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39 nursing jobs in Santa Ana, CA

Santa Ana is the county seat of Orange County, known for its lively downtown arts district, diverse culinary scene, and warm Southern California climate. Nurses relocating here enjoy proximity to major healthcare systems and easy access to nearby beaches.

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The Oncology Institute of Hope and Innovation workplace
The Oncology Institute of Hope and Innovation — a workplace named in a current Santa Ana postingView The Oncology Institute of Hope and Innovation →

Find a nursing job in Santa Ana

Hiring here: Kindred Hospital Santa Ana (7) · KPC GLOBAL MEDICAL CENTERS INC. (6) · Wellpath (5) · a45074b6-b45e-424e-9e71-c45a4d73c34b (4) · Kindred Hospitals (3) · AltaMed Health Services Corporation (2)

The Oncology Institute of Hope and Innovation

Santa Ana, CA

  • RN
  • Day shift
  • Tuition reimbursement
1 / 2

Registered Nurse FT Nights

Kindred Hospital Santa Ana logoKindred Hospital Santa Ana

Santa Ana, CA · Posted last week

$44–$56/hr

  • RN
  • FT Nights
  • Compact license OK
1 / 2

Operating Room Nurse

Acuity Eye Group logoAcuity Eye Group

Santa Ana, CA

  • RN
1 / 4

Registered Nurse (Golden Years) - Full Time 12hr Nights

KPC Global Medical Centers INC. logoKPC Global Medical Centers INC.

Santa Ana, CA

$49–$73/hr

  • RN
  • 12-⁠hour nights
  • Per diem
Kindred Hospital Santa Ana logo

Kindred Hospital Santa Ana

Santa Ana, CA

  • RN
  • Night shift
  • Per diem
KPC Global Medical Centers INC. logo

KPC Global Medical Centers INC.

Santa Ana, CA

  • RN
  • 12-⁠hour nights
  • ADN accepted
Kindred Hospital Santa Ana logo

Kindred Hospital Santa Ana

Santa Ana, CA

Case Manager FT Days

$94,000–$119,000/year

  • RN/LPN/LVN
  • Day shift
KPC Global Medical Centers INC. logo

KPC Global Medical Centers INC.

Santa Ana, CA

  • RN
  • 12-⁠hour nights
  • ADN accepted
Kindred Hospital Santa Ana logo

Kindred Hospital Santa Ana

Santa Ana, CA

Case Manager PRN Days

$45,000–$57,000/year

  • RN/LPN/LVN
  • Day shift
  • Per diem
KPC Global Medical Centers INC. logo

KPC Global Medical Centers INC.

Santa Ana, CA

  • RN
  • Day shift
Kindred Hospital Santa Ana logo

Kindred Hospital Santa Ana

Santa Ana, CA

Registered Nurse RN FT ICU Nights

Posted last week

$51–$64/hr

  • Sign-on bonus
  • RN
  • Nights
  • Per diem
KPC Global Medical Centers INC. logo

KPC Global Medical Centers INC.

Santa Ana, CA

  • RN
  • 12-⁠hour days
  • Per diem
Kindred Hospital Santa Ana logo

Kindred Hospital Santa Ana

Santa Ana, CA

  • Sign-on bonus
  • RN
  • Day shift
  • Compact license OK
KPC Global Medical Centers INC. logo

KPC Global Medical Centers INC.

Santa Ana, CA

  • RN
  • 12-⁠hour days
  • Per diem
Kindred Hospital Santa Ana logo

Kindred Hospital Santa Ana

Santa Ana, CA

  • CNA
  • FT Days

AltaMed Health Services Corporation

Santa Ana, CA

  • RN
  • Day shift
  • Tuition reimbursement

South Coast Post Acute TRC

Santa Ana, CA

RN

Posted last week

$52/hr

  • New grads welcomed
  • RN
Phoenix House Orange County logo

Phoenix House Orange County

Santa Ana, CA

  • LVN
  • Per diem
MedQuest Health Services, Inc. logo

MedQuest Health Services, Inc.

