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431 nursing jobs in Sioux Falls, SD

Anchored by major health systems like Sanford and Avera, Sioux Falls delivers serious regional clinical volume alongside a cost of living about 9% below the national average. Trade grinding gridlock for easy commutes along the Big Sioux River, decompressing around downtown’s Phillips Avenue and Falls Park. Here, your nursing scope and paycheck both stretch remarkably far.

Sioux Falls, SD on the map· Open the live map
Avera Health workplace
Avera Health — a workplace named in a current Sioux Falls postingView Avera Health →

Find a nursing job in Sioux Falls

Hiring here: Avera McKennan (113) · Sanford Health (107) · Sanford (62) · The Evangelical Lutheran Good Samaritan Society (39) · Veterans Health Administration (36) · Good Samaritan (14)

Avera Health logo

Avera Health

Sioux Falls, SD

  • Sign-on bonus
  • RN/LPN
1 / 2
  • RN
1 / 2

Sioux Falls APRN Medical Cannabis Industry

My Marijuana Cards logoMy Marijuana Cards

Sioux Falls, SD

$50/hr

  • APRN
1 / 2

Nurse Practitioner or Physician Assistant | Urgent Care

Avera McKennan logoAvera McKennan

Sioux Falls, SD · Posted 2 weeks ago

  • NP
  • Rotating shift
  • Per diem
Avera Health logo

Avera Health

Sioux Falls, SD

Registered Nurse (RN) Clinical Quality Analyst

Posted last week

$64,000–$96,000/year

  • RN
  • Primarily days with possible weekends/evenings/holidays
Avera McKennan logo

Avera McKennan

Sioux Falls, SD

  • NP
  • Day/Evening/Weekend/Holiday Shift (United States of America)
Avera Health logo

Avera Health

Sioux Falls, SD

  • LPN
  • 40 hours a week 0930-1800. Monday through Friday.
Avera McKennan logo

Avera McKennan

Sioux Falls, SD

  • NP
  • Rotating shift
Avera Health logo

Avera Health

Sioux Falls, SD

  • RN
  • Day shift
1 / 2

Certified Nurse Midwife

Avera McKennan logoAvera McKennan

Sioux Falls, SD · Posted last week

  • CNM
  • Day/Evening/Weekend/Holiday Shift (United States of America)
Avera Health logo

Avera Health

Sioux Falls, SD

  • RN
  • Day shift
1 / 2

Nurse Practitioner | Neonatal

Avera McKennan logoAvera McKennan

Sioux Falls, SD

  • NP
  • Day/Evening/Weekend/Holiday Shift
1 / 3
  • RN
  • 8-⁠hour days
Avera McKennan logo

Avera McKennan

Sioux Falls, SD

Registered Nurse (RN) | NICU

Posted last week

$33/hr

  • Sign-on bonus
  • RN
  • 0700-1930/1930-0700 rotating shifts, every other weekend (Fri/Sat/Sun)
Avera McKennan logo

