39 nursing jobs in Santa Ana, CA
Santa Ana is the county seat of Orange County, known for its lively downtown arts district, diverse culinary scene, and warm Southern California climate. Nurses relocating here enjoy proximity to major healthcare systems and easy access to nearby beaches.
Find a nursing job in Santa Ana
Hiring here: Kindred Hospital Santa Ana (7) · KPC GLOBAL MEDICAL CENTERS INC. (6) · Wellpath (5) · a45074b6-b45e-424e-9e71-c45a4d73c34b (4) · Kindred Hospitals (3) · AltaMed Health Services Corporation (2)
Registered Nurse Outpatient Oncology
$45–$57/hr
- RN
- Day shift
- Tuition reimbursement
- RN
- FT Nights
- Compact license OK
Registered Nurse (Golden Years) - Full Time 12hr Nights
Santa Ana, CA
$49–$73/hr
- RN
- 12-hour nights
- Per diem
Registered Nurse Per Diem Nights
$44–$56/hr
- RN
- Night shift
- Per diem
- RN
- 12-hour nights
- ADN accepted
Registered Nurse I 12hr (Nights)
$43–$65/hr
- RN
- 12-hour nights
- ADN accepted
Case Manager PRN Days
$45,000–$57,000/year
- RN/LPN/LVN
- Day shift
- Per diem
- RN
- Day shift
- Sign-on bonus
- RN
- Nights
- Per diem
Registered Nurse (ER) - Full Time Day Shift 12 Hour
Posted last week
- RN
- 12-hour days
- Per diem
Registered Nurse RN ICU FT Days
$51–$64/hr
- Sign-on bonus
- RN
- Day shift
- Compact license OK
Registered Nurse (ER) - Full Time Day Shift 12 Hour
Posted last week
- RN
- 12-hour days
- Per diem
- CNA
- FT Days
Registered Nurse, Case Manager & Care Coordinator Team Lead
From $104,000/year
- RN
- Day shift
- Tuition reimbursement
Emergency Room Registered Nurse 12hr (PD- Days)
Posted 2 days ago
- RN
- Day shift
- Per diem
Registered Nurse
$38–$48/hr
- RN
- Full-time NOC shift; 7:00 pm to 7:30 am
- +$2/hr differential
- RN
- FT Nights
- Compact license OK
- Sign-on bonus
- RN
- Night shift
- Per diem
Supervisor Clinic LPN LVN - Pediatrics
Posted last week
- LPN/LVN
- CNA
- Day shift
(NICU) Registered Nurse 12 (PT- Nights)
Posted 2 days ago
- RN
- Night shift
- Per diem
(NICU) Registered Nurse 12 (PD - Nights)
Posted 2 days ago
- RN
- Night shift
- Per diem
Registered Nurse II ICU-12hr (FT-Nights)
Posted 2 days ago
- RN
- Night shift
- Per diem
Working and living in Santa Ana
· 39 open roles
Living costs
- Median gross rent
- $2,082/mo
- Rent and tenant-paid utilities
- Median household income
- $93,999/yr
- All local households, not nurse pay
New to our board this week
6 current postings first appeared here in the past seven days.
Credentials accepted
- RN31
- LPN3
- LVN6
- CNA4
One posting may accept more than one credential.
Shifts listed
- Days14
- Nights13
- per-diem3
- Rotating1
Postings may list several shifts or leave the shift unspecified.
Living in Santa Ana
Santa Ana stands out as the historic and cultural heart of Orange County, offering relocating nurses a deeply authentic, energetic urban core distinct from the master-planned suburbs surrounding it.
More about life hereShow less
Healthcare professionals can base themselves in walkable downtown lofts near the Artists Village, historic Spanish Revival homes in Washington Square and Floral Park, or modern mid-rise complexes in South Coast Metro. Centrally located along Interstate 5 and State Route 55, the city provides straightforward access to major healthcare networks across central and coastal Orange County, though peak-hour freeway congestion demands careful schedule planning.
Off-shift hours can be spent exploring the 4th Street Market food hall, dining at Michelin-recognized spots like Lola Gaspar, touring world-class exhibitions at the Bowers Museum, or biking along the Santa Ana River Trail toward Newport and Huntington beaches. While prospective residents must navigate Southern California's high living expenses, urban density, and neighborhood-to-neighborhood variability, Santa Ana delivers unmatched local character, rich cultural traditions, and premier regional connectivity.
