Skip to content

17 nursing jobs in Opelika, AL

Anchored by East Alabama Medical Center, Opelika pairs historic rail-town charm with a cost of living about 12% below the national average. Swap high-stress metro commutes for brick-lined downtown streets, craft breweries in repurposed cotton warehouses, and quiet evenings under live oaks—stretching your nursing paycheck further without sacrificing clinical depth.

Opelika, AL on the map· Open the live map
East Alabama Health workplace
East Alabama Health — a workplace named in a current Opelika postingView East Alabama Health →

Find a nursing job in Opelika

Hiring here: East Alabama Health (7) · Enhabit Home Health & Hospice (5) · East Alabama Medical Center (2) · Fresenius Medical Care (2)

East Alabama Health logo

East Alabama Health

Opelika, AL

  • New grads welcomed
  • RN
1 / 2

RN - AU EVENT Staff

East Alabama Medical Center

Opelika, AL

  • New grads welcomed
  • RN
  • ETS AU EVENTS
  • Per diem
1 / 3

RN - 5T Medical & POST Acute Stroke

East Alabama Health logoEast Alabama Health

Opelika, AL

  • RN

East Alabama Medical Center

Opelika, AL

  • LPN
  • Day shift
East Alabama Health workplace

East Alabama Health

4 open roles · Day · Permanent

  • RN
  • Day shift
  • RN
  • Day shift
  • ADN accepted

RN - 4T

Opelika, AL

  • RN
  • Day shift

RN - NSU

Opelika, AL

  • RN
  • ADN accepted

Healthcare employer

Opelika, AL

School Nurse

Posted 4 days ago

$49,000–$75,000/year

  • RN
East Alabama Health logo

East Alabama Health

Opelika, AL

  • RN
Enhabit Home Health & Hospice logo

Enhabit Home Health & Hospice

Opelika, AL

  • RN
  • Per diem
Fresenius Medical Care logo

Fresenius Medical Care

Opelika, AL

  • New grads welcomed · reported
  • RN
  • Floating required
Enhabit Home Health & Hospice logo

Enhabit Home Health & Hospice

Opelika, AL

  • RN
Fresenius Medical Care logo

Fresenius Medical Care

Opelika, AL

  • RN
  • Rotating shift
  • Floating required

Enhabit Home Health & Hospice

3 open roles · Per Diem · Hospice

Registered Nurse (RN) - Hospice - PRN

Opelika, AL · Posted last week

  • RN
  • Per diem

RN - Hospice

Opelika, AL · Posted last week

  • RN
  • RN
  • After Hours Hospice RN (Weekday Shift)
  • CEU allowance

Working and living in Opelika

· 17 open roles

Living costs

Metro price level
87.9 (100 = national)
BEA 2024
Median gross rent
$950/mo
Rent and tenant-paid utilities
Median household income
$65,004/yr
All local households, not nurse pay

Census ACS 2024

Open to new grads

3 postings explicitly welcome new grads.

Browse new grad roles

New to our board this week

2 current postings first appeared here in the past seven days.

Browse current openings

Credentials accepted

  • RN16
  • LPN1

One posting may accept more than one credential.

Shifts listed

  • Days4
  • per-diem4
  • Rotating1

Postings may list several shifts or leave the shift unspecified.

Living in Opelika

Opelika offers relocating nurses a refreshing blend of authentic Southern small-town charm and steady regional growth along the Interstate 85 corridor.

More about life here

Known as the sister city to college-dominated Auburn, Opelika stands apart with its historic railroad heritage, revitalized brick downtown, and distinct community character. Shift workers will appreciate predictable commutes averaging around seventeen minutes, allowing easy transit to regional medical facilities without the gridlock of larger metros.

Off-duty life thrives in the walkable downtown core, where local spots like Zazu Gastropub, Dough Pizzeria, and John Emerald Distilling Company offer genuine local dining and relaxation. For active recovery days, the 696-acre Chewacla State Park provides rugged mountain biking trails, waterfalls, and peaceful hiking, while nearby Auburn hosts major SEC sporting events and cultural performances at the Gogue Center.

Housing options span from character-filled historic homes near downtown to newer master-planned subdivisions off Gateway Drive. While Opelika lacks mass transit and relies on personal vehicles for daily life, nurses seeking a supportive community, accessible outdoor recreation, and a calmer pace will find it an ideal home base.

