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48 nursing jobs in Yankton, SD

Yankton sits along the Missouri River near Lewis and Clark Lake, offering nurses a quiet, outdoorsy lifestyle in a historic South Dakota river town. Expect a close-knit community feel, easy commutes, and abundant fishing, boating, and trail access—ideal for those who prefer small-town living with natural amenities over urban bustle.

Yankton, SD on the map· Open the live map
Sacred Heart Health Services workplace
Sacred Heart Health Services — a workplace named in a current Yankton postingView Sacred Heart Health Services →

Find a nursing job in Yankton

Hiring here: Sacred Heart Health Services (36) · Avera McKennan (5) · Vibra Travels LLC (2) · American Traveler (1) · Avera (1) · Avera Health (1)

Sacred Heart Health Services

Yankton, SD

  • NP
  • Day Shift (United States of America)
1 / 3
  • Sign-on bonus
  • CNA
  • 12-⁠hour nights
  • New grads welcomed · reported
1 / 2

Registered Nurse (RN) | Oncology Clinic

Avera McKennan logoAvera McKennan

Yankton, SD

$28/hr

  • Sign-on bonus
  • RN
  • Monday-Friday, days; 40 hours a week
  • Tuition reimbursement

Sacred Heart Health Services

Yankton, SD

  • NP
  • Day shift
Avera McKennan logo

Avera McKennan

Yankton, SD

  • Sign-on bonus
  • RN
  • Monday-Friday, 3 days per week
  • Tuition reimbursement
1 / 2

Registered Nurse (RN) Float | Med Surg

Sacred Heart Health Services

Yankton, SD · Posted last week

$35/hr

  • Sign-on bonus
  • RN
  • 7pm-7am & 7am-7pm; 72hrs/2wks; Every 3rd weekend/holiday
  • Tuition reimbursement
Avera McKennan logo

Avera McKennan

Yankton, SD

  • RN
  • PRN/fill in as needed; Monday-Friday, Days
  • Per diem

Sacred Heart Health Services

Yankton, SD

  • Sign-on bonus
  • CNA
  • 8-⁠hour days
Avera McKennan logo

Avera McKennan

Yankton, SD

  • Sign-on bonus
  • RN
  • Monday-Thursday 8am-5pm & Friday 8am-12pm; 72hrs/2wks
  • Tuition reimbursement

Sacred Heart Health Services

Yankton, SD

  • Sign-on bonus
  • RN
  • Rotating shift
  • Tuition reimbursement
Avera McKennan logo

Avera McKennan

Yankton, SD

  • RN
  • Days, Monday-Friday; 40hrs/2wks
A photo of Sacred Heart Health Services

Sacred Heart Health Services

31 open roles

  • Sign-on bonus
  • RN
  • 8-⁠hour days
  • Tuition reimbursement
  • Sign-on bonus
  • RN
  • 7pm-7am & 7am-7pm; 72hrs/2wks; Every 3rd weekend/holiday
  • Tuition reimbursement
  • Sign-on bonus
  • RN
  • Day shift
  • Tuition reimbursement
  • Sign-on bonus
  • CNA
  • 5:30pm-6am; Every 3rd weekend/holiday rotation; 72hrs/pp
  • Floating required
  • Sign-on bonus
  • LPN
  • Days - 8am-5pm (flexible); Every 6th weekend/holiday rotation
  • Tuition reimbursement
  • Sign-on bonus
  • RN/LPN
  • 7pm-7am & 7am-7pm; 72hrs/2wks; Every 3rd weekend/holiday
  • Tuition reimbursement
  • Sign-on bonus
  • RN
  • Rotating shift
  • Tuition reimbursement
  • RN
  • Day shift
  • Tuition reimbursement

Registered Nurse (RN) | Pre-Post Operative

Yankton, SD · Posted 4 days ago

  • RN
  • 8-⁠hour shifts
  • Sign-on bonus
  • RN/LPN
  • Day shift: 6am-6:30pm; Every 3rd weekend/holiday, 48hrs/2wks
  • Tuition reimbursement

