Skip to content
Nursing Mastery
Prisma Health workplace
Prisma Health logo

Prisma Health

Academic Medical Center · Columbia, SC

See 145 open roles

Loading full-size photo…

Prisma Health workplace
145
open roles, live count
2.4
Google rating

Life here

What a shift at Prisma Health looks like

Loading full-size photo…

Prisma Health workplace

On the floor

What the day-to-day looks like

Setting
Academic Medical Center
Shifts hiring now
Days 24 · Nights 14 · Evenings 1 · Rotating 1

Benefits

Prisma Health states it offers a variety of health and wellness benefits designed to cover all aspects of employees' lives.

Who they are

Prisma Health is a large South Carolina-based healthcare system with nearly 32,000 team members, serving communities across the state including its Columbia market.

  • Academic Medical Center · Columbia, SC
  • Hiring days & nights & evenings
More about Prisma Health

The organization describes itself as being on a journey to transform the healthcare experience for patients and families, with goals centered on enhancing clinical quality, patient experience, and access to affordable care. Prisma Health also engages in clinical research and trains the next generation of healthcare providers, suggesting an academic or teaching mission. Nursing roles at Prisma Health span a variety of settings, from hospice and palliative care to remote post-discharge outreach positions, indicating a range of practice environments for nurses. The system emphasizes regulatory compliance with bodies such as The Joint Commission and DHEC, and operates under the scope of the SC Nursing Practice Act. Remote nursing opportunities are available for South Carolina residents, particularly in care coordination and patient follow-up roles. The organization places strong emphasis on diversity, teamwork, and a culture of compassionate service across all care settings.

Prisma Health's stated purpose is: 'Inspire health. Serve with compassion. Be the difference.' The organization is committed to creating a culture that inspires and motivates team members to excel for the benefit of all those served. Core values include caring for everyone regardless of background, beliefs, or appearance; fostering diversity and inclusion; and working collaboratively as a team. The organization believes that different voices, lived experiences, and backgrounds nurture its workplace culture and lead to better communication, decisions, and outcomes.

Working here

Culture and working life

compassionateteam-orienteddiverseinclusivemission-driventransformativecollaborativecompliance-focused

What to consider

The good

  • Large health system with approximately 32,000 team members, offering diverse nursing career paths and settings
  • Remote nursing positions available for South Carolina residents, including post-discharge outreach roles
  • Strong stated commitment to diversity, inclusion, and valuing different backgrounds and lived experiences
  • Culture emphasized as collaborative and team-oriented across emergency care, maternity, and other service lines
  • Engagement in clinical research and training of future healthcare providers, offering potential professional growth opportunities
  • Mission-driven organization with clear purpose focused on community health improvement

The hard parts

  • Extensive compliance and policy requirements may create administrative burden for nursing staff
  • Large organizational size of nearly 32,000 employees may lead to bureaucratic challenges or feeling disconnected from leadership

The reality check

Before you decide

Quick facts

Relationship
Direct employer
Roles last seen active
Sep 10, 2026
Workplace photos
1
Ask Mira about Prisma Health

Weighing a first job here?

The license clock and the job hunt run at once, and new-grad windows do the deciding. Residency commitments carry fine print worth reading before you sign.

Work here?

This page is built from public postings and employer research. Help us get it right: corrections, photos, and the story of the floor itself.

Improve this page →

Open roles

Current openings at Prisma Health

Refreshed throughout the day.

Registered Nurse (RN) - Lactation Consultant, PRN, Day

Prisma Health logoPrisma Health

Greenville, SC · Posted yesterday

  • RN
  • Per diem
Apply

Registered Nurse (RN) - Acute Care, Medical/Surgical, FT, Nights

Prisma Health logoPrisma Health

Maryville, TN · Posted yesterday

  • RN
Apply
  • RN
Apply

Registered Nurse (RN) Acute Care, Emergency Trauma Center, PRN, Variable

Prisma Health logoPrisma Health

Simpsonville, SC · Posted yesterday

  • RN
  • Per diem
Apply

Registered Nurse (RN)-Employer Health Services, FT, Day

Prisma Health logoPrisma Health

Columbia, SC · Posted 2 days ago

  • RN
Apply

Registered Nurse (RN)-Outpatient, Radiology Nursing Services, PRN, Days

Prisma Health logoPrisma Health

Greenville, SC · Posted 2 days ago

  • RN
  • Per diem
Apply

Registered Nurse (RN) - Nurse Resident, December 2026, ICU Medical

Prisma Health logoPrisma Health

Maryville, TN · Posted 2 days ago

  • New grads welcomed
  • RN
  • Residency program
Apply
  • RN
Apply
  • RN
  • Night shift
  • Compact license OK
Apply

