509 nursing jobs in Greenville, SC
Set against the Blue Ridge foothills, Greenville pairs a booming Upstate healthcare hub with an enviable outdoor rhythm. Trade hospital shifts for evening runs along the Swamp Rabbit Trail or dinners overlooking Falls Park on the Reedy. Best of all, living costs sit about 7% below the national average, giving your RN salary real breathing room.
Also hiring: Greenville, NC (58) · Greenville, OH (17) · Greenville, TX (16) · Greenville, MS (8)
Find a nursing job in Greenville
Hiring here: 110 Prisma Health-Upstate (256) · Prisma Health (109) · 121 Prisma Health-University Medical Group (59) · Bon Secours (11) · Bon Secours Mercy Health (10) · 170 Prisma Health (9)
Director of Nursing Services/RN- Mecklenburg Health & Rehab
Greenville, SC
- Sign-on bonus
- RN
- Compact license OK
Nurse Practitioner / Physicians Assistant - Acute Care - PRN
Greenville, SC
- NP
- Per diem
- Sign-on bonus
- RN
- 12-hour nights
- +$5/hr differential
- Sign-on bonus
- RN
- New grads welcomed
- LPN
- 8-hour shifts
- Per diem
Registered Nurse (RN) - Acute Care, General Medicine, FT, Night
Posted last week
- RN
- Night (United States of America)
- General Medicine Unit
- RN
- Day shift
- Sign-on bonus
- RN
- New grads welcomed
Occupational Health Nurse - 1026
$62,000–$87,000/year
- RN
- Employee Health Center
Nurse Practitioner - PPV
Posted last week
- NP
- Night shift
Registered Nurse (RN) - Med Surg Unit - St. Francis Downtown
Posted yesterday
- RN
- NP
- Rotating shift
- Per diem
- New grads welcomed
- LPN
- Day (United States of America)
- Compact license OK
Registered Nurse Home Health
Posted last week
- RN
- Tuition reimbursement
- RN
- 12-hour nights
- Travel contract
Certified Nursing Assistant, Cardiac Telemetry, Full Time, Days
Posted 3 days ago
- New grads welcomed
- CNA
- Day shift
Registered Nurse (RN) - Inpatient Surgery - St. Francis Eastside
Posted yesterday
- RN
- 12-hour days
Health Clinic Assistant Administrator - 1026
$86,000–$121,000/year
- NP/RN
- Rotating shift
- Employee Health Center
Home Health On-Call Registered Nurse
Posted 4 days ago
- RN
Registered Nurse (RN) - Cardiovascular Intensive Care Unit (CVICU) - St. Francis Downtown
Posted yesterday
- Sign-on bonus
- RN
- Night shift
Anesthetist - Greenville Memorial
Posted today
- CRNA
- Rotating shift
Registered Nurse (RN) - Program Coordinator Sepsis, FT, Days
Posted last week
- RN
- Day (United States of America)
- Compact license OK
- RN
- Day shift
Registered Nurse (RN) - Emergency Department (ED) - Float Pool - St. Francis Downtown
Posted yesterday
- RN
Nurse Practitioner - Pediatrics Acute Care
Posted 4 days ago
- NP
- Rotating shift
Registered Nurse (RN)-Nurse Informaticist, FT, Days-Hybrid
Posted last week
- RN
- Day shift
- RN
Registered Nurse (RN) - Float Pool - St. Francis Downtown - PRN
Posted yesterday
- RN
- Day shift
- Per diem
Nurse Practitioner - Pediatrics - Acute Care
Posted 4 days ago
- NP
- Rotating shift
- RN
- Night (United States of America)
- Per diem
Registered Nurse (RN) - Endoscopy Unit - St. Francis Downtown
Posted yesterday
- RN
- 10-hour days
- NP
- Rotating shift
- RN
- Day shift
- Compact license OK
Registered Nurse (RN) - Endoscopy Unit - St. Francis Downtown
Posted yesterday
- RN
- 8-hour days
Nurse Practitioner - OB/GYN .6 FTE
Posted last week
- NP
- Day shift
Working and living in Greenville
· 509 open roles
Living costs
- Median gross rent
- $1,312/mo
- Rent and tenant-paid utilities
- Median household income
- $71,472/yr
- All local households, not nurse pay
New to our board this week
61 current postings first appeared here in the past seven days.
