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42 nursing jobs in Prestonsburg, KY

Prestonsburg sits in the heart of eastern Kentucky's Appalachian foothills, offering small-town charm with nearby access to Jenny Wiley State Resort Park's trails and lake. Nurses who value close-knit communities, scenic mountain drives, and a slower pace of life will find this Floyd County seat a welcoming place to call home.

Prestonsburg, KY on the map· Open the live map

Find a nursing job in Prestonsburg

Hiring here: Appalachian Regional Healthcare (37) · Appalachian Regional Healthcare (ARH) (2) · Appalachian Regional Healthcare, Inc. (1) · Riverview Health Care Center (1) · TNAA Healthcare (1)

Riverview Health Care Center

Prestonsburg, KY

  • Sign-on bonus
  • RN
  • 7:00PM - 7:00AM
  • New grads welcomed
Appalachian Regional Healthcare logo

Appalachian Regional Healthcare

Prestonsburg, KY · Health system employer

  • RN/LPN/CNA

Appalachian Regional Healthcare, Inc.

Prestonsburg, KY

  • RN
  • ADN accepted
Appalachian Regional Healthcare (ARH) logo

Appalachian Regional Healthcare (ARH)

Prestonsburg, KY

  • RN
  • Orthopedic Clinic
  • ADN accepted
TNAA Healthcare logo

TNAA Healthcare

Prestonsburg, KY · Staffing partner

RN CathLab

$2,535/week

  • RN
  • Travel contract
Appalachian Regional Healthcare logo

Appalachian Regional Healthcare

Prestonsburg, KY · Health system employer

  • RN/LPN/CNA
Appalachian Regional Healthcare (ARH) logo

Appalachian Regional Healthcare (ARH)

Prestonsburg, KY

  • RN
  • ADN accepted

Appalachian Regional Healthcare

35 open roles · Per Diem · Permanent

Registered Nurse Tier 1

Prestonsburg, KY · Posted today

  • RN

Registered Nurse Tier 1

Prestonsburg, KY · Posted today

  • RN

Nurse Extern Tier II

Prestonsburg, KY · Posted today

  • RN/LPN/CNA

Registered Nurse

Prestonsburg, KY · Posted today

  • RN

Registered Nurse

Prestonsburg, KY · Posted today

  • RN

Nursing Assistant

Prestonsburg, KY · Posted today

  • CNA

Registered Nurse Tier 1

Prestonsburg, KY · Posted today

  • RN

Registered Nurse

Prestonsburg, KY · Posted today

  • RN

Nursing Assistant

Prestonsburg, KY · Posted today

  • CNA

Registered Nurse

Prestonsburg, KY · Posted today

  • RN

Registered Nurse

Prestonsburg, KY · Posted today

  • RN

Registered Nurse Tier 1

Prestonsburg, KY · Posted today

  • RN

Clinical Nurse Manager

Prestonsburg, KY · Posted today

  • CNM

Registered Nurse

Prestonsburg, KY · Posted today

  • RN

Registered Nurse

Prestonsburg, KY · Posted today

  • RN

Nurse Extern Tier II

Prestonsburg, KY · Posted today

  • RN/LPN/CNA

Registered Nurse

Prestonsburg, KY · Posted today

  • RN

Certified Nurse Aide Highlands

Prestonsburg, KY · Posted today

  • CNA

Registered Nurse

Prestonsburg, KY · Posted today

  • RN

Registered Nurse

Prestonsburg, KY · Posted today

  • RN

Registered Nurse Tier 1

Prestonsburg, KY · Posted today

  • RN

Clinical Nurse Manager

Prestonsburg, KY · Posted today

  • CNM

Registered Nurse Tier 1 Obstetrics

Prestonsburg, KY · Posted today

  • RN

Nurse Extern Tier II

Prestonsburg, KY · Posted today

  • RN/LPN/CNA

Registered Nurse

Prestonsburg, KY · Posted today

  • RN

Registered Nurse

Prestonsburg, KY · Posted today

  • RN

Registered Nurse

Prestonsburg, KY · Posted today

  • RN

Nurse Extern Tier II

Prestonsburg, KY · Posted today

  • RN/LPN/CNA

Nurse Extern Tier II

Prestonsburg, KY · Posted today

  • RN/LPN/CNA

Registered Nurse

Prestonsburg, KY · Posted today

  • RN

Registered Nurse

Prestonsburg, KY · Posted today

  • RN

Nurse Extern Tier II

Prestonsburg, KY · Posted today

  • RN/LPN/CNA

Registered Nurse Tier 1

Prestonsburg, KY · Posted today

  • RN

Registered Nurse

Prestonsburg, KY · Posted today

  • RN

Licensed Practical Nurse

Prestonsburg, KY

  • LPN

Working and living in Prestonsburg

· 42 open roles

Living costs

Median gross rent
$592/mo
Rent and tenant-paid utilities
Median household income
$25,746/yr
All local households, not nurse pay

Census ACS 2024

Open to new grads

1 postings explicitly welcome new grads.