Avera McKennan

Sioux Falls, SD

  • NP
  • Day shift
Sioux Center Health logo

Sioux Center Health

Sioux Falls, SD · Health system employer

  • Sign-on bonus
  • RN
  • Ratio 1:4–1:5
  • Rotating shift
Avera logo

Avera

Sioux Falls, SD

  • RN
  • Day shift

South Dakota State Government

Sioux Falls, SD

  • Sign-on bonus
  • RN
  • Night shift
  • Compact license OK

Correctional Medical Management, LLC

Sioux Falls, SD

  • RN
  • 12-⁠hour nights
Sioux Falls School District logo

Sioux Falls School District

Sioux Falls, SD

School Nurse - 1.0 FTE

$54,000–$61,000/year

  • RN
  • 8-⁠hour days

Heart Hospital of South Dakota, LLC

Sioux Falls, SD

  • RN
  • 10-⁠hour days
  • Device Clinic
GPac logo

GPac

Sioux Falls, SD

  • RN
  • 12-⁠hour rotating
Turnwell Mental Health Network INC logo

Turnwell Mental Health Network INC

Sioux Falls, SD · Health system employer

  • RN
  • Weekend shift
  • Per diem

RAS Companies

Sioux Falls, SD

  • RN
Sioux Falls Specialty Hospital logo

Sioux Falls Specialty Hospital

Sioux Falls, SD

  • LPN
  • Day shift

Sanford Medical Center

Sioux Falls, SD

  • New grads welcomed
  • RN
  • 12-⁠hour days
  • Compact license OK

Avera at Home

Sioux Falls, SD

  • RN
  • As Needed
  • Per diem

City of Sioux Falls

Sioux Falls, SD

Registered Nurse

$34–$37/hr

  • Sign-on bonus
  • RN

PorchLight Services

Sioux Falls, SD

RN / LPN

$29–$40/hr

  • RN/LPN
  • 8-⁠hour 8 hour
TeamHealth logo

TeamHealth

Sioux Falls, SD

  • RN
  • Evening shift
  • Per diem
Limitless Male Medical logo

Limitless Male Medical

Sioux Falls, SD

  • RN/LPN
  • Day shift

Sanford Clinic

Sioux Falls, SD

  • NP
  • 8-⁠hour days
Sanford Health logo

Sanford Health

Sioux Falls, SD · Health system employer

  • New grads welcomed
  • RN
  • 8-⁠hour shifts
  • Compact license OK

Genie Healthcare

Sioux Falls, SD

RN, ICU

$63/hr

  • RN
  • 12-⁠hour nights
  • Travel contract
Good Samaritan logo

Good Samaritan

Sioux Falls, SD

  • Sign-on bonus
  • RN
  • 2:00 pm – 10:30 pm
  • Compact license OK

State of South Dakota

Sioux Falls, SD

  • Sign-on bonus
  • NP
  • Day shift
  • Compact license OK
Avera Health logo

Avera Health

Sioux Falls, SD

  • LPN
  • 12-⁠hour rotating
Sioux Center Health logo

Sioux Center Health

Sioux Falls, SD · Health system employer

  • RN
  • Day shift
  • Avera Comprehensive Breast Care Sioux Falls

Avera

Sioux Falls, SD

  • RN
  • Day shift
  • Travel contract

South Dakota State Government

Sioux Falls, SD

  • Sign-on bonus
  • RN
  • Night shift
  • Compact license OK
Limitless Male logo

Limitless Male

Sioux Falls, SD

  • RN/LPN
  • Day shift

Avera at Home

Sioux Falls, SD

  • Sign-on bonus
  • RN
  • Day shift

Sanford Clinic

Sioux Falls, SD

  • NP
  • 10-⁠hour shifts
Sioux Center Health logo

Sioux Center Health

Sioux Falls, SD · Health system employer

  • RN
  • 3 12 hour shifts per week. No weekends or holidays
  • Compact license OK
Avera logo

Avera

Sioux Falls, SD

  • RN
  • Day shift
  • Per diem
Sioux Center Health logo

Sioux Center Health

Sioux Falls, SD · Health system employer

  • RN
  • 12-⁠hour days
  • Compact license OK

Working and living in Sioux Falls

· 431 open roles

Posted hourly pay

RN
$32/hr median
$28–$33/hr middle half · 174 postings
LPN
$22/hr median
$20–$23/hr middle half · 76 postings
CNA
$19/hr median
$19–$20/hr middle half · 10 postings

See roles with listed pay

Living costs

Metro price level
90.6 (100 = national)
BEA 2024
Median gross rent
$1,035/mo
Rent and tenant-paid utilities
Median household income
$75,970/yr
All local households, not nurse pay

Census ACS 2024

Open to new grads

58 postings explicitly welcome new grads.

Browse new grad roles

New to our board this week

36 current postings first appeared here in the past seven days.

Browse current openings

Credentials accepted

  • CRNA1
  • CNM1
  • NP19
  • APRN1
  • RN300
  • LPN119
  • LVN4
  • CNA22

One posting may accept more than one credential.

Shifts listed

  • Days239
  • Rotating88
  • Nights34
  • Evenings21
  • per-diem10
  • weekend1

Postings may list several shifts or leave the shift unspecified.

Living in Sioux Falls

Sioux Falls is South Dakota's largest city (about 210,000 people), a compact Big Sioux River town where health care is a leading industry and the namesake falls sit in the urban core at Falls Park.

More about life here

Daily life is unusually short-commute: about 16 minutes on average, with the University and Hospital area letting nurses bike or walk to work. A 30-mile paved river trail ties together more than 80 parks.

Downtown mixes condos and historic homes within walking distance of SculptureWalk, First Friday, the 1926 State Theatre, Monk's Ale House, and Minerva's; East and Southwest Sioux Falls are the affordable, family-and-first-buyer belts, while West Sioux Falls and downtown run more premium. U.S. News lists median home value at $315,740 and median rent at $880. Expect brutal, windy winters, hot summers, tornado risk, and a city that can feel isolated from other metros—offset by a clean, friendly downtown, Saturday Falls Park markets, Washington Pavilion arts and science, and outdoor space locals use in every season.

