Prisma Health
Academic Medical Center · Columbia, SC
- 145
- open roles, live count
- 2.4
- Google rating
Life here
What a shift at Prisma Health looks like
On the floor
What the day-to-day looks like
- Setting
- Academic Medical Center
- Shifts hiring now
- Days 24 · Nights 14 · Evenings 1 · Rotating 1
Benefits
Prisma Health states it offers a variety of health and wellness benefits designed to cover all aspects of employees' lives.
Who they are
Prisma Health is a large South Carolina-based healthcare system with nearly 32,000 team members, serving communities across the state including its Columbia market.
- Academic Medical Center · Columbia, SC
- Hiring days & nights & evenings
More about Prisma Health
The organization describes itself as being on a journey to transform the healthcare experience for patients and families, with goals centered on enhancing clinical quality, patient experience, and access to affordable care. Prisma Health also engages in clinical research and trains the next generation of healthcare providers, suggesting an academic or teaching mission. Nursing roles at Prisma Health span a variety of settings, from hospice and palliative care to remote post-discharge outreach positions, indicating a range of practice environments for nurses. The system emphasizes regulatory compliance with bodies such as The Joint Commission and DHEC, and operates under the scope of the SC Nursing Practice Act. Remote nursing opportunities are available for South Carolina residents, particularly in care coordination and patient follow-up roles. The organization places strong emphasis on diversity, teamwork, and a culture of compassionate service across all care settings.
Prisma Health's stated purpose is: 'Inspire health. Serve with compassion. Be the difference.' The organization is committed to creating a culture that inspires and motivates team members to excel for the benefit of all those served. Core values include caring for everyone regardless of background, beliefs, or appearance; fostering diversity and inclusion; and working collaboratively as a team. The organization believes that different voices, lived experiences, and backgrounds nurture its workplace culture and lead to better communication, decisions, and outcomes.
Working here
Culture and working life
What to consider
The good
- Large health system with approximately 32,000 team members, offering diverse nursing career paths and settings
- Remote nursing positions available for South Carolina residents, including post-discharge outreach roles
- Strong stated commitment to diversity, inclusion, and valuing different backgrounds and lived experiences
- Culture emphasized as collaborative and team-oriented across emergency care, maternity, and other service lines
- Engagement in clinical research and training of future healthcare providers, offering potential professional growth opportunities
- Mission-driven organization with clear purpose focused on community health improvement
The hard parts
- Extensive compliance and policy requirements may create administrative burden for nursing staff
- Large organizational size of nearly 32,000 employees may lead to bureaucratic challenges or feeling disconnected from leadership
The reality check
Before you decide
Quick facts
- Relationship
- Direct employer
- Roles last seen active
- Sep 10, 2026
- Workplace photos
- 1
- Website
- prismahealth.org ↗
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Work here?
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Units hiring now
Open counts come from the live roles below. Grouped as the postings state them.
Open roles
Current openings at Prisma Health
Refreshed throughout the day.
Registered Nurse (RN) - Lactation Consultant, PRN, Day
Greenville, SC · Posted yesterday
- RN
- Per diem
Registered Nurse (RN) - Acute Care, Medical/Surgical, FT, Nights
Maryville, TN · Posted yesterday
- RN
Registered Nurse (RN) - Acute Care, Medical/Surgical Nursing, FT, Nights
Maryville, TN · Posted yesterday
- RN
Registered Nurse (RN) Acute Care, Emergency Trauma Center, PRN, Variable
Simpsonville, SC · Posted yesterday
- RN
- Per diem
Registered Nurse (RN)-Employer Health Services, FT, Day
Columbia, SC · Posted 2 days ago
- RN
Registered Nurse (RN)-Outpatient, Radiology Nursing Services, PRN, Days
Greenville, SC · Posted 2 days ago
- RN
- Per diem
Registered Nurse (RN) - Nurse Resident, December 2026, ICU Medical
Maryville, TN · Posted 2 days ago
- New grads welcomed
- RN
- Residency program
Registered Nurse (RN) - Lactation Consultant, Women's Education, PT, Days
Greenville, SC · Posted 2 days ago
- RN
Registered Nurse (RN)-Acute Care, Facility Resource Pool, Medical/Surgical/Telemetry, FT, Night
Greenville, SC · Posted 6 days ago
- RN
- Night shift
- Compact license OK
Registered Nurse (RN)-Acute Care, Cardiovascular ICU (CVICU), PRN, Night
Greenville, SC · Posted 6 days ago
- RN
- Night shift
- Per diem
Registered Nurse (RN)-Acute Care, Cardiovascular ICU (CVICU), PT, Night
