulevard and St. Johns Town Center; Arlington (list prices around $253K) offers mid-century homes under oaks and a short hop to Jacksonville University and the beaches. Family-oriented Mandarin (about $398K) and Orange Park/Fleming Island (about $365K) trade suburban lots and schools for a longer downtown run; Nocatee (about $525K) is amenity-heavy master-planned living with CDD costs and distance from downtown. Jacksonville Beach and Atlantic Beach ($685K–$725K) and Ponte Vedra (about $895K) buy coastal or country-club lifestyle at premium prices, hurricane and parking trade-offs, and often high HOA/CDD; Westside (about $285K) and Springfield/Northside (about $245K) are the cheapest and highly variable block by block.

Young professionals and many relocating nurses cluster in Riverside/Avondale (about $425K median) for walkable historic streets and King Street/Five Points life, San Marco (about $525K) for restaurants and river access, and Murray Hill (typical values around $228K) for 1940s bungalows, Edgewood Avenue breweries, Community Loaves, and the Murray Hill Theatre at a lower entry than the core historic districts. Southside/Tinseltown (about $345K) and Southside Estates sit about 15 minutes from J. Turner Butler Boulevard and St. Johns Town Center; Arlington (list prices around $253K) offers mid-century homes under oaks and a short hop to Jacksonville University and the beaches.

Family-oriented Mandarin (about $398K) and Orange Park/Fleming Island (about $365K) trade suburban lots and schools for a longer downtown run; Nocatee (about $525K) is amenity-heavy master-planned living with CDD costs and distance from downtown. Jacksonville Beach and Atlantic Beach ($685K–$725K) and Ponte Vedra (about $895K) buy coastal or country-club lifestyle at premium prices, hurricane and parking trade-offs, and often high HOA/CDD; Westside (about $285K) and Springfield/Northside (about $245K) are the cheapest and highly variable block by block.

Sources

As of Sep 11, 2026Source 1: movewithmomentum.com Source 2: zillow.com Source 3: reddit.com Source 4: youtube.com

Getting aroundJacksonville’s land area makes commute the make-or-break variable: a 12-mile drive can be 20 minutes off-peak and 50 minutes at 8 a.m., and locals warn that one St. Johns River bridge can wreck a morning. J. Turner Butler Boulevard (JTB) is the main east–west spine toward Southside jobs, St. Johns Town Center, and the beaches; weekday river-bridge backups from about 4–6 p.m. are especially bad beach-bound. Neighborhood fit depends on the hospital—Mayo Clinic versus NAS Jacksonville versus Baptist Health’s large campus network are different maps—and Nocatee is workable for JTB, Town Center, and beaches but needs planning for downtown rush hour. Public transit is limited, a car is essential, and parking is a known hassle in Riverside, Avondale, and Jacksonville Beach; drive the real route at the real shift time before signing a lease.

Jacksonville’s land area makes commute the make-or-break variable: a 12-mile drive can be 20 minutes off-peak and 50 minutes at 8 a.m., and locals warn that one St. Johns River bridge can wreck a morning. J. Turner Butler Boulevard (JTB) is the main east–west spine toward Southside jobs, St. Johns Town Center, and the beaches; weekday river-bridge backups from about 4–6 p.m. are especially bad beach-bound.

Neighborhood fit depends on the hospital—Mayo Clinic versus NAS Jacksonville versus Baptist Health’s large campus network are different maps—and Nocatee is workable for JTB, Town Center, and beaches but needs planning for downtown rush hour. Public transit is limited, a car is essential, and parking is a known hassle in Riverside, Avondale, and Jacksonville Beach; drive the real route at the real shift time before signing a lease.

