79 nursing jobs in Little River, SC
Little River is a laid-back coastal fishing village on South Carolina's Intracoastal Waterway, just south of the North Carolina line and minutes from North Myrtle Beach. Expect saltwater marinas, seafood festivals, and a slower pace of life for nurses seeking a quieter waterfront base.
Find a nursing job in Little River
Hiring here: McLeod Health (77) · Encompass Health (1) · Tidelands Health Rehabilitation Hospital, an affiliate of Encompass Health (1)
Dialysis RN
$35–$50/hr
- RN
- Per diem
McLeod Health
45 open roles
McLeod Health
45 open roles
Cardiology APP Opportunity | McLeod Seacoast & Carolina Forest
Little River, SC · Posted today
- New grads welcomed
- NP
- Day shift
Pain Management APP (NP/PA) – Outpatient Orthopedic Practice
Little River, SC · Posted last week
- NP
- Day shift
Case Manager Weekend (Part-Time Weekends) - Seacoast
Little River, SC · Posted last week
- RN
- Weekend shift
Staff Nurse - Medical Intensive Care Unit (MICU)
Little River, SC · Posted 3 days ago
- RN
Surgical Services Educator Operating Room-(FT)-Seacoast
Little River, SC · Posted last week
- RN
CRNA- McLeod Seacoast Hospital (Little River, SC)
Little River, SC · Posted last week
- New grads welcomed
- CRNA
- Day shift
Staff Nurse - WOW v2 - Medical Intensive Care Unit (MICU)
Little River, SC · Posted 3 days ago
- RN
Nurse Extern - Medical Surgical
Little River, SC · Posted 3 days ago
- RN
Coastal CRNA PRN - MLSH CRNA
Little River, SC · Posted last week
- New grads welcomed
- CRNA
- Per diem
Breast Surgery & Breast Health- Physician Assistant / Nurse Practitioner
Little River, SC · Posted last week
- New grads welcomed
- NP
- Day shift
McLeod Orthopedics- Ortho NOW APP (Physician Assistant/ Nurse Practitioner)
Little River, SC · Posted last week
- New grads welcomed
- NP
- Rotating shift
Staff Nurse - WOW v2 - Medical Intensive Care Unit (MICU)
Little River, SC · Posted 4 days ago
- RN
Staff Nurse - Medical Intensive Care Unit (MICU)
Little River, SC · Posted 4 days ago
- RN
Staff Nurse (FT) Medical Intensive Care Unit (MICU)
Little River, SC · Posted 6 days ago
- RN
Staff Nurse - WOW v2 - Surgical 2
Little River, SC · Posted last week
- RN
Staff Nurse (PRN) Emergency Services
Little River, SC · Posted last week
- RN
- Per diem
Nurse Extern - Medical Surgical
Little River, SC · Posted last week
- RN
Staff Nurse (PRN) Cardiovascular Lab
Little River, SC · Posted last week
- RN
- Per diem
Occupational Health Nurse - Clinic (PRN, As Needed)
Little River, SC · Posted last week
- RN
- Per diem
Staff Nurse (FT) Medical
Little River, SC · Posted last week
- RN
Staff Nurse - Medical Surgical - Nightshift - 7pm-7am - Monday-Thursday with an occasional weekend.
Little River, SC · Posted last week
- RN
- Night shift
Nurse Extern (PRN)Medical Surgical
Little River, SC · Posted last week
- RN
- Per diem
Registered Nurse (PRN) Endoscopy Lab Seacoast
Little River, SC · Posted last week
- RN
- Per diem
Registered Nurse - Medical Surgical - Nightshift 7pm-7am, Monday-Thursday with occasional weekend relief
Little River, SC · Posted last week
- RN
- Night shift
Nurse Extern - Medical Intensive Care Unit (MICU)
Little River, SC · Posted last week
- RN
Staff Nurse (FT) Medical Surgical - Nightshift - 7pm-7am - Monday-Thursday with occasional weekend
Little River, SC · Posted last week
- RN
- Night shift
Staff Nurse (FT) Observation
Little River, SC · Posted last week
- RN
Staff Nurse (PRN)Nursing Administration Seacoast
Little River, SC · Posted 2 weeks ago
- RN
- Per diem
Staff Nurse (FT) Medical Surgical - Nightshift 7pm-7am, Mostly Monday-Thursday with occassional weekend.