Santa Ana, CA

  • RN

a45074b6-b45e-424e-9e71-c45a4d73c34b

Santa Ana, CA

  • RN
  • Day shift
  • Per diem
Clarvida logo

Clarvida

Santa Ana, CA

Clinical Manager

$87,000–$90,000/year

  • RN
  • Day shift
  • CEU allowance
NeuroRestorative logo

NeuroRestorative

Santa Ana, CA

Registered Nurse

$38–$48/hr

  • RN
  • Full-time NOC shift; 7:00 pm to 7:30 am
  • +$2/hr differential

Kindred Healthcare

Santa Ana, CA

Registered Nurse FT Nights

Posted last week

$44–$56/hr

  • RN
  • FT Nights
  • Compact license OK
DaVita Kidney Care logo

DaVita Kidney Care

Santa Ana, CA

Registered Nurse

$40–$55/hr

  • RN
  • Rotating shift
  • outpatient dialysis
Kindred Hospitals logo

Kindred Hospitals

Santa Ana, CA

Registered Nurse RN FT ICU Nights

Posted last week

$51–$64/hr

  • Sign-on bonus
  • RN
  • Night shift
  • Per diem
Wellpath logo

Wellpath

Santa Ana, CA

Registered Nurse (RN)

Posted 5 days ago

  • RN

VITAS Healthcare

Santa Ana, CA

Hospice Aide- CNA/HHA

Posted 2 weeks ago

  • CNA
  • Day shift
Davita logo

Davita

Santa Ana, CA

Registered Nurse

$40–$55/hr

  • RN
Providence logo

Providence

Santa Ana, CA · Health system employer

  • LPN/LVN

AltaMed Health Services Corporation

Santa Ana, CA

Home Care Coordinator-CNA

Posted last week

$25/hr

  • CNA
  • Day shift

a45074b6-b45e-424e-9e71-c45a4d73c34b

Santa Ana, CA

  • RN
  • Night shift
  • Per diem
Kindred Hospitals logo

Kindred Hospitals

Santa Ana, CA

Registered Nurse FT Nights

Posted last week

$44–$56/hr

  • RN
  • Night shift
Wellpath logo

Wellpath

Santa Ana, CA

  • LVN

a45074b6-b45e-424e-9e71-c45a4d73c34b

Santa Ana, CA

  • RN
  • Night shift
  • Per diem
Kindred Hospitals logo

Kindred Hospitals

Santa Ana, CA

  • CNA
  • Day shift
Wellpath logo

Wellpath

Santa Ana, CA

Registered Nurse (RN)

Posted last week

  • RN

a45074b6-b45e-424e-9e71-c45a4d73c34b

Santa Ana, CA

  • RN
  • Night shift
  • Per diem
Wellpath logo

Wellpath

Santa Ana, CA

  • LVN
Wellpath logo

Wellpath

Santa Ana, CA

  • RN
  • Per diem
  • Tuition reimbursement

Working and living in Santa Ana

· 39 open roles

Posted hourly pay

RN
$44/hr median
$43–$47/hr middle half · 11 postings

See roles with listed pay

Living costs

Median gross rent
$2,082/mo
Rent and tenant-paid utilities
Median household income
$93,999/yr
All local households, not nurse pay

Census ACS 2024

Open to new grads

1 postings explicitly welcome new grads.

Browse new grad roles

New to our board this week

6 current postings first appeared here in the past seven days.

Browse current openings

Credentials accepted

  • RN31
  • LPN3
  • LVN6
  • CNA4

One posting may accept more than one credential.

Shifts listed

  • Days14
  • Nights13
  • per-diem3
  • Rotating1

Postings may list several shifts or leave the shift unspecified.

Living in Santa Ana

Santa Ana stands out as the historic and cultural heart of Orange County, offering relocating nurses a deeply authentic, energetic urban core distinct from the master-planned suburbs surrounding it.

More about life here

Healthcare professionals can base themselves in walkable downtown lofts near the Artists Village, historic Spanish Revival homes in Washington Square and Floral Park, or modern mid-rise complexes in South Coast Metro. Centrally located along Interstate 5 and State Route 55, the city provides straightforward access to major healthcare networks across central and coastal Orange County, though peak-hour freeway congestion demands careful schedule planning.

Off-shift hours can be spent exploring the 4th Street Market food hall, dining at Michelin-recognized spots like Lola Gaspar, touring world-class exhibitions at the Bowers Museum, or biking along the Santa Ana River Trail toward Newport and Huntington beaches. While prospective residents must navigate Southern California's high living expenses, urban density, and neighborhood-to-neighborhood variability, Santa Ana delivers unmatched local character, rich cultural traditions, and premier regional connectivity.