Registered Nurse (RN) FLOAT | Med Surg

Yankton, SD · Posted 5 days ago

  • Sign-on bonus
  • RN
  • Rotating shift
  • RN
  • Rotating shift

Registered Nurse (RN) | Emergency Unit

Yankton, SD · Posted 5 days ago

  • Sign-on bonus
  • RN
  • Rotating shift
  • Sign-on bonus
  • RN/LPN
  • Night shift: 6pm-6:30am; Every 3rd weekend/holiday, 72hrs/2wks
  • Tuition reimbursement
  • Sign-on bonus
  • CNA
  • Rotating shift
  • Sign-on bonus
  • RN/LPN
  • Monday-Friday, Days; 40 hours a week
  • Tuition reimbursement
  • Sign-on bonus
  • CNA
  • Night shift
  • RN/LPN
  • PRN/fill in as needed; Monday-Friday, days
  • Per diem

Registered Nurse (RN) | Long Term Care

Yankton, SD · Posted last week

  • Sign-on bonus
  • RN
  • Day shift
  • Sign-on bonus
  • RN
  • 7pm-7am & 7am-7pm; 48hrs/2wks; Every 3rd weekend/holiday
  • Tuition reimbursement

Registered Nurse (RN) Quality Specialist

Yankton, SD · Posted last week

  • RN
  • Day shift
  • Sign-on bonus
  • RN
  • Monday - Friday, 3 shifts per week; 48hrs/2wks
  • Tuition reimbursement

Registered Nurse (RN) | Podiatry Clinic

Yankton, SD · Posted last week

  • Sign-on bonus
  • RN
  • Day shift
  • Sign-on bonus
  • RN/LPN
  • Monday-Friday, Days; 40 hours a week
  • Tuition reimbursement
  • RN
  • 12-⁠hour nights
  • New grads welcomed
  • RN
  • Rotating shift
  • Per diem
  • Sign-on bonus
  • CNA
  • 6am-6:30pm; Every 3rd weekend/holiday rotation; 72hrs/pp
  • Floating required
  • New grads welcomed
  • RN
  • 6am-6:30pm; 3-12hr shifts per week, Every 3rd weekend/holiday rotation
  • Per diem

Kore Cares

Yankton, SD

  • LPN
  • Day shift
Avera logo

Avera

Yankton, SD

  • RN
  • Day shift
  • Per diem

State of South Dakota

Yankton, SD

  • Sign-on bonus
  • RN
  • 12-⁠hour rotating
  • Compact license OK
Vibra Travels LLC logo

Vibra Travels LLC

Yankton, SD · Staffing partner

  • RN
American Traveler logo

American Traveler

Yankton, SD · Staffing partner

  • RN
  • 12-⁠hour nights
  • Travel contract
Vibra Travels LLC logo

Vibra Travels LLC

Yankton, SD · Staffing partner

RN - ER

$3,221/week

  • RN
  • Travel contract

Working and living in Yankton

· 48 open roles

Posted hourly pay

RN
$28/hr median
$25–$33/hr middle half · 23 postings
LPN
$25/hr median
$23–$25/hr middle half · 9 postings
CNA
$20/hr median
$20–$20/hr middle half · 5 postings

See roles with listed pay

Open to new grads

3 postings explicitly welcome new grads.

Browse new grad roles

New to our board this week

7 current postings first appeared here in the past seven days.

Browse current openings

Credentials accepted

  • NP2
  • RN36
  • LPN9
  • CNA8

One posting may accept more than one credential.

Shifts listed

  • Days23
  • Rotating13
  • Nights7
  • per-diem1

Postings may list several shifts or leave the shift unspecified.

Living in Yankton

Positioned along the Missouri River in southeastern South Dakota, Yankton combines small-town community warmth with regional healthcare importance.

More about life here

For relocating nurses, Avera Sacred Heart Hospital serves as a major employer anchored within a community of roughly 15,000 residents. Daily life offers seamless logistics: average commutes run approximately 9 minutes, eliminating stressful urban traffic.

