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61 nursing jobs in Poplar Bluff, MO

Poplar Bluff sits in southeastern Missouri's Ozark foothills, offering small-town calm with easy access to outdoor recreation. Nurses relocating here will find a tight-knit community, a slower pace of life, and a regional healthcare hub serving surrounding rural areas.

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Helia Healthcare workplace
Helia Healthcare — a workplace named in a current Poplar Bluff postingView Helia Healthcare →

Find a nursing job in Poplar Bluff

Hiring here: POPLAR BLUFF RMC & RHC (27) · Veterans Health Administration (15) · Poplar Bluff Regional Medical Center (7) · Avani Healthcare (2) · AMEDISYS HOME HEALTH (1) · BBH Burrell Behavioral Health (1)

Helia Healthcare

Poplar Bluff, MO

  • LPN
1 / 2

Director of Nursing (DON)

Cedargate Health Care Center

Poplar Bluff, MO

$95,000–$100,000/year

  • RN
  • Per diem
1 / 2

Med/Surg Medical RN Nights

Poplar Bluff Regional Medical Center logoPoplar Bluff Regional Medical Center

Poplar Bluff, MO

  • Sign-on bonus
  • RN
  • Night shift
  • Compact license OK
1 / 2

Registered Nurse

Westwood HILLS Health and Rehab Center

Poplar Bluff, MO

$38–$50/hr

  • RN
  • Day shift
  • CEU allowance
Poplar Bluff Regional Medical Center workplace

Poplar Bluff Regional Medical Center

6 open roles · rotating & 12 hour shifts · Permanent

Rehab RN

Poplar Bluff, MO · Posted last week

  • Sign-on bonus
  • RN

ER RN Day

Poplar Bluff, MO · Posted 6 days ago

  • RN

ER RN Evening

Poplar Bluff, MO · Posted last week

  • Sign-on bonus
  • RN

Same Day Surgical RN

Poplar Bluff, MO · Posted last week

  • RN
  • Rotating shift
  • Compact license OK

Rehab RN

Poplar Bluff, MO

  • New grads welcomed
  • RN
  • Rotating shift
  • Compact license OK
  • Sign-on bonus
  • RN
  • 12-⁠hour 12 hour
  • Tuition reimbursement

Veterans Health Administration

Poplar Bluff, MO · Health system employer

  • RN
  • 8-⁠hour days
  • Compact license OK
Avani Healthcare logo

Avani Healthcare

Poplar Bluff, MO

RN - Med Surg

Posted last week

$63/hr

  • RN
  • Travel contract
Amedisys Home Health logo

Amedisys Home Health

Poplar Bluff, MO

Registered Nurse

$70,000/year

  • Sign-on bonus
  • RN
  • Day shift

Poplar BLUFF RMC & RHC

Poplar Bluff, MO

Med/Surg LPN 5th Floor

Posted yesterday

  • LPN
Burrell Behavioral Health logo

Burrell Behavioral Health

Poplar Bluff, MO

Licensed Practical Nurse

Posted last week

  • LPN
State of Missouri logo

State of Missouri

Poplar Bluff, MO

  • LPN
  • Rotating shift
  • Compact license OK
HealthTrust Workforce Solutions logo

HealthTrust Workforce Solutions

Poplar Bluff, MO

  • RN
  • Travel contract

BBH Burrell Behavioral Health

Poplar Bluff, MO

Licensed Practical Nurse

Posted last week

  • LPN

Healthcare employer

Poplar Bluff, MO

LPN/RN

Posted last week

  • RN/LPN

Veterans Health Administration

Poplar Bluff, MO

  • RN
Avani Healthcare logo

Avani Healthcare

Poplar Bluff, MO

Med Surg RN

$2,196–$2,276/week

  • RN
  • 12-⁠hour nights
  • Travel contract

Poplar BLUFF RMC & RHC

Poplar Bluff, MO

Med Surg RN Nights

Posted yesterday

  • Sign-on bonus
  • RN

Veterans Health Administration

Poplar Bluff, MO · Health system employer

  • New grads welcomed
  • RN
  • 8-⁠hour days
  • Compact license OK

Poplar BLUFF RMC & RHC

Poplar Bluff, MO

Rehab RN

Posted yesterday

  • RN

Veterans Health Administration

Poplar Bluff, MO · Health system employer

Registered Nurse - Specialty Care Float

Closing date passed

$65,000–$130,000/year

  • New grads welcomed
  • RN
  • Monday - Friday, 8:00am - 4:30pm
  • Compact license OK