Sources
As of Sep 16, 2026
Neighborhoods

Prospective residents in Opelika generally look across a spectrum of historic, established, and newly built neighborhoods. The Downtown Opelika area attracts buyers and renters seeking historic homes, distinct architecture, mature trees, and walkable access to local boutiques and restaurants.

For commuters prioritizing interstate convenience, subdivisions located off Gateway Drive provide swift access to Interstate 85. The broader residential market includes established developments like Crestwood Acres, Royal Park Estates, and Lakeshore Estates, alongside newer suburban construction featuring modern layouts and community amenities.

Sources
Housing

Housing in Opelika ranges from early twentieth-century bungalows and historic architecture near downtown to spacious single-family subdivisions with generous yard sizes and mature tree canopies. Compared to neighboring Auburn, which has high concentrations of student-oriented housing, Opelika offers a more traditional residential mix of newer turnkey subdivisions, mid-century ranch homes, and master-planned communities.

Buyers and renters routinely view Opelika as an accessible value alternative within the metro area that provides larger lots and lower density.

Sources
Getting around

Opelika is situated along the Interstate 85 corridor, offering straightforward road connectivity between Montgomery and Atlanta. The average commute for local workers runs just over seventeen minutes, with minimal congestion compared to larger metropolitan areas.

Key arterial roads like Gateway Drive link directly into I-85 and connect Opelika with neighboring Auburn. Because public transportation is virtually nonexistent for daily work shifts, relying on a personal vehicle is essential for hospital commutes.

Sources
Food and dining

Opelika features a thriving dining core centered around its walkable downtown district, headlined by local favorites such as Zazu Gastropub and Dough Pizzeria. The craft beverage scene is anchored by John Emerald Distilling Company and Red Clay Brewing Company, both offering social tasting rooms with outdoor seating.

Outside the historic center, the sprawling Tiger Town commercial corridor provides a broad array of casual national and regional chain dining, while adjacent Auburn expands late-night options with venues like the Piccolo Jazz Bar.

Sources
Outdoors

Outdoor activity centers around Chewacla State Park, a 696-acre destination featuring a scenic lake, waterfall, swimming areas, and a renowned network of hiking and mountain biking trails. In neighboring Auburn, the Kreher Preserve & Nature Center offers quiet nature trails, educational programs, and a dedicated discovery forest playground.

Within Opelika and its immediate vicinity, green spaces like Town Creek Park provide manicured walking decks and picnic grounds for low-impact recreation throughout the year.

Sources
Arts and culture

Opelika embraces its railroad heritage through local landmarks like the Museum of East Alabama and the historic Salem-Shotwell Covered Bridge. Downtown Opelika regularly hosts community street festivals, farmers markets, and live performances, complemented by casual entertainment hubs like Rock 'N Roll Pinball.

Residents also enjoy easy access to major cultural institutions next door at Auburn University, including the Jay and Susie Gogue Performing Arts Center, the Jule Collins Smith Museum of Fine Art, and SEC game days at Jordan-Hare Stadium.

Sources
Seasons and weather

Opelika has a humid subtropical climate marked by long, hot, and humid summers where outdoor activity shifts toward mornings and water spots like Chewacla State Park. Winters are generally short and mild, with freezing temperatures occurring occasionally but significant snowfall remaining very rare.

Spring and autumn bring pleasant, moderate temperatures ideal for outdoor dining, community festivals, and college football season.

Sources
For families

Families in Opelika benefit from a close-knit community fabric served by the Opelika City Schools system and an active municipal parks and recreation department. Safe residential neighborhoods with cul-de-sacs and community amenities cater to raising children, alongside active recreation spots like Surge Adventure Park, the Kreher Preserve nature playground, and youth sports facilities.

While some families cross-shop Auburn for its top-tier public school ratings, Opelika is broadly recognized for offering good schools and a welcoming, family-friendly hometown environment.

Sources
What locals say

Locals praise Opelika for its friendly, down-to-earth atmosphere and vibrant historic downtown, often considering it a quieter, more grounded alternative to student-heavy Auburn. Residents value the sense of community, strong municipal parks and recreation programs, and consistent regional industrial job growth.

Tradeoffs mentioned in community forums include Auburn's higher-rated public schools, the occasional spillover traffic on university football game weekends, and a total reliance on personal vehicles for getting around.

Sources

Other cities