Off duty, life centers around the water. Lewis and Clark Lake, the Lewis and Clark Recreation Area, and the iconic pedestrian Meridian Bridge provide exceptional boating, fishing, and trail walking right at your doorstep.

The historic downtown features cultural stops like the G.A.R. Hall Gallery and dining favorites like Willa B's Bistro and Chaparro's Tacos. The trade-offs reflect its small scale: public transit is minimal, requiring a personal vehicle, and winter brings substantial snow alongside quiet nightlife that mostly wraps up early.

For clinicians seeking outdoor recreation and an unhurried daily rhythm, Yankton offers a grounded, welcoming river-town lifestyle.

Sources
As of Oct 8, 2026
Neighborhoods

Residential living in Yankton centers around established residential corridors along streets like Douglas Avenue near Mount Marty University, quiet pockets such as Castlewood Circle and Bunker Lane, and riverside neighborhoods adjacent to Riverside Park and historic downtown. Outlying residential pockets extend west toward Lewis and Clark Lake, where resort-style and recreational properties appeal to those seeking scenic water views.

Sources
Housing

Housing in Yankton is dominated by established single-family homes with mature yards, alongside modest rental clusters situated near Mount Marty University and Avera Sacred Heart Hospital. Neighborhoods range from older craftsman and mid-century homes in central districts along avenues like Douglas to newer suburban builds and cul-de-sacs.

Premium properties are typically found west of town near Lewis and Clark Lake.

Sources
Getting around

Commutes in Yankton are exceptionally quick, averaging roughly 9 minutes across town. Healthcare workers commuting to Avera Sacred Heart Hospital or Mount Marty University face virtually no highway gridlock.

Daily travel is overwhelmingly car-oriented, as public transit is limited to select dial-a-ride or specialized services, and local bike routes are largely geared toward recreational trail riding rather than utility transit.

Sources
Food and dining

Yankton's dining revolves around independent local favorites in the historic downtown district and near the riverfront. Notable staples include casual spots like Willa B's Bistro, authentic street food at Chaparro's Tacos, and waterfront dining near the marina at The Boat House.

While traditional Midwestern fare and local diners are easy to find, late-night options after evening nursing shifts are limited.

Sources
Outdoors

Outdoor recreation is Yankton's defining feature, anchored by Lewis and Clark Lake and the Missouri River. Residents frequent the Lewis and Clark Recreation Area for camping, boating, and beach outings, as well as the Lewis and Clark Resort.

In town, Riverside Park provides paved riverfront multi-use trails, and the double-deck pedestrian Meridian Bridge offers walking and biking across the Missouri River, while anglers head to Gavins Point National Fish Hatchery.

Sources
Arts and culture

Yankton's cultural offerings emphasize pioneer history and regional fine art. Downtown showcases rotating murals, seasonal studio tours, and art walks, while the G.A.R. Hall Gallery and Cultural Center displays monthly exhibitions from regional creators.

History buffs also explore the Dakota Territorial Capitol Replica in Riverside Park, commemorating Yankton's role as the initial capital of Dakota Territory.

Sources
Seasons and weather

Residents experience distinct four-season Northern Plains weather. Winters are cold and windy, bringing an average of 35 inches of snowfall that demands winter driving preparation.

Springs and autumns are brief but pleasant, leading into warm summer months that average 27 inches of annual rainfall and create prime conditions for boating and water recreation on the lake.

Sources
As of Oct 8, 2026Source: livability.com
For families

Yankton provides a quiet, family-oriented environment characterized by low noise and a strong, rooted resident base. Primary and secondary education is administered through the Yankton School District, complemented by private parochial schools and higher education at Mount Marty University.

Family entertainment includes Riverside Park playgrounds, outings along Lewis and Clark Lake, and Karttrax Go-Kart & Family Fun Park.

Sources
What locals say

Community discussions characterize Yankton as a safe, peaceful river community with deep small-town charm and unparalleled access to boating, hunting, and fishing. Longtime residents value the calm atmosphere and strong local hospital infrastructure.

On the downside, some newcomers and online commenters note a slower social pace, limited nightlife options outside outdoor recreation, and occasional frustrations with civic management.

Sources

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