431 nursing jobs in Sioux Falls, SD
Anchored by major health systems like Sanford and Avera, Sioux Falls delivers serious regional clinical volume alongside a cost of living about 9% below the national average. Trade grinding gridlock for easy commutes along the Big Sioux River, decompressing around downtown’s Phillips Avenue and Falls Park. Here, your nursing scope and paycheck both stretch remarkably far.
Find a nursing job in Sioux Falls
Hiring here: Avera McKennan (113) · Sanford Health (107) · Sanford (62) · The Evangelical Lutheran Good Samaritan Society (39) · Veterans Health Administration (36) · Good Samaritan (14)
Registered Nurse (RN) or Licensed Practical Nurse (LPN) | Gastroenterology Clinic
Posted 6 days ago
$23–$41/hr
- Sign-on bonus
- RN/LPN
Nurse Practitioner or Physician Assistant | Urgent Care
Sioux Falls, SD · Posted 2 weeks ago
- NP
- Rotating shift
- Per diem
- RN
- Primarily days with possible weekends/evenings/holidays
Nurse Practitioner or Physician Assistant | Neurology | Inpatient
Posted 2 weeks ago
- NP
- Day/Evening/Weekend/Holiday Shift (United States of America)
- LPN
- 40 hours a week 0930-1800. Monday through Friday.
- NP
- Rotating shift
Certified Nurse Midwife
Sioux Falls, SD · Posted last week
- CNM
- Day/Evening/Weekend/Holiday Shift (United States of America)
- RN
- 8-hour days
- Sign-on bonus
- RN
- 0700-1930/1930-0700 rotating shifts, every other weekend (Fri/Sat/Sun)
- Sign-on bonus
- RN
- Ratio 1:4–1:5
- Rotating shift
- Sign-on bonus
- RN
- Night shift
- Compact license OK
Registered Nurse - Nights
$41–$45/hr
- RN
- 12-hour nights
- RN
- 10-hour days
- Device Clinic
- RN/LPN
- Per diem
- RN
- Weekend shift
- Per diem
- LPN
- Day shift
- New grads welcomed
- RN
- 12-hour days
- Compact license OK
- RN
- As Needed
- Per diem
- NP
- 8-hour days
- New grads welcomed
- RN
- 8-hour shifts
- Compact license OK
RN - Part Time PMs - SF Village
$34–$48/hr
- Sign-on bonus
- RN
- 2:00 pm – 10:30 pm
- Compact license OK
Registered Nurse (DAY SHIFT ONLY) (SDSP)
$33–$39/hr
- Sign-on bonus
- NP
- Day shift
- Compact license OK
- RN
- Day shift
- Avera Comprehensive Breast Care Sioux Falls
- RN
- Day shift
- Travel contract
- Sign-on bonus
- RN
- Night shift
- Compact license OK
- Sign-on bonus
- RN
- Day shift
- NP
- 10-hour shifts
- RN
- 3 12 hour shifts per week. No weekends or holidays
- Compact license OK
- RN
- 12-hour days
- Compact license OK
Working and living in Sioux Falls
· 431 open roles
Posted hourly pay
- RN
- $32/hr median
- $28–$33/hr middle half · 174 postings
- LPN
- $22/hr median
- $20–$23/hr middle half · 76 postings
- CNA
- $19/hr median
- $19–$20/hr middle half · 10 postings
Living costs
- Median gross rent
- $1,035/mo
- Rent and tenant-paid utilities
- Median household income
- $75,970/yr
- All local households, not nurse pay
New to our board this week
36 current postings first appeared here in the past seven days.
Credentials accepted
- CRNA1
- CNM1
- NP19
- APRN1
- RN300
- LPN119
- LVN4
- CNA22
One posting may accept more than one credential.
Shifts listed
- Days239
- Rotating88
- Nights34
- Evenings21
- per-diem10
- weekend1
Postings may list several shifts or leave the shift unspecified.
Living in Sioux Falls
Sioux Falls is South Dakota's largest city (about 210,000 people), a compact Big Sioux River town where health care is a leading industry and the namesake falls sit in the urban core at Falls Park.
More about life hereShow less
Daily life is unusually short-commute: about 16 minutes on average, with the University and Hospital area letting nurses bike or walk to work. A 30-mile paved river trail ties together more than 80 parks.
Downtown mixes condos and historic homes within walking distance of SculptureWalk, First Friday, the 1926 State Theatre, Monk's Ale House, and Minerva's; East and Southwest Sioux Falls are the affordable, family-and-first-buyer belts, while West Sioux Falls and downtown run more premium. U.S. News lists median home value at $315,740 and median rent at $880. Expect brutal, windy winters, hot summers, tornado risk, and a city that can feel isolated from other metros—offset by a clean, friendly downtown, Saturday Falls Park markets, Washington Pavilion arts and science, and outdoor space locals use in every season.
