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33 nursing jobs in Mission, TX

Positioned along the Rio Grande with living costs about 14% below the national average, Mission delivers a welcoming bicultural pace. Hospital commutes average 18 to 19 minutes along Expressway 83 with ample surface parking. Off shift, grab Delia’s tamales, explore Bentsen-Rio Grande Valley State Park, or settle into quiet neighborhoods zoned to Sharyland.

Mission, TX on the map· Open the live map
Mission Regional Medical Center workplace
Mission Regional Medical Center — a workplace named in a current Mission postingView Mission Regional Medical Center →

Find a nursing job in Mission

Hiring here: Mission Regional Medical Center (23) · Prime Healthcare (3) · Mission Regional Medical Center (2) · Angels of Care Pediatric Home Health (1) · Mission Doctor's Group (1) · Mission Nursing & Rehabilitation (1)

Mission Regional Medical Center workplace

Mission Regional Medical Center

20 open roles

Registered Nurse- Med/Surg

Mission, TX · Posted 4 days ago

  • Sign-on bonus
  • RN
  • Night shift

Registered Nurse-Nursery

Mission, TX · Posted 4 days ago

  • Sign-on bonus
  • RN
  • Day shift

Registered Nurse- Recovery Room

Mission, TX · Posted 6 days ago

  • RN
  • Day shift

Registered Nurse- Recovery Room

Mission, TX · Posted 6 days ago

  • RN
  • Day shift

Registered Nurse- Med/Surg Acute Unit

Mission, TX · Posted last week

  • RN
  • Day shift

Registered Nurse-Telemetry Unit

Mission, TX · Posted last week

  • Sign-on bonus
  • RN
  • Day shift

Registered Nurse- Renal Dialysis

Mission, TX · Posted last week

  • RN
  • Rotating shift
  • Per diem

Registered Nurse-Telemetry Unit

Mission, TX · Posted last week

  • Sign-on bonus
  • RN
  • Night shift

Registered Nurse-Definitive Observation Unit

Mission, TX · Posted last week

  • Sign-on bonus
  • RN
  • Night shift

Registered Nurse- Telemetry Unit 1

Mission, TX · Posted last week

  • Sign-on bonus
  • RN
  • Night shift

Registered Nurse-Telemetry Unit

Mission, TX · Posted last week

  • Sign-on bonus
  • RN
  • Night shift

Registered Nurse- Telemetry Unit

Mission, TX · Posted last week

  • Sign-on bonus
  • RN
  • Night shift

Registered Nurse-Definitive Observation Unit

Mission, TX · Posted last week

  • RN
  • Night shift

Nursing Assistant - Telemetry Unit

Mission, TX · Posted last week

  • CNA
  • Day shift

Registered Nurse- Surgery

Mission, TX · Posted last week

  • Sign-on bonus
  • RN
  • Day shift

Cardiac Catheterization Laboratory RN

Mission, TX · Posted last week

  • RN
  • Per diem

Registered Nurse- Definitive Observation Unit

Mission, TX · Posted last week

  • Sign-on bonus
  • RN
  • Night shift

Registered Nurse-Emergency Services

Mission, TX · Posted last week

  • Sign-on bonus
  • RN
  • Day shift

Registered Nurse-Telemetry Unit

Mission, TX · Posted last week

  • Sign-on bonus
  • RN
  • Day shift

LVN- Wound Care

Mission, TX · Posted last week

  • LVN
  • Per diem

Mission Nursing & Rehabilitation

Mission, TX

  • RN
  • Per diem
  • Tuition reimbursement

Mission Doctor's Group

Mission, TX

  • NP
  • Day shift

Mission Valley Nursing and Transitional Care

Mission, TX

Certified Nurse Aide

Posted last week

  • CNA
  • Day shift

Mission Regional Medical Center

Mission, TX

  • RN
  • Night shift
  • Per diem
Prime Healthcare Services logo

Prime Healthcare Services

Mission, TX

  • LVN
  • Night shift
  • Per diem

Angels of Care Pediatric Home Health

Mission, TX

  • New grads welcomed
  • RN/LPN/LVN
  • Ratio 1:1
  • Day shift
Prime Healthcare logo

Prime Healthcare

Mission, TX · Health system employer

  • Sign-on bonus
  • RN
  • Day shift

Mission Regional Medical Center

Mission, TX

  • New grads welcomed
  • RN
  • Day shift
Prime Healthcare logo

Prime Healthcare

Mission, TX · Health system employer

  • RN
Mission Regional Medical Center logo

Mission Regional Medical Center

Mission, TX

  • Sign-on bonus
  • RN
  • 12-⁠hour nights
Prime Healthcare logo

Prime Healthcare

Mission, TX · Health system employer

  • RN
  • Variable
  • Hemodialysis Unit
Mission Regional Medical Center logo

Mission Regional Medical Center

Mission, TX

  • RN
  • Day shift
  • Tuition reimbursement
Mission Regional Medical Center logo

Mission Regional Medical Center

Mission, TX

  • RN
  • Day shift
  • Per diem

Working and living in Mission

· 33 open roles

Living costs

Metro price level
85.9 (100 = national)
BEA 2024
Median gross rent
$950/mo
Rent and tenant-paid utilities
Median household income
$60,767/yr
All local households, not nurse pay

Census ACS 2024

Open to new grads

2 postings explicitly welcome new grads.

Browse new grad roles

New to our board this week

5 current postings first appeared here in the past seven days.

Browse current openings

Credentials accepted

  • NP1
  • RN28
  • LPN1
  • LVN3
  • CNA2

One posting may accept more than one credential.