Little River, SC · Posted last week
- RN
- Night shift
Wound And Ostomy Care Nurse (PRN) Nursing Administration
Little River, SC · Posted last week
- RN
- Per diem
Licensed Practical Nurse - McLeod Urology Seacoast - FT
Little River, SC · Posted last week
- LPN
Registered Nurse (PRN) Surgical 2 Seacoast
Little River, SC · Posted last week
- RN
- Per diem
Registered Nurse Radiology (As Needed) - Seacoast
Little River, SC · Posted last week
- RN
Staff Nurse -(FT) Emergency Services 7p-7a
Little River, SC · Posted last week
- RN
- Night shift
Staff Nurse - Hemodialysis - Dialysis
Little River, SC · Posted last week
- RN
Physician Office - LPN - McLeod Primary Care Seacoast PBC - FT
Little River, SC · Posted last week
- LPN
Staff Nurse (PRN) Medical
Little River, SC · Posted last week
- RN
- Per diem
Staff Nurse (PRN) Emergency Services
Little River, SC · Posted last week
- RN
- Per diem
RN Case Manager (PRN) - Seacoast
Little River, SC · Posted last week
- RN
- Per diem
Staff Nurse (FT) Emergency Services
Little River, SC · Posted last week
- RN
Nurse Extern - Medical Surgical
Little River, SC · Posted last week
- RN
Staff Nurse (FT) M-TH Rotating Progressive Transitional Care Unit (PTCU)
Little River, SC · Posted last week
- RN
- Rotating shift
Nurse Extern - Medical Surgical
Little River, SC · Posted last week
- RN
Licensed Practical Nurse - Urology Seacoast - FT
Little River, SC · Posted last week
- LPN
Medical Surgical Technician (PRN) Nursing Administration Seacoast
Little River, SC · Posted last week
- CNA
- Per diem
Working and living in Little River
· 79 open roles
Living costs
- Median gross rent
- $1,528/mo
- Rent and tenant-paid utilities
- Median household income
- $65,786/yr
- All local households, not nurse pay
New to our board this week
10 current postings first appeared here in the past seven days.
Credentials accepted
- CRNA2
- NP4
- RN69
- LPN3
- CNA1
One posting may accept more than one credential.
Shifts listed
- per-diem28
- Nights9
- Days7
- Rotating2
- Evenings1
- weekend1
Postings may list several shifts or leave the shift unspecified.
Living in Little River
Little River offers relocating healthcare professionals a serene coastal retreat grounded in maritime heritage at the northern border of South Carolina.
More about life hereShow less
Unlike the bustling tourism strips of central Myrtle Beach, this historic fishing village on the Intracoastal Waterway retains a calmer tempo under canopies of ancient live oaks. Housing options include planned developments like Bridgewater, townhomes in Heather Glen, and quiet waterfront retreats near scenic marshland.
Outdoor life is defined by deep-sea expeditions with the Little River Fishing Fleet, kayaking through quiet backwaters, and hiking the wooden boardwalks of Vereen Memorial Gardens. Community identity shines during the annual Blue Crab Festival and Little River ShrimpFest along the waterfront docks.
For nurses, the primary tradeoffs involve navigating traffic along Highway 17 and managing travel times to regional medical centers as rapid growth challenges local road and clinical infrastructure. For those seeking coastal living without high-rise chaos, Little River provides an authentic Carolina coastal base.
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Neighborhoods
Residential life in Little River centers on master-planned communities and golf enclaves like Bridgewater, Heather Glen, and Serenity Point, alongside older properties positioned near the Intracoastal Waterway. Compared to resort towns further south, the area offers a sleepier residential character with single-family houses and townhomes, though newer developments continue to add suburban density along the Highway 17 corridor.
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Housing
The local housing market features a blend of coastal cottages, modern subdivisions such as Bridgewater, townhome developments in Heather Glen, and golf-oriented single-family housing. Little River serves as a moderately priced residential alternative to oceanfront areas like Cherry Grove or North Myrtle Beach, although inland options in Longs or Loris remain more economical.
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Getting around
Commuting from Little River relies almost entirely on private vehicles navigating Highway 17, the primary north-south artery connecting the town to medical facilities in North Myrtle Beach, Myrtle Beach, and Brunswick County. Increasing population growth along the northern Grand Strand has intensified peak-hour traffic delays, making shift commute times dependent on seasonal tourist surges and local road congestion.
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Food and dining
Dining revolves around fresh local seafood along the waterfront docks and the Intracoastal Waterway, where historic fishing fleets bring in daily catches. The community offers casual dockside taverns, riverfront spots, and convenient access to Calabash-style seafood venues directly across the North Carolina state line.
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Outdoors
Outdoor recreation focuses on the Intracoastal Waterway and surrounding marshes, featuring guided paddling tours with J & L Kayaks, deep-sea fishing through the Little River Fishing Fleet, and inshore outings with Captain Smiley's. On land, Vereen Memorial Gardens provides boardwalks and nature trails through salt marshes and live oaks, while golf enthusiasts frequent River Hills Golf Club and Eagle Nest Golf Club.
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Arts and culture
Little River's cultural scene is anchored by signature annual community events celebrating regional coastal tradition, notably the Blue Crab Festival and the Little River ShrimpFest along the historic waterfront. Other leisure attractions include evening waterway sails on Cruisin' Tikis and offshore gambling cruises operated aboard the Big 'M' Casino yacht.
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For families
Families are zoned into the Horry County Schools district, with parents evaluating school choices across the broader northern county system. While neighborhoods like Bridgewater offer peaceful, family-friendly surroundings, larger family hubs with extensive master-planned park networks and top-tier school clusters like Carolina Forest lie further inland and south.
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What locals say
Residents praise Little River for its unhurried rhythm, ancient live oaks, and authentic maritime charm, appreciating that it lacks the high-rise tourist congestion of Myrtle Beach. Conversely, community forums voice frustration over rapid suburban sprawl eroding the quiet town character, growing traffic burdens, and concerns over the strain on local healthcare capacity and medical care access.