Sources
Neighborhoods
Downtown Santa Ana and the adjacent Artists Village cater to those wanting an urban lifestyle, offering converted historic lofts, mid-rise complexes, and walkable access to galleries and night markets. Floral Park and the Washington Square Historic District feature quiet, tree-lined residential streets populated by restored craftsman bungalows and Spanish Revival homes.
Park Santiago provides a scenic, established neighborhood feel near recreational trails, while the South Coast Metro area on the southern border offers modern apartment communities close to major corporate offices and upscale shopping hubs.
Housing
Housing options in Santa Ana are varied, spanning single-family historic craftsman homes and Spanish Revival architecture in northern pockets like Floral Park to live-work lofts and converted boutique residential buildings downtown. Dense, multi-story mid-rise apartment communities and condominiums cluster in the South Coast Metro district near major commercial centers.
Over half the local population rents, giving newcomers a selection of both older courtyard properties and newer managed apartment developments.
Sources
Getting around
Santa Ana sits at the nexus of Orange County's highway grid, centered on Interstate 5 with direct access to State Route 55, State Route 22, and nearby Interstate 405, allowing rapid access to regional healthcare hubs in Anaheim, Orange, and Irvine. Rush-hour congestion along the I-5 and SR-55 corridors is frequent and can significantly extend shift commutes.
Public transit is anchored by the Santa Ana Regional Transportation Center, serving Metrolink passenger trains and regional bus routes, though personal vehicles remain essential for most healthcare workers navigating rotating hospital schedules.
Sources
Food and dining
The culinary scene centers on Fourth Street—locally known as La Cuatro—and the historic downtown core, home to communal gathering spaces like 4th Street Market and McFadden Public Market. Acclaimed local spots range from Michelin-recognized handmade tortillas and tapas at Lola Gaspar to Mexican-Szechuan fusion broth at Kaizen shabu-shabu and casual dining at Super Panga.
The city also features independent third-wave coffee shops, vibrant michelada spots, craft beer taprooms, and swift access to authentic Vietnamese fare in adjacent Little Saigon.
Outdoors
Outdoor activity centers around the Santa Ana River Trail, a paved multi-use pathway popular with distance runners and cyclists that connects inland Orange County down toward Pacific beaches. Santiago Park offers wooded, hilly walking paths, neighborhood sports facilities, and shaded picnic lawns.
In addition, residents benefit from quick driving access to coastal recreation spots including Newport Beach and Huntington Beach for surfing and coastal walks.
Sources
Arts and culture
Santa Ana functions as the cultural capital of Orange County, anchored by the monthly First Saturday Artwalk, more than two hundred historic and contemporary murals, and creative spaces like Crear Studio and Grand Central Art Center. Landmark institutions include the Bowers Museum, the interactive Discovery Cube Orange County, and the historic Heritage Museum of Orange County.
Nightlife and live entertainment center on the historic Yost Theater downtown and the nearby Observatory music venue.
Sources
Seasons and weather
Santa Ana experiences a mild Mediterranean climate characterized by year-round sunshine and low humidity. Summers are warm and dry, with coastal marine layers often providing morning cloud cover before burning off by midday.
Winters remain comfortable with occasional rain showers, while autumn frequently brings warm days tempered by dry regional winds.
Sources
For families
Family-oriented neighborhoods include Park Santiago, Floral Park, and adjacent residential tracts near Tustin, known for mature trees and neighborhood parks. The local education landscape features specialized programs such as Jim Thorpe Fundamental, Arroyo Elementary, and the acclaimed Orange County School of the Arts (OCSA), alongside private institutions like Mater Dei High School.
Family recreation is supported by hands-on STEM programming at Discovery Cube Orange County, local exhibits at the Santa Ana Zoo, and neighborhood sports facilities.
Sources
What locals say
Residents praise Santa Ana for its authentic community spirit, walkable downtown core, and rich Latino cultural heritage, highlighting its dynamic food scene and arts presence as refreshing alternatives to surrounding planned suburbs. On the other hand, locals consistently point to intense freeway traffic on the 5 and 55, pockets of street-level urban friction, and the general affordability pressures typical of Southern California as regular challenges.