10 nursing jobs in De Soto, MO
Find a nursing job in De Soto
Hiring here: Stonebridge DeSoto (6) · Stone Bridge Senior Living (2) · Sunnyhill Inc. (1) · United Energy Workers Healthcare (1)
Community-Based Registered Nurse (RN) in Jefferson County
$65,000–$90,000/year
- Sign-on bonus
- RN
- New grads welcomed · reported
Registered Nurse- Night Shift
Posted last week
- Sign-on bonus
- RN
- Night shift
- Tuition reimbursement
Stonebridge DeSoto
5 open roles · day & night shifts · Permanent
Stonebridge DeSoto
5 open roles · day & night shifts · Permanent
Registered Nurse- Day Shift
De Soto, MO · Posted last week
- Sign-on bonus
- RN
- Day shift
- Tuition reimbursement
Registered Nurse- Night Shift
De Soto, MO
- RN
- Night shift
- Tuition reimbursement
Registered Nurse- Day Shift
De Soto, MO
- RN
- Day shift
- Tuition reimbursement
Registered Nurse- Day Shift
De Soto, MO
- RN
- Day shift
- Tuition reimbursement
Registered Nurse- Night Shift
De Soto, MO
- RN
- Night shift
- Tuition reimbursement
Working and living in De Soto
· 10 open roles
Living costs
- Median gross rent
- $809/mo
- Rent and tenant-paid utilities
- Median household income
- $52,500/yr
- All local households, not nurse pay
New to our board this week
0 current postings first appeared here in the past seven days.
Credentials accepted
- RN8
- LPN2
One posting may accept more than one credential.
Shifts listed
- Days4
- Nights4
Postings may list several shifts or leave the shift unspecified.
Living in De Soto
De Soto, historically nicknamed the Fountain City, offers relocating healthcare workers a calm, grounded lifestyle roughly 45 miles south of St. Louis in Jefferson County.
More about life hereShow less
Originally platted as a 19th-century railroad town, the community maintains its small-town heritage along a walkable Main Street corridor marked by the historic Melba Theater, the Arlington hotel, and local dining hubs like Pogolino's and Junction Cafe'. Housing is primarily characterized by quiet residential neighborhoods with single-family homes, garden-style apartment rentals, and waterfront retreats at Summerset Lake and Sunrise Lakes.
Outdoor access is a key perk, with Walthers Park in town and Washington State Park just 12 miles away for hiking and river outings. However, relocating nurses must account for practical tradeoffs: transit is virtually absent, and regional hospital shifts or major commercial errands require highway driving along U.S. Route 67 or Route 21. For nurses prioritizing a peaceful, low-noise community surrounded by rolling hills and close-knit neighbors, De Soto provides a restful retreat away from urban congestion.
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Neighborhoods
Residential options in De Soto range from the compact street grid near historic Main Street to rural acreage on the town's perimeter. Waterfront seekers often look to established private lake communities such as Summerset Lake and Sunrise Lakes, which feature lakefront residences and a vacation-like setting.
In-town neighborhoods around Jefferson Street, Rock Road, and North Second Street provide traditional single-family residential lots with immediate access to local schools and downtown shops.
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Housing
The housing landscape is predominantly composed of owner-occupied single-family homes, featuring established ranch-style houses, classic mid-century builds, and older historic residences on standard town lots. Renter options are concentrated in low-density, garden-style apartment complexes and scattered single-family homes for rent.
Buyers seeking scenic acreage or waterfront living often look toward outlying developments such as Sunrise Lakes and Summerset Lake.
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Getting around
De Soto is situated roughly 45 miles south of St. Louis, making personal vehicle ownership essential. Commuters heading north toward major hospital networks and specialized clinics in the greater St. Louis metropolitan area rely heavily on U.S. Route 67 and Missouri Route 21. Within the town's five-square-mile layout, surface street driving and parking are straightforward, but public transit is virtually nonexistent, meaning shift workers must plan for self-reliant highway driving.
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Food and dining
Dining in De Soto revolves around locally owned cafes, pizzerias, and casual roadhouse taverns rather than national chains. Longtime community favorites include Pogolino's on North Second Street and Imo's Pizza at Jefferson Square, alongside daytime staples like Junction Cafe' and Just Be Kind Cafe' on Main Street.
For hearty diner fare and barbecue, residents visit Granny Franny's Diner and Cafe' Smoke N Pi, while Mexican plates are served at El Lobo Rojo and Coyol Mexican Bar & Grill. Evening drinks and socializing often take place at Kozzys on Main, Fat Boy's Saloon & Grill, or nearby LaChance Vineyards.
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Outdoors
Outdoor recreation within town includes Walthers Park and local athletic fields, complemented by a historic rail caboose display on North Main Street. Just 12 miles outside the city, Washington State Park provides hiking trails, historic stone structures built by the Civilian Conservation Corps, and river access for swimming and paddling.
The area is also situated within reach of the broader Mark Twain National Forest region, with unique nearby attractions like disc golf at Crystal City Underground offering additional weekend diversions.
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Arts and culture
De Soto's cultural identity is rooted in its 19th-century railroad heritage and traditional community gatherings. The historic Main Street corridor features landmarks like the vintage Melba Theater and the historic Arlington hotel property.
Community life is anchored by seasonal parades, holiday festivals, and local school athletic events, while casual evening nightlife centers on spots like Fat Boy's Saloon & Grill and Starlite Drive-In Theatre in the surrounding area.
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Seasons and weather
De Soto experiences four distinct seasons characterized by temperate springs, humid summers, and crisp autumns. Winters bring periodic snowfall and cold snaps, though total seasonal snow accumulation remains modest.
Spring and early summer bring significant rainfall that keeps the surrounding Ozark borderlands lush, while fall provides clear weather and rich foliage across Jefferson County's rolling hills.
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For families
De Soto offers a family-oriented environment supported by local public schools such as Athena Elementary and Vineland Elementary, along with proximity to higher learning at Jefferson College roughly 10 miles away. Community youth gather around Walthers Park and neighborhood sports complexes.
While residents commend the town's safety and neighborly atmosphere, local feedback notes that older children and teens have limited indoor recreational venues within town lines, making trips to regional entertainment hubs necessary.
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What locals say
Residents describe De Soto as a tight-knit, peaceful former railroad town where neighbors look out for one another and community pride runs high. Reviewers frequently praise the quiet residential setting, low noise levels, and friendly small-town atmosphere.
The primary complaints focus on the lack of progressive amenities, limited local entertainment, and a shortage of dedicated recreational facilities or community centers for teens, requiring residents to drive to surrounding towns for major errands and leisure.