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79 nursing jobs in Little River, SC

Little River is a laid-back coastal fishing village on South Carolina's Intracoastal Waterway, just south of the North Carolina line and minutes from North Myrtle Beach. Expect saltwater marinas, seafood festivals, and a slower pace of life for nurses seeking a quieter waterfront base.

Little River, SC on the map· Open the live map
Tidelands Health Rehabilitation Hospital, an affiliate of Encompass Health workplace
Tidelands Health Rehabilitation Hospital, an affiliate of Encompass Health — a workplace named in a current Little River postingView Tidelands Health Rehabilitation Hospital, an affiliate of Encompass Health →

Find a nursing job in Little River

Hiring here: McLeod Health (77) · Encompass Health (1) · Tidelands Health Rehabilitation Hospital, an affiliate of Encompass Health (1)

Tidelands Health Rehabilitation Hospital, an affiliate of Encompass Health logo

Tidelands Health Rehabilitation Hospital, an affiliate of Encompass Health

Little River, SC

Dialysis RN

$35–$50/hr

  • RN
  • Per diem
McLeod Health logo

McLeod Health

Little River, SC

  • RN
  • Compact license OK
Encompass Health logo

Encompass Health

Little River, SC

  • RN
  • Tuition reimbursement

McLeod Health

45 open roles

  • New grads welcomed
  • NP
  • Day shift
  • NP
  • Day shift

Case Manager Weekend (Part-Time Weekends) - Seacoast

Little River, SC · Posted last week

  • RN
  • Weekend shift

Staff Nurse - Medical Intensive Care Unit (MICU)

Little River, SC · Posted 3 days ago

  • RN
  • RN

CRNA- McLeod Seacoast Hospital (Little River, SC)

Little River, SC · Posted last week

  • New grads welcomed
  • CRNA
  • Day shift
  • RN

Nurse Extern - Medical Surgical

Little River, SC · Posted 3 days ago

  • RN

Coastal CRNA PRN - MLSH CRNA

Little River, SC · Posted last week

  • New grads welcomed
  • CRNA
  • Per diem
  • New grads welcomed
  • NP
  • Day shift
  • New grads welcomed
  • NP
  • Rotating shift
  • RN

Staff Nurse - Medical Intensive Care Unit (MICU)

Little River, SC · Posted 4 days ago

  • RN

Staff Nurse (FT) Medical Intensive Care Unit (MICU)

Little River, SC · Posted 6 days ago

  • RN

Staff Nurse - WOW v2 - Surgical 2

Little River, SC · Posted last week

  • RN

Staff Nurse (PRN) Emergency Services

Little River, SC · Posted last week

  • RN
  • Per diem

Nurse Extern - Medical Surgical

Little River, SC · Posted last week

  • RN

Staff Nurse (PRN) Cardiovascular Lab

Little River, SC · Posted last week

  • RN
  • Per diem

Occupational Health Nurse - Clinic (PRN, As Needed)

Little River, SC · Posted last week

  • RN
  • Per diem

Staff Nurse (FT) Medical

Little River, SC · Posted last week

  • RN

Nurse Extern (PRN)Medical Surgical

Little River, SC · Posted last week

  • RN
  • Per diem

Registered Nurse (PRN) Endoscopy Lab Seacoast

Little River, SC · Posted last week

  • RN
  • Per diem

Nurse Extern - Medical Intensive Care Unit (MICU)

Little River, SC · Posted last week

  • RN

Staff Nurse (FT) Observation

Little River, SC · Posted last week

  • RN

Staff Nurse (PRN)Nursing Administration Seacoast

Little River, SC · Posted 2 weeks ago

  • RN
  • Per diem
  • RN
  • Per diem
  • LPN

Registered Nurse (PRN) Surgical 2 Seacoast

Little River, SC · Posted last week

  • RN
  • Per diem

Registered Nurse Radiology (As Needed) - Seacoast

Little River, SC · Posted last week

  • RN

Staff Nurse -(FT) Emergency Services 7p-7a

Little River, SC · Posted last week

  • RN
  • Night shift

Staff Nurse - Hemodialysis - Dialysis

Little River, SC · Posted last week

  • RN

Staff Nurse (PRN) Medical

Little River, SC · Posted last week

  • RN
  • Per diem

Staff Nurse (PRN) Emergency Services

Little River, SC · Posted last week

  • RN
  • Per diem

RN Case Manager (PRN) - Seacoast

Little River, SC · Posted last week

  • RN
  • Per diem

Staff Nurse (FT) Emergency Services

Little River, SC · Posted last week

  • RN

Nurse Extern - Medical Surgical

Little River, SC · Posted last week

  • RN
  • RN
  • Rotating shift

Nurse Extern - Medical Surgical

Little River, SC · Posted last week

  • RN

Licensed Practical Nurse - Urology Seacoast - FT

Little River, SC · Posted last week

  • LPN
  • CNA
  • Per diem

Working and living in Little River

· 79 open roles

Living costs

Median gross rent
$1,528/mo
Rent and tenant-paid utilities
Median household income
$65,786/yr
All local households, not nurse pay

Census ACS 2024

Open to new grads

5 postings explicitly welcome new grads.