Poplar BLUFF RMC & RHC

Poplar Bluff, MO

ER RN Evening

Posted last week

  • Sign-on bonus
  • RN

Veterans Health Administration

Poplar Bluff, MO · Health system employer

  • New grads welcomed
  • RN
  • Monday - Friday, 8:00am - 4:30pm
  • Specialty Care Services

Poplar BLUFF RMC & RHC

Poplar Bluff, MO

Same Day Surgical RN

Posted yesterday

  • RN

Veterans Health Administration

Poplar Bluff, MO · Health system employer

  • New grads welcomed
  • RN
  • Monday, Tuesday, Thursday, Friday, 7:00am - 5:30pm
  • Compact license OK

Poplar BLUFF RMC & RHC

Poplar Bluff, MO

  • Sign-on bonus
  • RN

Veterans Health Administration

Poplar Bluff, MO · Health system employer

  • RN
  • 8-⁠hour days
  • Compact license OK

Poplar BLUFF RMC & RHC

Poplar Bluff, MO

  • RN

Veterans Health Administration

Poplar Bluff, MO · Health system employer

  • RN
  • Monday - Friday, 8:00am - 4:30pm
  • Compact license OK

Poplar BLUFF RMC & RHC

Poplar Bluff, MO

Same Day Surgical RN

Posted yesterday

  • RN

Veterans Health Administration

Poplar Bluff, MO · Health system employer

  • RN
  • Day shift
  • ADN accepted

Poplar BLUFF RMC & RHC

Poplar Bluff, MO

Rehab RN PRN Night

Posted yesterday

  • RN
  • Per diem

Veterans Health Administration

Poplar Bluff, MO · Health system employer

  • New grads welcomed
  • RN
  • 6:00 p.m. to 6:30 a.m., including rotating weekend shifts.
  • Compact license OK

Poplar BLUFF RMC & RHC

Poplar Bluff, MO

Veterans Health Administration

Poplar Bluff, MO · Health system employer

Registered Nurse - Acute Care

$65,000–$130,000/year

  • RN
  • Night shift
  • ADN accepted

Poplar BLUFF RMC & RHC

Poplar Bluff, MO

PCU RN Days

Posted 4 days ago

  • RN

Veterans Health Administration

Poplar Bluff, MO · Health system employer

  • New grads welcomed
  • RN
  • Day shift

Poplar BLUFF RMC & RHC

Poplar Bluff, MO

ER RN Charge

Posted last week

  • RN

Veterans Health Administration

Poplar Bluff, MO · Health system employer

  • RN
  • Day shift
  • ADN accepted

Poplar BLUFF RMC & RHC

Poplar Bluff, MO

RN Mother/Baby FT Nights

Posted 4 days ago

  • RN

Veterans Health Administration

Poplar Bluff, MO · Health system employer

  • New grads welcomed
  • APRN

Poplar BLUFF RMC & RHC

Poplar Bluff, MO

RN- Float Pool Days

Posted yesterday

  • RN

Veterans Health Administration

Poplar Bluff, MO · Health system employer

  • LPN/LVN
  • Rotating shift

Veterans Health Administration

Poplar Bluff, MO · Health system employer

  • RN

Working and living in Poplar Bluff

· 61 open roles

Living costs

Median gross rent
$760/mo
Rent and tenant-paid utilities
Median household income
$41,941/yr
All local households, not nurse pay

Census ACS 2024

Open to new grads

9 postings explicitly welcome new grads.

Browse new grad roles

New to our board this week

31 current postings first appeared here in the past seven days.

Browse current openings

Credentials accepted

  • APRN1
  • RN53
  • LPN7
  • LVN1

One posting may accept more than one credential.

Shifts listed

  • Days12
  • Nights4
  • Rotating4
  • per-diem2

Postings may list several shifts or leave the shift unspecified.

Living in Poplar Bluff

Known as the Gateway to the Ozarks, Poplar Bluff serves as the commercial and healthcare anchor for Southeast Missouri.

More about life here

For relocating healthcare professionals, the city offers an unhurried, rooted lifestyle where short commutes—typically around eleven minutes—replace congested metropolitan transit. Daily life is centered along the Black River, with residential pockets spanning quiet subdivisions like Windwood Drive and Cedar Valley Drive to established corridors near Gardner Street.

Outside work, nurses can unwind at local spots like La Torcia Brick Oven Pizza or Myrtle’s Place, catch live performances at the Historic Rodgers Theatre, or tour exhibits at the Margaret Harwell Art Museum. Outdoor recreation is the town's premier calling card, featuring local walks along Shelby Trail and McLane Park, alongside weekend access to Lake Wappapello State Park, Keener Springs, and the Eleven Point River.

