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Find a nursing job in Palmdale

Hiring here: UHS (17) · Palmdale Regional Medical Center (4) · ADMIRABLE HOME HEALTH SERVICES (1) · DAVITA (1) · Pacifica Infusion Services, LLC (1) · Yemaya Home Health LLC (1)

Pacifica Infusion Services, LLC logo

Pacifica Infusion Services, LLC

Palmdale, CA

Registered Nurse

$90,000–$300,000/year

  • RN

Yemaya Home Health LLC

Palmdale, CA

  • RN
  • Per diem
  • CEU allowance
Davita logo

Davita

Palmdale, CA

  • RN
  • Day shift
  • ADN accepted
UHS logo

UHS

Palmdale, CA · Health system employer

  • RN
Palmdale Regional Medical Center logo

Palmdale Regional Medical Center

Palmdale, CA

  • RN
  • Night shift
  • Per diem

Admirable Home Health Services

Palmdale, CA

  • RN
  • Per diem
UHS logo

UHS

PALMDALE, CA · Health system employer

  • RN
  • Per diem
Palmdale Regional Medical Center logo

Palmdale Regional Medical Center

Palmdale, CA

LPN/LVN

$29–$43/hr

  • LPN
  • Day shift
  • Floating required
UHS logo

UHS

PALMDALE, CA · Health system employer

Tech - ER

Posted yesterday

  • CNA
Palmdale Regional Medical Center logo

Palmdale Regional Medical Center

Palmdale, CA

  • LPN
  • Per diem
UHS logo

UHS

PALMDALE, CA · Health system employer

  • RN
  • Per diem
Palmdale Regional Medical Center logo

Palmdale Regional Medical Center

Palmdale, CA

  • LPN
  • Tuition reimbursement
  • Floating required

UHS

13 open roles

Registered Nurse (RN) - Med Surg Tele - Full Time

PALMDALE, CA · Posted 4 days ago

  • RN

Registered Nurse (RN) - Med Surg Tele - Full Time

PALMDALE, CA · Posted 4 days ago

  • RN

Charge Nurse - Emergency, Full Time, Night

PALMDALE, CA · Posted 5 days ago

  • RN

Case Manager RN-Per Diem Various

PALMDALE, CA · Posted 5 days ago

  • RN
  • Per diem

Registered Nurse (RN) - Med Surg Tele - Full Time

PALMDALE, CA · Posted 4 days ago

  • RN

Registered Nurse (RN) - Med Surg Tele - Full Time

PALMDALE, CA · Posted 4 days ago

  • RN

Charge Nurse ( RN), PACU

PALMDALE, CA · Posted 4 days ago

  • RN
  • CNA

Registered Nurse - PACU, Per Diem

Palmdale, CA · Posted 4 days ago

  • RN
  • Per diem

Case Manager RN-Per Diem Various

PALMDALE, CA · Posted 5 days ago

  • RN
  • Per diem

Registered Nurse - Surgery, Per Diem

Palmdale, CA · Posted 4 days ago

  • RN
  • Per diem

Registered Nurse - PACU, Full Time

Palmdale, CA · Posted 4 days ago

  • RN

Registered Nurse (RN) - Dialysis - Per Diem

Palmdale, CA · Posted last week

  • RN
  • Per diem

Working and living in Palmdale

· 25 open roles

Open to new grads

0 postings explicitly welcome new grads.

Browse new grad roles

New to our board this week

16 current postings first appeared here in the past seven days.

Browse current openings

Credentials accepted

  • RN20
  • LPN3
  • CNA2

One posting may accept more than one credential.

Shifts listed

  • Days2
  • per-diem2
  • Nights1

Postings may list several shifts or leave the shift unspecified.

Living in Palmdale

Palmdale offers healthcare professionals a distinct High Desert lifestyle defined by wide-open skies, aerospace heritage, and spacious suburban living that stands in stark contrast to the density of the Los Angeles basin.

More about life here

For nurses working locally in the Antelope Valley, daily commutes along surface streets and regional corridors like Highway 14 are straightforward, entirely avoiding the notorious commuter bottlenecks heading south toward Santa Clarita. Residential hubs such as Rancho Vista and nearby Quartz Hill provide sizable single-family homes with generous yards, quiet cul-de-sacs, and easy access to retail hubs near the Antelope Valley Mall.