Shifts listed

  • Days16
  • Nights11
  • per-diem3
  • Rotating2

Postings may list several shifts or leave the shift unspecified.

Living in Mission

Mission offers relocating nurses a welcoming foothold in the lower Rio Grande Valley, situated directly along the Rio Grande and immediately west of McAllen.

More about life here

Known as the 'Home of the Ruby Red Grapefruit,' the community is distinguished by its vibrant bicultural heritage, cross-border ties via the Anzalduas International Bridge, and world-class ecotourism hubs like Bentsen-Rio Grande Valley State Park and the National Butterfly Center. Healthcare workers benefit from short, low-stress vehicle commutes along Expressway 83, connecting directly to major hospitals across Hidalgo County.

Housing options range from modern gated subdivisions like Lantana Landing to sought-after family enclaves zoned to Sharyland ISD. Dining centers on authentic border cuisine, from tamales at Delia's to waterfront meals at the Riverside Club on the River.

Relocating nurses should anticipate hot, humid summers exceeding 100 degrees and a total reliance on personal vehicles, as public transit is sparse. For medical professionals seeking an unhurried lifestyle, strong community ties, and rich cultural flavor, Mission delivers an appealing, accessible home base.

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As of Sep 16, 2026
Neighborhoods

Residential options in Mission range from established corridors near downtown to expanding developments along North Shary Road and Conway Avenue. Newer gated communities like Lantana Landing on Trosper Road and Laguna Oaks Phase 2 near Expressway 83 attract professionals wanting modern construction and controlled access.

Families and relocating staff frequently concentrate in subdivisions associated with Sharyland ISD, including John H Shary, West Addition to Sharyland, Marbella Phase II Sharyland Plantation Village, and Glasscock Hills. Other established residential pockets include West Sharyland, Mission Manor, and Aladdin Villas, which offer mature trees, larger lots, and straightforward surface-street navigation.

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Housing

Mission's housing stock predominantly consists of single-family detached homes, low-density apartment communities, and a growing inventory of townhomes in outer subdivisions. Newer gated communities such as Lantana Landing provide modern layouts and private amenities, while golf course and master-planned neighborhoods near Sharyland feature spacious lots.

Downtown and central corridors retain modest, established ranch-style homes. Renters desiring urban-style lofts or mid-rise apartment buildings generally commute from adjacent McAllen.

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Getting around

Driving is the standard commute method across Mission, with local trips typically averaging around 18 to 19 minutes. Expressway 83 serves as the primary east-west spine connecting Mission directly into McAllen's healthcare facilities and commercial centers, while Conway Avenue and North Shary Road handle local north-south traffic.

Public transportation is very limited and personal vehicles are essential for shift workers. Hospital parking across the Rio Grande Valley is generally ample and surface-lot based, avoiding the high garage fees and congestion typical of major Texas metropolitan centers.

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Food and dining

Mission's culinary landscape features authentic regional Mexican cooking, hearty Tex-Mex, and traditional South Texas diners. Local staples include tamales at Delia's and morning comfort food at The Griffin Grill and Diaz Diner Restaurant.

Quick-casual and budget favorites include Taco Palenque, Pho Le Lai, Rosie's, and Ranch House. For evening outings or scenic meals, residents gather on the water at Riverside Club on the River or enjoy upscale Mexican dishes and music at La Fogata Restaurant & Piano Bar.

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Outdoors

Mission is an internationally recognized hub for birding and wildlife observation along the Rio Grande corridor. Bentsen-Rio Grande Valley State Park serves as headquarters for the World Birding Center network, featuring miles of hiking and biking trails, observation towers, and tram tours through protected subtropical woodlands.

Nearby, the National Butterfly Center supports over 100 butterfly species and native gardens. For sports and local recreation, the city maintains the Mission Mountain Bike Park alongside golf venues including Shary Municipal Golf Course, Meadow Creek Resort, and Martin Valley Ranch.

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Arts and culture

Known as the 'Home of the Ruby Red Grapefruit,' Mission celebrates its agricultural roots with the long-running Texas Citrus Fiesta, established in 1932 and featuring parades, pageants, and live music. In November, naturalists gather for the Rio Grande Valley Birding Festival.

Cultural history is preserved at the historic 1865 La Lomita Chapel on the river, the Mission Historical Museum, and the Xochil Art and Culture Center. For motorsport entertainment, Mission Raceway Park hosts go-kart and dragstrip racing.

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Seasons and weather

Mission experiences a semi-arid, subtropical climate characterized by long, intensely hot summers and very mild winters. Summer daytime highs routinely surpass 100 degrees Fahrenheit with heavy humidity that requires indoor air conditioning and shift-work hydration planning.

Winters are gentle, sunny, and freeze-free with zero annual snowfall, creating an inviting late-autumn through early-spring window for birdwatching, trail cycling, and outdoor citrus harvest festivals.

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For families

The city offers an established family-friendly environment with strong community support and extensive youth recreation programs. School zoning is a major priority for relocating families, with neighborhoods feeding into Sharyland Independent School District commanding high interest.

Subdivisions like Glasscock Hills, Marbella Phase II, and John H Shary offer quiet, low-traffic residential streets close to city parks, nature preserves, and community sporting facilities.

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What locals say

Residents describe Mission as a warm, family-oriented border community steeped in South Texas and Mexican culture, where bilingual Spanish-English communication is commonplace and deeply advantageous. Locals value the relaxed lifestyle, welcoming neighborhoods, and easy access to outdoor ecotourism along the Rio Grande.

The primary frustrations cited are the grueling summer heat, the lack of extensive public transit, and a relatively quiet nightlife scene that forces younger residents to travel to neighboring McAllen for upscale entertainment and diverse nightlife.

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