92 nursing jobs in Seneca, SC
Nestled between Lake Keowee and Lake Hartwell, Seneca trades metropolitan hospital hustle for Blue Ridge foothill calm. Decompress paddleboarding at South Cove County Park or enjoying Jazz in the Alley on historic Ram Cat Alley. Commuting along US-123, nurses choose between early twentieth-century downtown bungalows and resort-style waterfront retreats in gated Keowee Key.
Find a nursing job in Seneca
Hiring here: 110 Prisma Health-Upstate (62) · Prisma Health (17) · 121 Prisma Health-University Medical Group (4) · ATC Healthcare Services of Georgia (2) · American Traveler (2) · CenterWell Senior Primary Care (1)

Prisma Health
17 open roles
Prisma Health
17 open roles
- RN
- Rotating shift
- Per diem
- RN
- Night shift
- RN
- Rotating shift
- Per diem
- LPN
- Day shift
- Per diem
- RN
- Night shift
- RN
- Night shift
- RN
- Rotating shift
- RN
- Night shift
- LPN
- Night shift
- hospice inpatient unit
- LPN
- Day shift
- RN
- Rotating shift
- Per diem
- RN
- Rotating shift
- RN
- Day shift
- The Family Birthplace
- New grads welcomed
- LPN
- Day shift
- Per diem
- New grads welcomed
- LPN
- Day shift
- Per diem
- RN
- Night shift
- Per diem
- RN
- Night shift
- Per diem
Patient Observation Director - Seneca, SC
$70,000–$75,000/year
- RN
- Per diem
- New grads welcomed
- LPN
- RN
- Travel contract
- RN
- 12-hour nights
- Travel contract
Registered Nurse (RN) - LD Labor & Delivery
Up to $2,114/week
- RN
- 12-hour nights
- Travel contract
- LPN
- Residency program
Licensed Practical Nurse (LPN) - Ambulatory Care, Oconee Urology, FT
Posted 2 days ago
- New grads welcomed
- LPN
- RN
- Travel contract
Registered Nurse (RN) - MedSurg / Tele
Up to $1,195/week
- RN
- 12-hour days
- Travel contract
- RN
- Residency program
Physician Assistant / Nurse Practitioner - Orthopedics - Seneca
Posted 2 days ago
- NP
- RN
Physician Assistant / Nurse Practitioner - General Surgery - Seneca
Posted 2 days ago
- NP
110 Prisma Health-Upstate
14 open roles
110 Prisma Health-Upstate
14 open roles
Registered Nurse (RN) - Acute Care, Facility Resource Pool, Oconee, PT, Night
Seneca, SC · Posted 2 days ago
- RN
Registered Nurse (RN) - Asst Nurse Manager, Surgical Specialty, Full Time, Night
Seneca, SC · Posted 2 days ago
- RN
Registered Nurse (RN)- Nurse Resident, Winter 2027, Medical/Surgical Unit
Seneca, SC · Posted 2 days ago
- RN
- Residency program
Registered Nurse (RN) - Acute Care, Med/Surg, Full Time, Variable
Seneca, SC · Posted 2 days ago
- RN
Licensed Practical Nurse (LPN)- Ambulatory, Seneca Medical Associates, FT, Day
Seneca, SC · Posted 2 days ago
- New grads welcomed
- LPN
Nursing Asst.,Cert., (Cottingham Hospice House), PRN, Days
Seneca, SC · Posted 2 days ago
- CNA
- Per diem
Registered Nurse (RN) - Acute Care, Med/Surg, Full-Time, Night
Seneca, SC · Posted 2 days ago
- RN
Certified Nursing Assistant, Cottingham Hospice House, PRN, Days
Seneca, SC · Posted last week
- CNA
- Per diem
Nursing Assistant
Seneca, SC · Posted last week
Registered Nurse (RN)-Hospice Inpatient, PT, Nights
Seneca, SC · Posted 5 days ago
- New grads welcomed
- RN
Registered Nurse (RN) - Acute Care, Surgical Specialty, Full Time, Night
Seneca, SC · Posted 2 days ago
- RN
Registered Nurse (RN) - Nurse Resident, December 2026, Surgical Specialty
Seneca, SC · Posted 2 days ago
- RN
- Residency program
Nursing Assistant Cert
Seneca, SC · Posted 2 days ago
- New grads welcomed
- CNA
Certified Nursing Assistant, Cardiac Telemetry, Part-Time, Nights
Seneca, SC · Posted 2 days ago
- CNA
Working and living in Seneca
· 92 open roles
Living costs
- Median gross rent
- $807/mo
- Rent and tenant-paid utilities
- Median household income
- $52,022/yr
- All local households, not nurse pay
New to our board this week
66 current postings first appeared here in the past seven days.
Credentials accepted
- NP3
- RN60
- LPN13
- CNA12
One posting may accept more than one credential.
Shifts listed
- Nights9
- Days7
- Rotating5
- per-diem1
Postings may list several shifts or leave the shift unspecified.
Living in Seneca
Seneca offers relocating healthcare professionals an exceptional balance of calm, lakeside living and Blue Ridge foothill recreation.