Registered Nurse (RN)-Acute Care, Cardiovascular ICU (CVICU), PRN, Night

Prisma Health logoPrisma Health

Greenville, SC · Posted 6 days ago

  • RN
  • Night shift
  • Per diem
Apply

Registered Nurse (RN)-Acute Care, Cardiovascular ICU (CVICU), PT, Night

Prisma Health logoPrisma Health

Greenville, SC · Posted 6 days ago

  • RN
  • Night shift
  • Compact license OK
Apply

Registered Nurse (RN)-Acute Care, The Family Birthplace, PRN, Nights

Prisma Health logoPrisma Health

Maryville, TN · Posted last week

  • RN
  • Night shift
  • Per diem
Apply
  • RN
  • Day shift
  • Per diem
Apply
  • New grads welcomed
  • RN
  • Day shift
  • Transplant Service - Liver
Apply

Registered Nurse (RN)-Acute Care, OR Pre-Op, PT, Day

Prisma Health logoPrisma Health

Greenville, SC · Posted last week

  • RN
  • Day shift
  • Compact license OK
Apply

Registered Nurse (RN)-Hospice Outpatient, Hospice, FT, Days

Prisma Health logoPrisma Health

Maryville, TN · Posted last week

  • RN
  • Day shift
  • Compact license OK
Apply
  • RN
  • Night shift
  • Compact license OK
Apply

Admissions Coordinator, Day Treatment, FT, Day

Prisma Health logoPrisma Health

Greenville, SC · Posted last week

  • RN
  • Day shift
  • Compact license OK
Apply
  • New grads welcomed
  • RN
  • Day shift
  • Compact license OK
Apply
  • RN
  • Day shift
  • ADN accepted
Apply
  • New grads welcomed
  • RN
  • Rotating shift
  • Compact license OK
Apply

Registered Nurse (RN)- Ambulatory, Surgical, FT, Day

Prisma Health logoPrisma Health

Columbia, SC · Posted last week

  • New grads welcomed
  • RN
  • Day shift
  • Compact license OK
Apply

Registered Nurse (RN) - Ambulatory Care, Pediatric Cardiology, FT

Prisma Health logoPrisma Health

Greenville, SC · Posted last week

  • New grads welcomed
  • RN
  • Day shift
  • Compact license OK
Apply
  • RN
  • Day shift
  • Compact license OK
Apply

Registered Nurse (RN) - Acute, Rehabilitation, FT, Nights

Prisma Health logoPrisma Health

Greenville, SC · Posted 2 weeks ago

  • RN
  • Night shift
  • Compact license OK
Apply

Registered Nurse, Emergency Department, Full-Time, Evening

Prisma Health logoPrisma Health

Maryville, TN · Posted 2 weeks ago

  • RN
  • Evening shift
  • Compact license OK
Apply
  • RN
  • Day shift
  • Compact license OK
Apply

Registered Nurse (RN)-Nurse Informaticist, Full-Time, Days

Prisma Health logoPrisma Health

Sumter, SC · Posted 2 weeks ago

  • RN
  • Day shift
Apply

Registered Nurse (RN) - Acute Care, Facility Resource Pool, FT, Days

Prisma Health logoPrisma Health

Columbia, SC · Posted 2 weeks ago

  • RN
  • Day shift
  • Compact license OK
Apply
  • RN
  • Day shift
  • ADN accepted
Apply

Registered Nurse (RN) - Acute Care, Nephrology, FT, Nights

Prisma Health logoPrisma Health

Columbia, SC · Posted 2 weeks ago

  • RN
  • Night shift
  • ADN accepted
Apply
  • New grads welcomed
  • LPN
  • Day shift
  • Compact license OK
Apply
  • RN
  • Night shift
  • Compact license OK
Apply
  • RN
  • Night shift
  • Compact license OK
Apply
  • RN
  • Night shift
  • Compact license OK
Apply
  • RN
  • Night shift
  • Compact license OK
Apply
  • New grads welcomed
  • RN
  • Day shift
  • Compact license OK
Apply
  • RN
  • Night shift
  • Compact license OK
Apply

Registered Nurse (RN) - Employee Health, Full-Time, Days

Prisma Health logoPrisma Health

Greenville, SC · Seen active last week

  • RN
  • Day shift
  • Compact license OK
Apply
  • RN
  • Night shift
  • Compact license OK
Apply
  • New grads welcomed
  • RN
  • Day shift
  • Compact license OK
Apply
  • RN
  • Night shift
  • Compact license OK
Apply
  • RN
  • Day shift
  • Compact license OK
Apply
  • RN
  • Day shift
  • Compact license OK
Apply
  • RN
  • Day shift
  • Per diem
Apply
  • RN
  • Day shift
  • Per diem
Apply
  • RN
  • Day shift
  • Per diem
Apply
Help improve this pageShare what it’s like, fix a detail, or add a useful photo.
What would you like to do?
Add ratings or a short headline

A person reviews every submission before anything changes.