Sources
Neighborhoods
Nurses and hospital-area workers often land in the University and Hospital District so they can bike or walk to work. Downtown Sioux Falls is a top pick for low-maintenance living—modern condos mixed with historic homes—plus walkability to restaurants, shopping, and cultural amenities, and it is frequently recommended for empty nesters as well as urban professionals.
Southwest Sioux Falls is the family-oriented area with parks and strong schools; East Sioux Falls offers more affordable homes and newer developments aimed at first-time buyers; Northeast is quieter, with larger homes and more privacy still close to the center. West Sioux Falls skews newer construction and a higher budget, while locals mention Lake Loraine as a cheaper cost-of-living pocket.
Housing
U.S. News puts the median home value at $315,740 against a $359,870 national average, with median rent at $880 and a lower housing-cost burden than similarly sized metros. East Sioux Falls and Southwest Sioux Falls are the neighborhoods called out for affordable and first-time-buyer homes; Downtown (condos and historic houses) and West Sioux Falls are the more upscale or new-construction choices.
Central Sioux Falls mixes older stock and new builds that investors watch for rentals; Lake Loraine is mentioned for cheaper living. Property taxes are described as among the lowest in the country.
Getting around
The typical Sioux Falls commute is about 16.2 minutes, and the city is described as easy to navigate, with destinations rarely far apart. Living in the University and Hospital area is the local advice if you want to bike or walk instead of drive to medical campuses.
Sources here do not name transit lines, hospital parking rules, or specific highway approaches.
Sources
Food and dining
Downtown is the clear restaurant and nightlife district, with community shout-outs for Simon's Tacos, Monk's Ale House, and Minerva's. On Saturdays, Falls Park Farmer's Market sets up at the falls with local produce, baked goods, artisan treats, food vendors, and kombucha.
Monthly First Friday adds live music and gallery-hopping to the same downtown streets. Sources do not inventory late-night kitchens next to the hospitals beyond that walkable University/Hospital-to-downtown corridor.
Sources
Outdoors
Falls Park is the free downtown centerpiece: more than 120 acres of waterfalls, historic ruins, and scenic trails. The Big Sioux River Recreation Trail runs a 30-mile paved loop that connects more than 80 city parks for biking, running, and walking in any season.
The Outdoor Campus in the Mall District has about 3 miles of walking trails and public classes; Flow and Paddle sits in Southwest; the Great Plains Zoo & Delbridge Museum of Natural History and the Butterfly House & Aquarium round out nature time. The Arc of Dreams, a stainless-steel sculpture spanning the Big Sioux River, is a popular landmark.
Arts and culture
SculptureWalk installs a rotating collection of more than 50 works along downtown sidewalks, turning the core into an open-air gallery. The State Theatre, a restored 1926 vaudeville house, screens new and classic films.
Washington Pavilion houses the Visual Arts Center (described as South Dakota's largest art museum), the Kirby Science Discovery Center, Broadway shows, a planetarium, and movies. First Friday each month brings gallery openings, live music, and art demonstrations, and the fall Sidewalk Arts Festival fills downtown with hundreds of artists selling fine art, folk art, and crafts.
Sources
Seasons and weather
Plan on four sharp seasons: hot summers and cold, snowy winters. Brutal winter is the first item on local don't-move-here-unless-you-can-handle-this lists, and newcomers also flag a windy climate.
Tornadoes are part of the South Dakota package; residents note a good warning system and the need to be prepared. People who stay lean into snow sports and indoor life in winter, while the paved river trail is marketed as a year-round outlet.
For families
Southwest Sioux Falls is the neighborhood most often sold as family-friendly—spacious homes, excellent schools, and parks. Community posts call the whole city extremely family-friendly, clean, and safe, with good or competitive schools and more than 80 parks.
Kid-ready anchors include the Great Plains Zoo, Butterfly House & Aquarium, Outdoor Campus programs, and the Saturday market at Falls Park. U.S. News ranks Sioux Falls the #1 place to live in South Dakota and #16 among Best Places to Retire, which matches the easy-to-raise-a-family local tone.
What locals say
Residents praise a cute, friendly, accessible downtown that is still growing, plus solid restaurants and bars and a fantastic bike-trail and park system. Newcomers and realtors call the city clean, safe, and family-friendly, with a real Midwestern-nice culture and a strong job market.
The consistent caveats are brutal winters, wind, hot summers, tornadoes, and a sense of isolation from other major cities. Some relocation chatter also warns that costs can feel higher than the cheap-Midwest stereotype even when housing sits below national medians.
