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8 nursing jobs in Seguin, TX

Anchored by Guadalupe Regional Medical Center, Seguin swaps metropolitan gridlock for easy cross-town commutes. Settle into historic downtown Craftsman homes or Geronimo subdivisions, recharge along the Guadalupe River at Max Starcke Park, and grab acclaimed barbecue at Burnt Bean Co.—all with San Antonio under an hour away via Interstate 10.

Seguin, TX on the map· Open the live map
Guadalupe Regional Medical Center workplace
Guadalupe Regional Medical Center — a workplace named in a current Seguin postingView Guadalupe Regional Medical Center →

Find a nursing job in Seguin

Hiring here: Advanced Home Health Services (3) · Guadalupe Regional Medical Center (2) · Avir Health Group (1) · Avir at Seguin (1) · Right At Home (1)

Guadalupe Regional Medical Center logo

Guadalupe Regional Medical Center

Seguin, TX

  • RN
  • 7p-7a
  • ADN accepted
1 / 2

Registered Nurse (RN)

Avir at Seguin logoAvir at Seguin

Seguin, TX

  • New grads welcomed
  • RN
  • 12-⁠hour nights
1 / 4

Licensed Vocational Nurse- Day Shift

Avir Health Group logoAvir Health Group

Seguin, TX

  • New grads welcomed
  • LVN
  • 12-⁠hour days
Advanced Home Health Services logo

Advanced Home Health Services

Seguin, TX

  • RN/LVN
Guadalupe Regional Medical Center logo

Guadalupe Regional Medical Center

Seguin, TX

  • RN
  • Night shift
  • ADN accepted
Right At Home logo

Right At Home

Seguin, TX

  • Evenings shift
Advanced Home Health Services logo

Advanced Home Health Services

Seguin, TX

  • RN
Advanced Home Health Services logo

Advanced Home Health Services

Seguin, TX

  • RN

Working and living in Seguin

· 8 open roles

Living costs

Median gross rent
$1,187/mo
Rent and tenant-paid utilities
Median household income
$64,861/yr
All local households, not nurse pay

Census ACS 2024

Open to new grads

2 postings explicitly welcome new grads.

Browse new grad roles

New to our board this week

0 current postings first appeared here in the past seven days.

Browse current openings

Credentials accepted

  • RN6
  • LVN2

One posting may accept more than one credential.

Shifts listed

  • Nights3
  • Days1

Postings may list several shifts or leave the shift unspecified.

Living in Seguin

Seguin offers healthcare professionals a distinctive blend of historic Texas character, riverfront leisure, and small-city autonomy along the booming Interstate 10 corridor.

More about life here

Stationed at Guadalupe Regional Medical Center, nurses avoid exhausting metropolitan traffic while enjoying a tight-knit community anchored by the Guadalupe River and Max Starcke Park. The city center features vibrant independent dining—from nationally renowned barbecue at Burnt Bean Co. to patio brews at Pecantown Books & Brews—and community touchstones like Texas Lutheran University and Pecan Fest.

Housing caters to diverse preferences, offering historic Craftsman cottages near the downtown square, master-planned suburban construction in Geronimo, and waterfront properties on Lake Placid. The essential tradeoff is car dependence: with no local public transit, errands require driving, and specialized retail or major trauma centers require traveling thirty-five to fifty-five minutes west into San Antonio or north toward New Braunfels.

For nurses seeking clinical autonomy, manageable daily commutes, and authentic Central Texas pace, Seguin provides a grounded and welcoming home base.

Sources
As of Sep 16, 2026
Neighborhoods

Nurses moving to Seguin can choose between distinct pockets across Guadalupe County. Downtown Seguin offers historic Victorian and Craftsman homes within walking distance of the courthouse square and the Guadalupe River greenway.

Newer master-planned subdivisions with larger square footage are concentrated around Geronimo and the North Seguin corridor along State Highway 46, both providing straightforward access to Interstate 10. Waterfront neighborhoods cluster along Lake Placid and Lake McQueeney, while the Kingsbury area provides rural acreage and quiet country settings for those wanting space away from town center.

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Housing

Residential options in Seguin span character-rich historic bungalows and Victorian homes downtown to newly developed single-family subdivisions in Geronimo and north along State Highway 46. Apartment communities such as Walnut Grove provide modern multifamily living close to campus and retail corridors. Properties directly fronting Lake Placid and the Guadalupe River command a premium, though buyers should evaluate floodplain boundaries along the river before purchasing.

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Getting around

Clinical staff working locally at Guadalupe Regional Medical Center enjoy short, hassle-free drives across town, but a reliable personal vehicle is essential since Seguin does not operate a municipal public transit system. For those splitting shifts or commuting toward San Antonio along Interstate 10, expect roughly a thirty-five to fifty-five-minute drive to reach central employment hubs and the South Texas Medical Center.

Connections northwest toward New Braunfels rely heavily on State Highway 46.

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Food and dining

Seguin's dining scene is anchored downtown by Burnt Bean Co., an acclaimed barbecue destination that draws statewide attention, along with casual patio stops like 1916 Bar & Bistro at the historic Aumont and Pecantown Books & Brews. Along the Guadalupe River, The Powerplant Texas Bar & Grill serves homestyle fare overlooking Saffold Dam.

Other local gathering spots include A-Tan Asian Bistro & Sushi Bar with patios facing Walnut Springs Park, Seguin Brewing Company, and rural tasting rooms such as Windmill Farm Winery and Blue Lotus Winery.

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Outdoors

Outdoor recreation revolves around the Guadalupe River corridor, where locals fish, kayak, and tube during warmer months. Max Starcke Park serves as the central outdoor hub with its riverside walking trails, tennis courts, and municipal golf course along the water.

Nearby reservoirs including Lake Placid and Lake McQueeney cater to boating and watersports, while Walnut Springs Park offers an urban greenway path running through the heart of town.

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Arts and culture

Community identity is tied to deep Texas heritage, epitomized by the World's Largest Pecan statue on the courthouse square and the annual Pecan Fest Heritage Days celebration. Cultural programming includes live productions at The Palace Theatre, exhibitions by the Seguin Art League, and campus lectures and music recitals at Texas Lutheran University.

Historic landmarks such as the Sebastopol House Historic Site and Heritage Village preserve early architectural roots.

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Seasons and weather

Seguin has a humid subtropical climate defined by long, intensely hot summers where daytime temperatures frequently push into the upper nineties, sending residents toward the shade and cooling currents of the Guadalupe River. Autumn and spring deliver mild, comfortable weather ideal for patio dining, park trails, and open-air festivals.

Winters remain generally brief and gentle with infrequent freezing snaps.

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For families

Families are served by Seguin Independent School District as well as Navarro Independent School District to the north, both managing facility expansions to accommodate population growth. Max Starcke Park offers extensive playgrounds, sports courts, and green spaces, while ZDT's Amusement Park provides year-round family entertainment with water coasters and go-karts.

Established neighborhoods near schools in East Seguin and newer suburban subdivisions offer peaceful residential pockets.

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What locals say

Residents appreciate Seguin's genuine small-city warmth, vibrant riverfront parks, and self-contained amenities that allow daily life to function without relying on San Antonio trips. The community values its historic town square and flourishing local culinary scene.

However, locals frequently point out that rapid population growth and new subdivisions have outpaced roadway infrastructure, public transit remains nonexistent, and specialized retail or high-tier entertainment often requires driving out toward New Braunfels or San Antonio.

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