Browse new grad roles

New to our board this week

10 current postings first appeared here in the past seven days.

Browse current openings

Credentials accepted

  • CRNA2
  • NP4
  • RN69
  • LPN3
  • CNA1

One posting may accept more than one credential.

Shifts listed

  • per-diem28
  • Nights9
  • Days7
  • Rotating2
  • Evenings1
  • weekend1

Postings may list several shifts or leave the shift unspecified.

Living in Little River

Little River offers relocating healthcare professionals a serene coastal retreat grounded in maritime heritage at the northern border of South Carolina.

More about life here

Unlike the bustling tourism strips of central Myrtle Beach, this historic fishing village on the Intracoastal Waterway retains a calmer tempo under canopies of ancient live oaks. Housing options include planned developments like Bridgewater, townhomes in Heather Glen, and quiet waterfront retreats near scenic marshland.

Outdoor life is defined by deep-sea expeditions with the Little River Fishing Fleet, kayaking through quiet backwaters, and hiking the wooden boardwalks of Vereen Memorial Gardens. Community identity shines during the annual Blue Crab Festival and Little River ShrimpFest along the waterfront docks.

For nurses, the primary tradeoffs involve navigating traffic along Highway 17 and managing travel times to regional medical centers as rapid growth challenges local road and clinical infrastructure. For those seeking coastal living without high-rise chaos, Little River provides an authentic Carolina coastal base.

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As of Sep 16, 2026
Neighborhoods

Residential life in Little River centers on master-planned communities and golf enclaves like Bridgewater, Heather Glen, and Serenity Point, alongside older properties positioned near the Intracoastal Waterway. Compared to resort towns further south, the area offers a sleepier residential character with single-family houses and townhomes, though newer developments continue to add suburban density along the Highway 17 corridor.

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Housing

The local housing market features a blend of coastal cottages, modern subdivisions such as Bridgewater, townhome developments in Heather Glen, and golf-oriented single-family housing. Little River serves as a moderately priced residential alternative to oceanfront areas like Cherry Grove or North Myrtle Beach, although inland options in Longs or Loris remain more economical.

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Getting around

Commuting from Little River relies almost entirely on private vehicles navigating Highway 17, the primary north-south artery connecting the town to medical facilities in North Myrtle Beach, Myrtle Beach, and Brunswick County. Increasing population growth along the northern Grand Strand has intensified peak-hour traffic delays, making shift commute times dependent on seasonal tourist surges and local road congestion.

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Food and dining

Dining revolves around fresh local seafood along the waterfront docks and the Intracoastal Waterway, where historic fishing fleets bring in daily catches. The community offers casual dockside taverns, riverfront spots, and convenient access to Calabash-style seafood venues directly across the North Carolina state line.

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Outdoors

Outdoor recreation focuses on the Intracoastal Waterway and surrounding marshes, featuring guided paddling tours with J & L Kayaks, deep-sea fishing through the Little River Fishing Fleet, and inshore outings with Captain Smiley's. On land, Vereen Memorial Gardens provides boardwalks and nature trails through salt marshes and live oaks, while golf enthusiasts frequent River Hills Golf Club and Eagle Nest Golf Club.

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Arts and culture

Little River's cultural scene is anchored by signature annual community events celebrating regional coastal tradition, notably the Blue Crab Festival and the Little River ShrimpFest along the historic waterfront. Other leisure attractions include evening waterway sails on Cruisin' Tikis and offshore gambling cruises operated aboard the Big 'M' Casino yacht.

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For families

Families are zoned into the Horry County Schools district, with parents evaluating school choices across the broader northern county system. While neighborhoods like Bridgewater offer peaceful, family-friendly surroundings, larger family hubs with extensive master-planned park networks and top-tier school clusters like Carolina Forest lie further inland and south.

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What locals say

Residents praise Little River for its unhurried rhythm, ancient live oaks, and authentic maritime charm, appreciating that it lacks the high-rise tourist congestion of Myrtle Beach. Conversely, community forums voice frustration over rapid suburban sprawl eroding the quiet town character, growing traffic burdens, and concerns over the strain on local healthcare capacity and medical care access.

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