61 nursing jobs in Poplar Bluff, MO
Poplar Bluff sits in southeastern Missouri's Ozark foothills, offering small-town calm with easy access to outdoor recreation. Nurses relocating here will find a tight-knit community, a slower pace of life, and a regional healthcare hub serving surrounding rural areas.
Find a nursing job in Poplar Bluff
Hiring here: POPLAR BLUFF RMC & RHC (27) · Veterans Health Administration (15) · Poplar Bluff Regional Medical Center (7) · Avani Healthcare (2) · AMEDISYS HOME HEALTH (1) · BBH Burrell Behavioral Health (1)
- RN
- Per diem
Med/Surg Medical RN Nights
Poplar Bluff, MO
- Sign-on bonus
- RN
- Night shift
- Compact license OK
- RN
- Day shift
- CEU allowance

Poplar Bluff Regional Medical Center
6 open roles · rotating & 12 hour shifts · Permanent
Poplar Bluff Regional Medical Center
6 open roles · rotating & 12 hour shifts · Permanent
Rehab RN
Poplar Bluff, MO · Posted last week
- Sign-on bonus
- RN
ER RN Day
Poplar Bluff, MO · Posted 6 days ago
- RN
ER RN Evening
Poplar Bluff, MO · Posted last week
- Sign-on bonus
- RN
Same Day Surgical RN
Poplar Bluff, MO · Posted last week
- RN
- Rotating shift
- Compact license OK
Rehab RN
Poplar Bluff, MO
- New grads welcomed
- RN
- Rotating shift
- Compact license OK
Registered Nurse FOR ELIGIBLE RN POSITIONS
Poplar Bluff, MO
- Sign-on bonus
- RN
- 12-hour 12 hour
- Tuition reimbursement
Registered Nurse - Community Living Center (CLC) - Resident Assessment Coordinator
$65,000–$130,000/year
- RN
- 8-hour days
- Compact license OK
- LPN
- Rotating shift
- Compact license OK
- RN
- Travel contract
Registered Nurse - Quality Nurse Consultant (Patient Safety Manager)
$65,000–$130,000/year
- RN
Registered Nurse - Community Living Center (CLC) - Resident Assessment Coordinator
$65,000–$130,000/year
- New grads welcomed
- RN
- 8-hour days
- Compact license OK
- New grads welcomed
- RN
- Monday - Friday, 8:00am - 4:30pm
- Compact license OK
Registered Nurse - Specialty Care Outpatient
$65,000–$130,000/year
- New grads welcomed
- RN
- Monday - Friday, 8:00am - 4:30pm
- Specialty Care Services
Registered Nurse - Behavioral Health Interdisciplinary Program (BHIP) Float
$65,000–$130,000/year
- New grads welcomed
- RN
- Monday, Tuesday, Thursday, Friday, 7:00am - 5:30pm
- Compact license OK
Med/Surg 6th Floor RN- FT nights
Posted 4 days ago
- Sign-on bonus
- RN
Registered Nurse (Nurse Manager Specialty Care Services)
$121,000–$160,000/year
- RN
- 8-hour days
- Compact license OK
Registered Nurse - (Sterile Processing Service Chief)
$74,000–$131,000/year
- RN
- Monday - Friday, 8:00am - 4:30pm
- Compact license OK
Registered Nurse - Nursing Officer of the Day
$77,000–$135,000/year
- RN
- Day shift
- ADN accepted
Registered Nurse - Community Living Center
$65,000–$130,000/year
- New grads welcomed
- RN
- 6:00 p.m. to 6:30 a.m., including rotating weekend shifts.
- Compact license OK
Lead Patient Care Tech - 7:30am-4pm M-F
Closing date passed
Registered Nurse - Acute Care
$65,000–$130,000/year
- RN
- Night shift
- ADN accepted
Psychiatric Advanced Practice Registered Nurse - Mental Health
$115,000–$168,000/year
- New grads welcomed
- RN
- Day shift
Registered Nurse - Primary Care Mental Health Integration
$65,000–$130,000/year
- RN
- Day shift
- ADN accepted
Advanced Practice Registered Nurse - Compensation and Pension
$115,000–$168,000/year
- New grads welcomed
- APRN
Practical Nurse (Community Living Center)
$45,000–$82,000/year
- LPN/LVN
- Rotating shift
Registered Nurse - Quality Management Nurse Consultant (Accreditation)
$65,000–$130,000/year
- RN
Working and living in Poplar Bluff
· 61 open roles
Living costs
- Median gross rent
- $760/mo
- Rent and tenant-paid utilities
- Median household income
- $41,941/yr
- All local households, not nurse pay
New to our board this week
31 current postings first appeared here in the past seven days.
Credentials accepted
- APRN1
- RN53
- LPN7
- LVN1
One posting may accept more than one credential.
Shifts listed
- Days12
- Nights4
- Rotating4
- per-diem2
Postings may list several shifts or leave the shift unspecified.
Living in Poplar Bluff
Known as the Gateway to the Ozarks, Poplar Bluff serves as the commercial and healthcare anchor for Southeast Missouri.