Shift workers can decompress with unique outdoor escapes, from exploring the surreal geology of Vasquez Rocks and spring blooms at the Antelope Valley California Poppy Reserve to wandering past historic aircraft at Joe Davies Heritage Airpark. The essential tradeoff is adapting to high-desert climate extremes—blistering summer heat and biting winter winds—alongside an automobile-dependent layout with modest nightlife.

However, for nurses seeking space, predictable local routines, and mountain-framed vistas, Palmdale delivers practical, comfortable living.

Sources
As of Sep 16, 2026
Neighborhoods

Rancho Vista on the west side is one of the most prominent master-planned communities, popular for its newer single-family subdivisions, parks, and proximity to the Antelope Valley Mall. The Lakes and Palmdale West near Lake Elizabeth offer established mid-size homes and townhomes on larger parcels, while newer tracts like Vista Valencia and Liberty Ranch feature contemporary layouts and community parks.

Just across municipal lines, Quartz Hill and southwest Lancaster (Erwin Ranch) are frequent residential alternatives that offer quiet streets, larger lots, and manageable commutes.

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Housing

Housing stock is dominated by spacious post-1990s detached single-family homes in master-planned subdivisions, with townhomes and rental communities clustered primarily along major transit corridors like 10th Street West near the Antelope Valley Mall. Premium and higher-tier tracts are concentrated on the west side around Rancho Vista, Leona Valley, and adjacent Quartz Hill, whereas older neighborhoods in central Palmdale and outlying eastern enclaves offer more modest single-family homes and mid-century builds.

Sources
Getting around

Local driving across the Antelope Valley—including trips between Palmdale, Lancaster, and Littlerock—is generally light and predictable, avoiding major snarls. The primary friction point is State Route 14 (Antelope Valley Freeway), where severe rush-hour bottlenecks impact anyone traveling south toward Santa Clarita or Los Angeles.

For regional transit, the Antelope Valley Transit Authority (AVTA) operates local bus routes, while Metrolink commuter rail provides service south from Palmdale Station and nearby Vincent Grade/Acton directly to Los Angeles Union Station.

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Food and dining

Dining in Palmdale centers around casual suburban options, roadside staples, and prominent regional Mexican spots like El Toreo at 10th Street West and Elizabeth Lake Road. California fixtures like In-N-Out Burger are well-represented, and casual retail centers around 10th Street West and the Antelope Valley Mall host local spots alongside coffee options, such as the cafe inside Barnes & Noble.

Sources
Outdoors

Palmdale sits in the High Desert framed by Joshua trees and mountain vistas, offering trails for hiking, cycling, and equestrian use, as well as family recreation at Marie Kerr Park, Domenic Massari Park, and DryTown Water Park. Nearby regional destinations include the iconic rock formations at Vasquez Rocks Natural Area, the seasonal wildflower blooms at the Antelope Valley California Poppy Reserve, and scenic mountain escapes into the adjacent Angeles National Forest.

Sources
Arts and culture

Palmdale leans heavily into its identity as the 'Aerospace Capital of America,' showcasing historic military aviation at the Joe Davies Heritage Airpark and Blackbird Airpark, home to the iconic SR-71 reconnaissance aircraft adjacent to USAF Plant 42. Performing arts and community productions take the stage at the Palmdale Playhouse, while nearby day trips include farm-to-table stops in Quartz Hill and local wineries like Golden Star Vineyards in neighboring Littlerock.

Sources
Seasons and weather

Set in a high-desert basin, Palmdale experiences dramatic seasonal shifts and wide daily temperature swings. Summers are scorching and arid, driving residents indoors or to water amenities during the heat of the day.

Winters bring daytime temperatures in the 50s and 60s, dropping to freezing at night, paired with fierce high-desert winds that push wind chill values significantly lower and occasionally accompany dusting snow flurries. Spring remains breezy and transitional before summer conditions rapidly take hold.

Sources
What locals say

Residents appreciate Palmdale for its spacious floor plans, generous lot sizes, suburban order, and striking mountain backdrops compared to dense coastal Los Angeles. However, community members frequently highlight significant tradeoffs: high vehicle dependence, brutal summer desert heat, fierce winter wind chills, limited nightlife, and grueling traffic along Highway 14 for those commuting down into the Greater Los Angeles basin.

Sources

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