Sources
As of Sep 11, 2026
Neighborhoods

Nurses and hospital-area workers often land in the University and Hospital District so they can bike or walk to work. Downtown Sioux Falls is a top pick for low-maintenance living—modern condos mixed with historic homes—plus walkability to restaurants, shopping, and cultural amenities, and it is frequently recommended for empty nesters as well as urban professionals.

Southwest Sioux Falls is the family-oriented area with parks and strong schools; East Sioux Falls offers more affordable homes and newer developments aimed at first-time buyers; Northeast is quieter, with larger homes and more privacy still close to the center. West Sioux Falls skews newer construction and a higher budget, while locals mention Lake Loraine as a cheaper cost-of-living pocket.

Sources
Housing

U.S. News puts the median home value at $315,740 against a $359,870 national average, with median rent at $880 and a lower housing-cost burden than similarly sized metros. East Sioux Falls and Southwest Sioux Falls are the neighborhoods called out for affordable and first-time-buyer homes; Downtown (condos and historic houses) and West Sioux Falls are the more upscale or new-construction choices.

Central Sioux Falls mixes older stock and new builds that investors watch for rentals; Lake Loraine is mentioned for cheaper living. Property taxes are described as among the lowest in the country.

Sources
Getting around

The typical Sioux Falls commute is about 16.2 minutes, and the city is described as easy to navigate, with destinations rarely far apart. Living in the University and Hospital area is the local advice if you want to bike or walk instead of drive to medical campuses.

Sources here do not name transit lines, hospital parking rules, or specific highway approaches.

Sources
Food and dining

Downtown is the clear restaurant and nightlife district, with community shout-outs for Simon's Tacos, Monk's Ale House, and Minerva's. On Saturdays, Falls Park Farmer's Market sets up at the falls with local produce, baked goods, artisan treats, food vendors, and kombucha.

Monthly First Friday adds live music and gallery-hopping to the same downtown streets. Sources do not inventory late-night kitchens next to the hospitals beyond that walkable University/Hospital-to-downtown corridor.

Sources
Outdoors

Falls Park is the free downtown centerpiece: more than 120 acres of waterfalls, historic ruins, and scenic trails. The Big Sioux River Recreation Trail runs a 30-mile paved loop that connects more than 80 city parks for biking, running, and walking in any season.

The Outdoor Campus in the Mall District has about 3 miles of walking trails and public classes; Flow and Paddle sits in Southwest; the Great Plains Zoo & Delbridge Museum of Natural History and the Butterfly House & Aquarium round out nature time. The Arc of Dreams, a stainless-steel sculpture spanning the Big Sioux River, is a popular landmark.

Sources
Arts and culture

SculptureWalk installs a rotating collection of more than 50 works along downtown sidewalks, turning the core into an open-air gallery. The State Theatre, a restored 1926 vaudeville house, screens new and classic films.

Washington Pavilion houses the Visual Arts Center (described as South Dakota's largest art museum), the Kirby Science Discovery Center, Broadway shows, a planetarium, and movies. First Friday each month brings gallery openings, live music, and art demonstrations, and the fall Sidewalk Arts Festival fills downtown with hundreds of artists selling fine art, folk art, and crafts.

Sources
Seasons and weather

Plan on four sharp seasons: hot summers and cold, snowy winters. Brutal winter is the first item on local don't-move-here-unless-you-can-handle-this lists, and newcomers also flag a windy climate.

Tornadoes are part of the South Dakota package; residents note a good warning system and the need to be prepared. People who stay lean into snow sports and indoor life in winter, while the paved river trail is marketed as a year-round outlet.

Sources
For families

Southwest Sioux Falls is the neighborhood most often sold as family-friendly—spacious homes, excellent schools, and parks. Community posts call the whole city extremely family-friendly, clean, and safe, with good or competitive schools and more than 80 parks.

Kid-ready anchors include the Great Plains Zoo, Butterfly House & Aquarium, Outdoor Campus programs, and the Saturday market at Falls Park. U.S. News ranks Sioux Falls the #1 place to live in South Dakota and #16 among Best Places to Retire, which matches the easy-to-raise-a-family local tone.

Sources
What locals say

Residents praise a cute, friendly, accessible downtown that is still growing, plus solid restaurants and bars and a fantastic bike-trail and park system. Newcomers and realtors call the city clean, safe, and family-friendly, with a real Midwestern-nice culture and a strong job market.

The consistent caveats are brutal winters, wind, hot summers, tornadoes, and a sense of isolation from other major cities. Some relocation chatter also warns that costs can feel higher than the cheap-Midwest stereotype even when housing sits below national medians.

Sources

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