Relocators must weigh distinct trade-offs: Poplar Bluff is entirely car-dependent with practically non-existent public transit, nightlife remains modest, and regional economic disparities exist. However, for nurses seeking genuine community warmth, peaceful neighborhoods, and premier access to Missouri's southern waterways, Poplar Bluff delivers a grounded and accessible home base.

Sources
As of Sep 16, 2026
Neighborhoods

Poplar Bluff's residential layout spans established central neighborhoods and quieter subdivisions on the city's perimeter. Areas around Cedar Valley Drive feature single-story ranch homes with open yards, while pockets along Windwood Drive and Gardner Street provide established residential streets and a sizable rental presence.

Outlying corridors along Highway M transition into more rural settings with generous acreage. Commuting from nearly any residential enclave across town to regional medical centers takes minimal drive time over low-congestion city thoroughfares.

Sources
Housing

Housing stock in Poplar Bluff is primarily composed of traditional single-family single-story ranches, historic bungalows, and rural builds on sprawling parcels. Neighborhoods like Cedar Valley Drive highlight modern detached homes with attached garages, while multifamily options and rental properties are concentrated along corridors such as Gardner Street.

The housing market offers accessible homeownership opportunities and flexible rental inventory without the bidding wars found in larger Missouri metros.

Sources
Getting around

Getting to work in Poplar Bluff is almost entirely car-dependent, but drive times are exceptionally short, with typical local commutes averaging around eleven minutes. Primary thoroughfares like Highway M and local connectors link directly into healthcare facilities with effortless hospital parking and minimal traffic slowdowns.

Public transit options are virtually nonexistent, and the town lacks dedicated cycling corridors, making personal vehicles indispensable for medical shifts.

Sources
Food and dining

Dining in Poplar Bluff centers around casual local staples, family eateries, and regional roadside favorites. Residents frequent spots like La Torcia Brick Oven Pizza for casual Italian fare and Myrtle's Place for local community meals, alongside familiar national casual and drive-thru chains along the main commercial corridors.

Local coffee shops cater to morning routines, while late-night food options are primarily limited to 24-hour fast food near the highways.

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Outdoors

Set directly on the Black River and promoted as the Gateway to the Ozarks, Poplar Bluff offers substantial outdoor access. Within town, residents walk the Shelby Trail and make use of McLane Park, Kiwanis Bacon Park, and Ferguson Grove Park.

A short drive unlocks major regional recreation, including boating and camping at Lake Wappapello State Park and Clearwater Lake, cold-water floating along the Eleven Point River, natural swimming at Keener Springs, and hiking ancient granite formations at Elephant Rocks State Park.

Sources
Arts and culture

Cultural life reflects the town's historical roots in timber and rail transportation. Arts and history hubs include the Margaret Harwell Art Museum, housed in an 1883 estate displaying regional artists, the Mo-Ark Regional Railroad Museum in the historic depot, and the Poplar Bluff Museum.

Live entertainment congregates downtown at the restored Historic Rodgers Theatre, on stage at Three Rivers College's Tinnin Fine Arts Center, and at the Black River Coliseum, which hosts regional sports tournaments, expos, and arena concerts.

Sources
Seasons and weather

Poplar Bluff experiences four distinct seasons characterized by a humid subtropical climate. Summers are hot and humid, peaking in July with afternoon temperatures regularly climbing into the nineties, making river recreation essential.

Winters are relatively mild, with January bringing periodic freezing nights and occasional light snowfall averaging around five inches annually. Spring brings frequent rain showers, with May recording the wettest stretch, while early autumn produces comfortable, crisp conditions with drier days through September and October.

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For families

Families in Poplar Bluff find a low-noise, small-city atmosphere supported by community parks like McLane Park and Ferguson Grove Park, alongside family recreation venues like Skate City. Higher education and performing arts programming are anchored locally by Three Rivers College.

While long-term residents foster a stable, neighborhood-centric environment, incoming families should note that educational resources and specialty pediatric care may require navigating the wider Butler County footprint.

Sources
What locals say

Locals cherish Poplar Bluff as a welcoming, tight-knit community where neighbors wave and shop owners recognize regulars, appreciating the calm pace and lack of metro congestion. Outdoors enthusiasts celebrate its quick access to Ozark rivers, lakes, and forested bluffs.

Conversely, community discussions frequently note the reality of limited transit, visible poverty in parts of town, and a quieter commercial scene, with some residents debating whether larger regional hubs like Cape Girardeau offer more variety.

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