Sources
As of Sep 16, 2026
Neighborhoods

Downtown Santa Ana and the adjacent Artists Village cater to those wanting an urban lifestyle, offering converted historic lofts, mid-rise complexes, and walkable access to galleries and night markets. Floral Park and the Washington Square Historic District feature quiet, tree-lined residential streets populated by restored craftsman bungalows and Spanish Revival homes.

Park Santiago provides a scenic, established neighborhood feel near recreational trails, while the South Coast Metro area on the southern border offers modern apartment communities close to major corporate offices and upscale shopping hubs.

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Housing

Housing options in Santa Ana are varied, spanning single-family historic craftsman homes and Spanish Revival architecture in northern pockets like Floral Park to live-work lofts and converted boutique residential buildings downtown. Dense, multi-story mid-rise apartment communities and condominiums cluster in the South Coast Metro district near major commercial centers.

Over half the local population rents, giving newcomers a selection of both older courtyard properties and newer managed apartment developments.

Sources
Getting around

Santa Ana sits at the nexus of Orange County's highway grid, centered on Interstate 5 with direct access to State Route 55, State Route 22, and nearby Interstate 405, allowing rapid access to regional healthcare hubs in Anaheim, Orange, and Irvine. Rush-hour congestion along the I-5 and SR-55 corridors is frequent and can significantly extend shift commutes.

Public transit is anchored by the Santa Ana Regional Transportation Center, serving Metrolink passenger trains and regional bus routes, though personal vehicles remain essential for most healthcare workers navigating rotating hospital schedules.

Sources
Food and dining

The culinary scene centers on Fourth Street—locally known as La Cuatro—and the historic downtown core, home to communal gathering spaces like 4th Street Market and McFadden Public Market. Acclaimed local spots range from Michelin-recognized handmade tortillas and tapas at Lola Gaspar to Mexican-Szechuan fusion broth at Kaizen shabu-shabu and casual dining at Super Panga.

The city also features independent third-wave coffee shops, vibrant michelada spots, craft beer taprooms, and swift access to authentic Vietnamese fare in adjacent Little Saigon.

Sources
Outdoors

Outdoor activity centers around the Santa Ana River Trail, a paved multi-use pathway popular with distance runners and cyclists that connects inland Orange County down toward Pacific beaches. Santiago Park offers wooded, hilly walking paths, neighborhood sports facilities, and shaded picnic lawns.

In addition, residents benefit from quick driving access to coastal recreation spots including Newport Beach and Huntington Beach for surfing and coastal walks.

Sources
Arts and culture

Santa Ana functions as the cultural capital of Orange County, anchored by the monthly First Saturday Artwalk, more than two hundred historic and contemporary murals, and creative spaces like Crear Studio and Grand Central Art Center. Landmark institutions include the Bowers Museum, the interactive Discovery Cube Orange County, and the historic Heritage Museum of Orange County.

Nightlife and live entertainment center on the historic Yost Theater downtown and the nearby Observatory music venue.

Sources
Seasons and weather

Santa Ana experiences a mild Mediterranean climate characterized by year-round sunshine and low humidity. Summers are warm and dry, with coastal marine layers often providing morning cloud cover before burning off by midday.

Winters remain comfortable with occasional rain showers, while autumn frequently brings warm days tempered by dry regional winds.

Sources
For families

Family-oriented neighborhoods include Park Santiago, Floral Park, and adjacent residential tracts near Tustin, known for mature trees and neighborhood parks. The local education landscape features specialized programs such as Jim Thorpe Fundamental, Arroyo Elementary, and the acclaimed Orange County School of the Arts (OCSA), alongside private institutions like Mater Dei High School.

Family recreation is supported by hands-on STEM programming at Discovery Cube Orange County, local exhibits at the Santa Ana Zoo, and neighborhood sports facilities.

Sources
What locals say

Residents praise Santa Ana for its authentic community spirit, walkable downtown core, and rich Latino cultural heritage, highlighting its dynamic food scene and arts presence as refreshing alternatives to surrounding planned suburbs. On the other hand, locals consistently point to intense freeway traffic on the 5 and 55, pockets of street-level urban friction, and the general affordability pressures typical of Southern California as regular challenges.

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