Sources

As of Sep 11, 2026Source 1: movewithmomentum.com Source 2: youtube.com Source 3: flybreeze.com Source 4: youtube.com Source 5: exprealty.com

OutdoorsLife outdoors runs on 22 miles of Atlantic beach (Jacksonville Beach, Neptune Beach, Atlantic Beach—Jax Beach is the walkable, concert-and-surf hub), the north-flowing St. Johns River, and the salt marshes between them for kayaking, fishing, and paddling. Inland, the 136-acre Jacksonville Arboretum and Botanical Gardens, 46,000-acre Timucuan Ecological and Historic Preserve, Tree Hill Nature Center, and Jacksonville Zoo and Botanical Gardens are the named weekend defaults. About 45 minutes northeast, Big and Little Talbot Island State Parks offer the region’s standout hiking; Kathryn Abbey Hanna Park near Mayport is described as Florida’s largest urban park, alongside Huguenot Memorial Park, Fort Caroline National Memorial, and Julington Durbin Creek Nature Preserve. The city claims the largest urban park system in the country across roughly 840 square miles.

Life outdoors runs on 22 miles of Atlantic beach (Jacksonville Beach, Neptune Beach, Atlantic Beach—Jax Beach is the walkable, concert-and-surf hub), the north-flowing St. Johns River, and the salt marshes between them for kayaking, fishing, and paddling. Inland, the 136-acre Jacksonville Arboretum and Botanical Gardens, 46,000-acre Timucuan Ecological and Historic Preserve, Tree Hill Nature Center, and Jacksonville Zoo and Botanical Gardens are the named weekend defaults.

About 45 minutes northeast, Big and Little Talbot Island State Parks offer the region’s standout hiking; Kathryn Abbey Hanna Park near Mayport is described as Florida’s largest urban park, alongside Huguenot Memorial Park, Fort Caroline National Memorial, and Julington Durbin Creek Nature Preserve. The city claims the largest urban park system in the country across roughly 840 square miles.

Sources

As of Sep 11, 2026Source 1: zillow.com Source 2: visitflorida.com Source 3: visitjacksonville.com Source 4: flybreeze.com Source 5: thehonestlocal.com

Others hiring in Jacksonville, FL

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Moving costs

Relocation assistance offered

This posting

Living in Jacksonville

Jacksonville is the largest city by land area in the contiguous U.S., which means Riverside’s oak-lined bungalows, Mandarin’s big lots, and Jacksonville Beach’s surf towns share a name but not a daily rhythm. That sprawl is the draw: 22 miles of public beach, the north-flowing St. Johns River, Timucuan Preserve, and a housing market still listing around the high $200Ks citywide—far below Miami or Tampa—plus about 225 mostly sunny days. It is also the trap. A 12-mile hop can be 20 minutes or 50 at 8 a.m.; river bridges clog 4–6 p.m., and Google Maps routinely understates the trip to Mayo Clinic, NAS Jacksonville, or Baptist campuses. Young professionals gravitate to Riverside, Avondale, San Marco, and cheaper Murray Hill for King Street brunch, Five Points bars, and the Saturday Riverside Arts Market; families often pay up for Nocatee’s splash pads and St. Johns County schools or stay in Mandarin and Orange Park. Bring a car, check flood zones and CDD fees, and drive your real commute before you sign.

AI area guide

Sources

As of 2026Source 1: movewithmomentum.com Source 2: zillow.com Source 3: youtube.com Source 4: flybreeze.com Source 5: thehonestlocal.com Source 6: youtube.com

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Do you qualify?

Preferred

What it pays

Benefits

The role and schedule

The workplace

The team behind this role

Ask Mira

Your fit

Questions to ask

On your path

Original listing

Why Mayo Clinic

Benefits Highlights

Responsibilities

Join a Life-Changing Career Path at Mayo Clinic

This isn’t just a career search — it’s your chance to

What to Expect After Applying

Qualifications

Certification

Exemption Status

Compensation Detail

Benefits Eligible

Schedule

Hours/Pay Period

Schedule Details

Weekend Schedule

International Assignment

Site Description

Equal Opportunity

Recruiter

Pension & 403(b)/401(k) Match

Continuing Medical Education

Paid Time Off & Disability

Relocation Assistance

Choose From a Wide Number of Specialties and Settings

What's around it?

Jacksonville, FLiFrom Census ACS 2024.

Life in Jacksonville, FL

Moving for this role?

Nurses on this role

Nurses on this role

The team behind this role

Life in Jacksonville, FL

Moving for this role?

Nurses on this role

Jacksonville, FLFrom Census ACS 2024.