17 nursing jobs in Opelika, AL
Anchored by East Alabama Medical Center, Opelika pairs historic rail-town charm with a cost of living about 12% below the national average. Swap high-stress metro commutes for brick-lined downtown streets, craft breweries in repurposed cotton warehouses, and quiet evenings under live oaks—stretching your nursing paycheck further without sacrificing clinical depth.
Find a nursing job in Opelika
Hiring here: East Alabama Health (7) · Enhabit Home Health & Hospice (5) · East Alabama Medical Center (2) · Fresenius Medical Care (2)
RN - AU EVENT Staff
Opelika, AL
- New grads welcomed
- RN
- ETS AU EVENTS
- Per diem

East Alabama Health
4 open roles · Day · Permanent
East Alabama Health
4 open roles · Day · Permanent
RN - EAMC Emergency DEPT
Opelika, AL
- RN
- Day shift
RN II - Float POOL
Opelika, AL
- RN
- Day shift
- ADN accepted
RN - 4T
Opelika, AL
- RN
- Day shift
RN - NSU
Opelika, AL
- RN
- ADN accepted
Registered Nurse (RN) - Home Health - PRN
Posted 6 days ago
- RN
- Per diem
- New grads welcomed · reported
- RN
- Floating required
Enhabit Home Health & Hospice
3 open roles · Per Diem · Hospice
Enhabit Home Health & Hospice
3 open roles · Per Diem · Hospice
Registered Nurse (RN) - Hospice - PRN
Opelika, AL · Posted last week
- RN
- Per diem
RN - Hospice
Opelika, AL · Posted last week
- RN
After Hours Hospice RN (Weekday Shift)
Opelika, AL
- RN
- After Hours Hospice RN (Weekday Shift)
- CEU allowance
Working and living in Opelika
· 17 open roles
Living costs
- Median gross rent
- $950/mo
- Rent and tenant-paid utilities
- Median household income
- $65,004/yr
- All local households, not nurse pay
New to our board this week
2 current postings first appeared here in the past seven days.
Credentials accepted
- RN16
- LPN1
One posting may accept more than one credential.
Shifts listed
- Days4
- per-diem4
- Rotating1
Postings may list several shifts or leave the shift unspecified.
Living in Opelika
Opelika offers relocating nurses a refreshing blend of authentic Southern small-town charm and steady regional growth along the Interstate 85 corridor.
More about life hereShow less
Known as the sister city to college-dominated Auburn, Opelika stands apart with its historic railroad heritage, revitalized brick downtown, and distinct community character. Shift workers will appreciate predictable commutes averaging around seventeen minutes, allowing easy transit to regional medical facilities without the gridlock of larger metros.
Off-duty life thrives in the walkable downtown core, where local spots like Zazu Gastropub, Dough Pizzeria, and John Emerald Distilling Company offer genuine local dining and relaxation. For active recovery days, the 696-acre Chewacla State Park provides rugged mountain biking trails, waterfalls, and peaceful hiking, while nearby Auburn hosts major SEC sporting events and cultural performances at the Gogue Center.
Housing options span from character-filled historic homes near downtown to newer master-planned subdivisions off Gateway Drive. While Opelika lacks mass transit and relies on personal vehicles for daily life, nurses seeking a supportive community, accessible outdoor recreation, and a calmer pace will find it an ideal home base.
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Neighborhoods
Prospective residents in Opelika generally look across a spectrum of historic, established, and newly built neighborhoods. The Downtown Opelika area attracts buyers and renters seeking historic homes, distinct architecture, mature trees, and walkable access to local boutiques and restaurants.
For commuters prioritizing interstate convenience, subdivisions located off Gateway Drive provide swift access to Interstate 85. The broader residential market includes established developments like Crestwood Acres, Royal Park Estates, and Lakeshore Estates, alongside newer suburban construction featuring modern layouts and community amenities.
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Housing
Housing in Opelika ranges from early twentieth-century bungalows and historic architecture near downtown to spacious single-family subdivisions with generous yard sizes and mature tree canopies. Compared to neighboring Auburn, which has high concentrations of student-oriented housing, Opelika offers a more traditional residential mix of newer turnkey subdivisions, mid-century ranch homes, and master-planned communities.
Buyers and renters routinely view Opelika as an accessible value alternative within the metro area that provides larger lots and lower density.
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Getting around
Opelika is situated along the Interstate 85 corridor, offering straightforward road connectivity between Montgomery and Atlanta. The average commute for local workers runs just over seventeen minutes, with minimal congestion compared to larger metropolitan areas.
Key arterial roads like Gateway Drive link directly into I-85 and connect Opelika with neighboring Auburn. Because public transportation is virtually nonexistent for daily work shifts, relying on a personal vehicle is essential for hospital commutes.
Food and dining
Opelika features a thriving dining core centered around its walkable downtown district, headlined by local favorites such as Zazu Gastropub and Dough Pizzeria. The craft beverage scene is anchored by John Emerald Distilling Company and Red Clay Brewing Company, both offering social tasting rooms with outdoor seating.
Outside the historic center, the sprawling Tiger Town commercial corridor provides a broad array of casual national and regional chain dining, while adjacent Auburn expands late-night options with venues like the Piccolo Jazz Bar.
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Outdoors
Outdoor activity centers around Chewacla State Park, a 696-acre destination featuring a scenic lake, waterfall, swimming areas, and a renowned network of hiking and mountain biking trails. In neighboring Auburn, the Kreher Preserve & Nature Center offers quiet nature trails, educational programs, and a dedicated discovery forest playground.
Within Opelika and its immediate vicinity, green spaces like Town Creek Park provide manicured walking decks and picnic grounds for low-impact recreation throughout the year.
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Arts and culture
Opelika embraces its railroad heritage through local landmarks like the Museum of East Alabama and the historic Salem-Shotwell Covered Bridge. Downtown Opelika regularly hosts community street festivals, farmers markets, and live performances, complemented by casual entertainment hubs like Rock 'N Roll Pinball.
Residents also enjoy easy access to major cultural institutions next door at Auburn University, including the Jay and Susie Gogue Performing Arts Center, the Jule Collins Smith Museum of Fine Art, and SEC game days at Jordan-Hare Stadium.
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Seasons and weather
Opelika has a humid subtropical climate marked by long, hot, and humid summers where outdoor activity shifts toward mornings and water spots like Chewacla State Park. Winters are generally short and mild, with freezing temperatures occurring occasionally but significant snowfall remaining very rare.
Spring and autumn bring pleasant, moderate temperatures ideal for outdoor dining, community festivals, and college football season.
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For families
Families in Opelika benefit from a close-knit community fabric served by the Opelika City Schools system and an active municipal parks and recreation department. Safe residential neighborhoods with cul-de-sacs and community amenities cater to raising children, alongside active recreation spots like Surge Adventure Park, the Kreher Preserve nature playground, and youth sports facilities.
While some families cross-shop Auburn for its top-tier public school ratings, Opelika is broadly recognized for offering good schools and a welcoming, family-friendly hometown environment.
What locals say
Locals praise Opelika for its friendly, down-to-earth atmosphere and vibrant historic downtown, often considering it a quieter, more grounded alternative to student-heavy Auburn. Residents value the sense of community, strong municipal parks and recreation programs, and consistent regional industrial job growth.
Tradeoffs mentioned in community forums include Auburn's higher-rated public schools, the occasional spillover traffic on university football game weekends, and a total reliance on personal vehicles for getting around.