More about life hereShow less
Positioned squarely between the pristine waters of Lake Keowee and Lake Hartwell, the city allows nurses to unwind on paddleboards at South Cove County Park, explore nearby waterfalls in the Jocassee Gorges, or enjoy post-shift strolls through Ram Cat Alley. This historic downtown core serves as Seneca's communal living room, hosting craft breweries, local bistros, and events like Jazz in the Alley.
Housing accommodates diverse lifestyle goals, offering early twentieth-century bungalows near town, suburban yards, and gated waterfront enclaves like Keowee Key. Commutes along US-123 and SC-28 are straightforward, though car dependency is essential and Clemson University home game weekends can choke regional roadways.
Relocating nurses should also prepare for intense summer humidity and heavy spring pollen. For clinicians seeking relief from frenetic metropolitan hospitals in favor of a welcoming, tight-knit town where outdoor adventure begins right at the driveway, Seneca proves an inviting Upstate destination.
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Neighborhoods
Residential options in Seneca range from established downtown streets lined with early twentieth-century bungalows and midcentury homes to expansive waterfront communities along Lake Keowee and Lake Hartwell. Private gated subdivisions such as Keowee Key offer resort-style amenities, private golf, and lake access, attracting retirees and professionals seeking a quiet retreat.
Closer to the core, historic neighborhoods surrounding Ram Cat Alley provide walkable charm and quick access to local shops, while traditional subdivisions sit situated along the outer corridors toward Clemson and Walhalla.
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Housing
Seneca's housing landscape provides diverse choices, ranging from historic bungalows and midcentury single-family ranch homes in central Oconee County to modern planned subdivisions with spacious yards. The highest-tier market is defined by Lake Keowee waterfront estates, private dock properties, and master-planned gated golf communities like Keowee Key.
More affordable alternatives sit inland and in established neighborhoods near town, where buyers face a balanced market with room for standard inspection contingencies.
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Getting around
Seneca is predominantly car-dependent, with daily travel centered around major regional corridors including US-123, SC-28, and US-76. Driving between Seneca and nearby medical facilities or university hubs in Clemson is typically direct along US-123, though regional traffic increases substantially on Clemson University football game days and during typical morning and evening commute windows. While neighboring Clemson operates the Clemson Area Transit bus system, transit coverage does not broadly serve Seneca neighborhoods, making a reliable personal vehicle necessary for hospital shift work.
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Food and dining
Dining in Seneca centers around the historic Ram Cat Alley pedestrian district, which hosts an eclectic mix of independent bistros, local farm-to-table eateries, Italian spots, and barbecue joints. The downtown area also features neighborhood craft breweries and casual pubs, while standard regional chains and quick-service diners cluster along the US-123 commercial strip.
Shift workers seeking late-night dining or high-end culinary variety often head into nearby Clemson or take day trips toward Greenville.
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Outdoors
Outdoor recreation is Seneca's premier calling card, set directly between the clear waters of Lake Keowee and the vast expanse of Lake Hartwell. South Cove County Park sits just minutes from downtown, offering public boat ramps, lakefront campsites, beaches, and tennis courts, while High Falls County Park provides lakeside swimming and recreation areas.
Residents have rapid access to whitewater rafting on the wild Chattooga River, boating and tours on Lake Jocassee, and hiking trails connecting dozens of Blue Ridge foothills waterfalls and Table Rock State Park.
Arts and culture
Local culture blends historic railroad heritage with an active regional arts community. Ram Cat Alley serves as the community social anchor, hosting recurring public events like Jazz in the Alley, Cruizin' on Main car shows, and the annual Seneca Fest.
Cultural institutions include the Lunney House Museum, the Bertha Lee Strickland Cultural Museum, and rotating regional exhibits at the Blue Ridge Arts Center, while major collegiate athletics and performing arts programming are easily accessible minutes away at Clemson University.
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Seasons and weather
Seneca enjoys a four-season climate nestled in the Upstate foothills, though summers can be demanding with prolonged heat, heavy humidity, and frequent afternoon thunderstorms. Spring arrives early with blooming dogwoods and azaleas, accompanied by a heavy blanket of yellow pine pollen that coats vehicles and outdoor decks.
Autumn brings crisp mountain air and striking fall foliage across the nearby Blue Ridge escarpment, while winters remain generally mild with occasional frosty snaps and rare light snow.
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For families
Seneca provides a quiet, family-oriented environment supported by Oconee County public schools and a strong network of civic and faith-based community spaces. Waterfront county parks such as South Cove and High Falls offer dedicated playgrounds, picnic shelters, and sports courts that serve as regular weekend gathering spots.
The smaller-town scale fosters an active neighborhood feel, though parents often utilize nearby Clemson for specialized enrichment activities and youth sporting events.
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What locals say
Residents consistently praise Seneca for its friendly, laid-back atmosphere, safety, and effortless access to lakes and mountain scenery. However, locals and newcomers note clear tradeoffs: commercial shopping, entertainment, and nightlife are modest compared to Greenville or larger metropolitan areas, requiring an hour drive for specialty services.
Practical complaints frequently center on heavy spring pollen, summer humidity, regional pest management considerations like termites, and the lack of comprehensive public transit.