More about life hereShow less
For relocating healthcare professionals, the city offers an unhurried, rooted lifestyle where short commutes—typically around eleven minutes—replace congested metropolitan transit. Daily life is centered along the Black River, with residential pockets spanning quiet subdivisions like Windwood Drive and Cedar Valley Drive to established corridors near Gardner Street.
Outside work, nurses can unwind at local spots like La Torcia Brick Oven Pizza or Myrtle’s Place, catch live performances at the Historic Rodgers Theatre, or tour exhibits at the Margaret Harwell Art Museum. Outdoor recreation is the town's premier calling card, featuring local walks along Shelby Trail and McLane Park, alongside weekend access to Lake Wappapello State Park, Keener Springs, and the Eleven Point River.
Relocators must weigh distinct trade-offs: Poplar Bluff is entirely car-dependent with practically non-existent public transit, nightlife remains modest, and regional economic disparities exist. However, for nurses seeking genuine community warmth, peaceful neighborhoods, and premier access to Missouri's southern waterways, Poplar Bluff delivers a grounded and accessible home base.
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Neighborhoods
Poplar Bluff's residential layout spans established central neighborhoods and quieter subdivisions on the city's perimeter. Areas around Cedar Valley Drive feature single-story ranch homes with open yards, while pockets along Windwood Drive and Gardner Street provide established residential streets and a sizable rental presence.
Outlying corridors along Highway M transition into more rural settings with generous acreage. Commuting from nearly any residential enclave across town to regional medical centers takes minimal drive time over low-congestion city thoroughfares.
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Housing
Housing stock in Poplar Bluff is primarily composed of traditional single-family single-story ranches, historic bungalows, and rural builds on sprawling parcels. Neighborhoods like Cedar Valley Drive highlight modern detached homes with attached garages, while multifamily options and rental properties are concentrated along corridors such as Gardner Street.
The housing market offers accessible homeownership opportunities and flexible rental inventory without the bidding wars found in larger Missouri metros.
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Getting around
Getting to work in Poplar Bluff is almost entirely car-dependent, but drive times are exceptionally short, with typical local commutes averaging around eleven minutes. Primary thoroughfares like Highway M and local connectors link directly into healthcare facilities with effortless hospital parking and minimal traffic slowdowns.
Public transit options are virtually nonexistent, and the town lacks dedicated cycling corridors, making personal vehicles indispensable for medical shifts.
Food and dining
Dining in Poplar Bluff centers around casual local staples, family eateries, and regional roadside favorites. Residents frequent spots like La Torcia Brick Oven Pizza for casual Italian fare and Myrtle's Place for local community meals, alongside familiar national casual and drive-thru chains along the main commercial corridors.
Local coffee shops cater to morning routines, while late-night food options are primarily limited to 24-hour fast food near the highways.
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Outdoors
Set directly on the Black River and promoted as the Gateway to the Ozarks, Poplar Bluff offers substantial outdoor access. Within town, residents walk the Shelby Trail and make use of McLane Park, Kiwanis Bacon Park, and Ferguson Grove Park.
A short drive unlocks major regional recreation, including boating and camping at Lake Wappapello State Park and Clearwater Lake, cold-water floating along the Eleven Point River, natural swimming at Keener Springs, and hiking ancient granite formations at Elephant Rocks State Park.
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Arts and culture
Cultural life reflects the town's historical roots in timber and rail transportation. Arts and history hubs include the Margaret Harwell Art Museum, housed in an 1883 estate displaying regional artists, the Mo-Ark Regional Railroad Museum in the historic depot, and the Poplar Bluff Museum.
Live entertainment congregates downtown at the restored Historic Rodgers Theatre, on stage at Three Rivers College's Tinnin Fine Arts Center, and at the Black River Coliseum, which hosts regional sports tournaments, expos, and arena concerts.
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Seasons and weather
Poplar Bluff experiences four distinct seasons characterized by a humid subtropical climate. Summers are hot and humid, peaking in July with afternoon temperatures regularly climbing into the nineties, making river recreation essential.
Winters are relatively mild, with January bringing periodic freezing nights and occasional light snowfall averaging around five inches annually. Spring brings frequent rain showers, with May recording the wettest stretch, while early autumn produces comfortable, crisp conditions with drier days through September and October.
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For families
Families in Poplar Bluff find a low-noise, small-city atmosphere supported by community parks like McLane Park and Ferguson Grove Park, alongside family recreation venues like Skate City. Higher education and performing arts programming are anchored locally by Three Rivers College.
While long-term residents foster a stable, neighborhood-centric environment, incoming families should note that educational resources and specialty pediatric care may require navigating the wider Butler County footprint.
What locals say
Locals cherish Poplar Bluff as a welcoming, tight-knit community where neighbors wave and shop owners recognize regulars, appreciating the calm pace and lack of metro congestion. Outdoors enthusiasts celebrate its quick access to Ozark rivers, lakes, and forested bluffs.
Conversely, community discussions frequently note the reality of limited transit, visible poverty in parts of town, and a quieter commercial scene, with some residents debating whether larger regional hubs like Cape Girardeau offer more variety.