Browse new grad roles

New to our board this week

36 current postings first appeared here in the past seven days.

Browse current openings

Credentials accepted

  • CNM2
  • RN36
  • LPN9
  • CNA11

One posting may accept more than one credential.

Shifts listed

  • Nights1
  • per-diem1

Postings may list several shifts or leave the shift unspecified.

Living in Prestonsburg

Nestled in the Appalachian foothills along Dewey Lake, Prestonsburg provides healthcare professionals with a quiet, scenic haven defined by mountain vistas and authentic Eastern Kentucky hospitality.

More about life here

Daily life moves at a relaxed tempo, centered around outdoor recreation at Jenny Wiley State Resort Park, biking along the Prestonsburg Passage from Archer Park, and evening shows at the Mountain Arts Center, home of the Kentucky Opry. The dining landscape embraces classic regional fare, featuring riverside comfort food at Billy Ray’s, barbecue at Pig in a Poke, and casual dinners at The Brickhouse.

However, relocating nurses must prepare for the seclusion inherent to rural mountain life. Public transit is practically nonexistent, meaning a reliable vehicle is essential for work commutes, hospital shifts, and everyday shopping.

While the town lacks metropolitan amenities and bustling nightlife, it compensates with an exceptionally peaceful, low-noise environment, strong community ties, and a grounded lifestyle where outdoor access is directly out your back door.

Sources
As of Sep 16, 2026
Neighborhoods

Prestonsburg is a small mountain community where residential life centers around quiet, low-density pockets such as North Highland Avenue, corridors along Old Route 114, and adjacent rural hamlets like Allen and Banner. The surrounding residential landscape is distinctly calm and spread-out, dominated by single-family homes and scenic mountain properties rather than defined urban neighborhoods.

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Housing

Housing in Prestonsburg consists predominantly of established single-family ranch homes, traditional detached houses on private lots, and small apartment complexes. Properties closer to downtown provide easier access to local services, while homes perched on hillsides or near Dewey Lake offer expansive mountain scenery and rural quietude.

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Getting around

Daily travel in Prestonsburg is overwhelmingly vehicle-dependent, as transit access is virtually nonexistent and everyday errands require driving. Commuting to local clinics or regional medical centers in neighboring hubs like Pikeville relies on mountain corridors such as Kentucky Route 114 and Route 1428, which generally experience low traffic congestion but require careful driving during winter freeze events.

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Food and dining

The local dining scene highlights comforting Appalachian flavors, anchored by Billy Ray's Restaurant serving homestyle Southern platters overlooking the river. Barbecue enthusiasts head to Pig in a Poke for smoked brisket and pulled pork, while The Brickhouse offers steaks, seafood, and craft cocktails; casual midday stops include Lizzie B's Cafe Bakery, City Perk Coffeehouse, and nostalgic smashburgers at Dairy Cheer.

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Outdoors

Recreational life revolves around Jenny Wiley State Resort Park and Dewey Lake, offering extensive boating, fishing, hiking trails, and post-adventure meals at Dewey's Bar & Grill. In town, Archer Park serves as a hub for pickleball and gives access to the paved Prestonsburg Passage trail, while mountain bikers and hikers explore the Sugar Camp Mountain Trails and StoneCrest Golf Course.

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Arts and culture

Regional culture is centered at the Mountain Arts Center (MAC), a premier performance hall that hosts touring concerts, theatrical productions, and the Kentucky Opry's country and bluegrass showcases. The town also features seasonal outdoor festivals in downtown Prestonsburg showcasing traditional Appalachian crafts and music, alongside community educational exhibits at the East Kentucky Science Center and Planetarium.

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Seasons and weather

Prestonsburg features a humid subtropical climate with four distinct seasons, beginning with lush, verdant springs and hot, humid summer months. Autumn brings crisp air and vibrant hillside foliage, while winter brings cooler temperatures and occasional snowfall that demands heightened caution on winding mountain roadways.

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For families

Families in Prestonsburg experience a relaxed, low-crime environment with active youth athletics and park amenities at Archer Park. Primary and secondary public education is managed within the local cluster, comprising Prestonsburg Elementary School, James D. Adams Middle School, and Prestonsburg High School, alongside vocational alternatives like the Carl D. Perkins Job Corporation Academy.

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What locals say

Residents praise Prestonsburg for its tranquil, low-noise environment, tight-knit mountain hospitality, and scenic natural surroundings along Dewey Lake. Conversely, community discussions highlight the drawbacks of rural seclusion, noting a developing local economic base, limited retail shopping, scarce nightlife, and total car reliance for basic errands.

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