Greenville, SC · Posted 6 days ago
- RN
- Night shift
- Compact license OK
Registered Nurse (RN)-Acute Care, The Family Birthplace, PRN, Nights
Maryville, TN · Posted last week
- RN
- Night shift
- Per diem
Registered Nurse (RN) - Acute Care, Transplant and Intermediate Care, PRN, Day
Greenville, SC · Posted last week
- RN
- Day shift
- Per diem
Registered Nurse (RN) - Transplant Coordinator, Liver Transplant Program, FT, Days
Greenville, SC · Posted last week
- New grads welcomed
- RN
- Day shift
- Transplant Service - Liver
Registered Nurse (RN)-Acute Care, OR Pre-Op, PT, Day
Greenville, SC · Posted last week
- RN
- Day shift
- Compact license OK
Registered Nurse (RN)-Hospice Outpatient, Hospice, FT, Days
Maryville, TN · Posted last week
- RN
- Day shift
- Compact license OK
Registered Nurse (RN) - Acute Care, Neonatal Intensive Care Unit, NICU, FT, Nights
Columbia, SC · Posted last week
- RN
- Night shift
- Compact license OK
Admissions Coordinator, Day Treatment, FT, Day
Greenville, SC · Posted last week
- RN
- Day shift
- Compact license OK
Registered Nurse (RN)- Ambulatory, Pediatrics & Internal Medicine, FT, Day
Duncan, SC · Posted last week
- New grads welcomed
- RN
- Day shift
- Compact license OK
Registered Nurse (RN) - Acute Care, Richland Facility Resource Pool, PT, Days
Columbia, SC · Posted last week
- RN
- Day shift
- ADN accepted
Registered Nurse (RN)- Nurse Resident, December 2026, Emergency Department
Columbia, SC · Posted last week
- New grads welcomed
- RN
- Rotating shift
- Compact license OK
Registered Nurse (RN)- Ambulatory, Surgical, FT, Day
Columbia, SC · Posted last week
- New grads welcomed
- RN
- Day shift
- Compact license OK
Registered Nurse (RN) - Ambulatory Care, Pediatric Cardiology, FT
Greenville, SC · Posted last week
- New grads welcomed
- RN
- Day shift
- Compact license OK
Registered Nurse (RN) - Acute Care, Med Surg - Geriatrics, Oncology, PT, Nights
Columbia, SC · Posted last week
- RN
- Day shift
- Compact license OK
Registered Nurse (RN) - Acute, Rehabilitation, FT, Nights
Greenville, SC · Posted 2 weeks ago
- RN
- Night shift
- Compact license OK
Registered Nurse, Emergency Department, Full-Time, Evening
Maryville, TN · Posted 2 weeks ago
- RN
- Evening shift
- Compact license OK
Registered Nurse (RN)-Acute Care, Emergency Department, Full Time, Days
Sumter, SC · Posted 2 weeks ago
- RN
- Day shift
- Compact license OK
Registered Nurse (RN)-Nurse Informaticist, Full-Time, Days
Sumter, SC · Posted 2 weeks ago
- RN
- Day shift
Registered Nurse (RN) - Acute Care, Facility Resource Pool, FT, Days
Columbia, SC · Posted 2 weeks ago
- RN
- Day shift
- Compact license OK
Registered Nurse (RN) - Acute Care, Facility Resource Pool, Richland, FT, Days
Columbia, SC · Posted 2 weeks ago
- RN
- Day shift
- ADN accepted
Registered Nurse (RN) - Acute Care, Nephrology, FT, Nights
Columbia, SC · Posted 2 weeks ago
- RN
- Night shift
- ADN accepted
Licensed Practical Nurse (LPN) - Ambulatory Care, Minimally Invasive Surgery and Weight Management Institute, FT
Greenville, SC · Posted 2 weeks ago
- New grads welcomed
- LPN
- Day shift
- Compact license OK
Registered Nurse (RN) - Acute Care, Neonatal Intermediate, FT, Nights
Greenville, SC
- RN
- Night shift
- Compact license OK
Assistant Nurse Manager, Behavioral Health, FT, Nights
Greenville, SC
- RN
- Night shift
- Compact license OK
Registered Nurse (RN) - Acute Care, Family Beginnings (Postpartum), FT, Nights
Greenville, SC
- RN
- Night shift
- Compact license OK
Registered Nurse (RN) Outpatient Oncology, Ambulatory Infusion Center (ICARE), PRN, Days
Greer, SC
- RN
- Day shift
- Per diem
Registered Nurse (RN) Acute Care, Labor and Delivery, FT, Nights
Greer, SC
- RN
- Night shift
- Compact license OK
Registered Nurse (RN) - Ambulatory Care, Gastroenterology, FT
Simpsonville, SC
- New grads welcomed
- RN
- Day shift
- Compact license OK
Registered Nurse (RN) - Acute Care, Pulmonary Medicine, FT, Night
Greenville, SC
- RN
- Night shift
- Compact license OK
Registered Nurse (RN) - Employee Health, Full-Time, Days
Greenville, SC · Seen active last week
- RN
- Day shift
- Compact license OK
Registered Nurse (RN)-Acute Care, Family Beginnings, FT, Night
Greenville, SC
- RN
- Night shift
- Compact license OK
Registered Nurse (RN)-Hospice Inpatient, [Blount] Full Time, Day
Maryville, TN
- New grads welcomed
- RN
- Day shift
- Compact license OK
Registered Nurse (RN) Acute Care, Orthopedics, FT Nights
Columbia, SC
- RN
- Night shift
- Compact license OK
Registered Nurse (RN) - Clinical Educator I, Critical Care, Full-Time, Days
Greenville, SC
- RN
- Day shift
- Compact license OK
Registered Nurse (RN) Acute Care, Orthopedics, FT Days
Columbia, SC
- RN
- Day shift
- Compact license OK
Registered Nurse (RN) - Clinical Nurse Educator I, Pediatrics, Full-Time, Days
Columbia, SC
- RN
- Day shift
- Per diem
Registered Nurse (RN)-Home Infusion Clinical Liaison, PRN, Days
Greenville, SC
- RN
- Day shift
- Per diem
Showing 48 of 145.
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