Credentials accepted
- CRNA1
- CNM2
- NP45
- RN382
- LPN31
- LVN4
- CNA36
One posting may accept more than one credential.
Shifts listed
- Days228
- Nights135
- Rotating73
- per-diem21
- weekend4
- Evenings3
Postings may list several shifts or leave the shift unspecified.
Living in Greenville
Greenville’s distinct draw is a walkable downtown built around Falls Park on the Reedy and the Liberty Bridge, stitched to Travelers Rest by the 20-plus-mile Prisma Health Swamp Rabbit Trail, with the Blue Ridge, Paris Mountain, Table Rock, and lakes Keowee and Hartwell close enough for after-shift hikes.
More about life hereShow less
Five Forks, Simpsonville, and Mauldin are the family-and-schools suburbs along I-385; Greer offers a quieter pace and airport access; downtown and the West End put Main Street’s 200-plus restaurants—Nose Dive, Gather GVL’s shipping-container court, Sully’s Steamers—and Unity Park on foot. Average commute is about 17 minutes, but a car is required: transit is thin and growth has thickened I-85 and I-385 traffic.
Expect hot, humid summers, strong county schools, a family-forward culture, and rapid-growth tradeoffs of crowding, rising prices, and too many suburbs to parse.
Sources
Neighborhoods
Five Forks, a planned community southeast of downtown, is ranked the #1 Greenville suburb by Niche for excellent schools, low crime, newer construction, and highway access. Downtown and the West End offer walkable urban living in converted lofts and modern condos near Falls Park and Main Street.
Simpsonville on the Golden Strip along I-385 and Mauldin attract families and young professionals with new construction, growing retail, and I-385/I-85 access. Greer pairs a quieter pace with Greenville-Spartanburg International Airport and Lake Robinson; Facebook locals also recommend Travelers Rest, Easley, Woodruff, and Duncan for small-town feel and workable commutes.
Sources
Housing
Downtown means lofts and condos; Five Forks, Simpsonville, and Mauldin are newer suburban stock from starter homes to luxury; Greer and Travelers Rest are quieter, often more small-town. Rapid growth is pushing prices up, so affordable relative to big metros is the pitch, not cheap-city pricing.
Getting around
U.S. News reports an average commute of about 17 minutes in Greenville. Daily driving centers on I-385 through the Golden Strip (Mauldin, Simpsonville) and I-85; Greer sits between Greenville and Spartanburg with a short run to GSP Airport, and Reddit commenters call downtown-to-Powdersville an easy hop.
Limited public transportation means a car is effectively required, and rapid development has made traffic a leading complaint. The paved Prisma Health Swamp Rabbit Trail (20–22 miles, downtown to Travelers Rest) is the main bike-and-run alternative, not a hospital-shift transit system; sources do not describe hospital parking.
Food and dining
Downtown Main Street is the culinary core, with more than 200 restaurants and cafes and over 70 types of cuisine, from farm-to-table to international. Named stops include Nose Dive, Sully's Steamers, and Gather GVL, an outdoor food court of multicolored shipping containers housing 13 businesses.
Facebook locals call the city a foodie's paradise and mention breakfast culinary tours; breweries are a standard Reddit recommendation alongside downtown dining. Walkable clusters sit around Falls Park, Main Street, and the West End; sources do not map late-night options specifically to hospital campuses.
Outdoors
Falls Park on the Reedy is a 30-plus-acre downtown park around a natural waterfall, with gardens, overlooks, and the Liberty Bridge pedestrian span linking straight to Main Street. The Prisma Health Swamp Rabbit Trail is a paved 20–22-mile greenway from downtown to Travelers Rest, used daily for biking and running.
Nearby nature includes Unity Park, Paris Mountain, Table Rock State Park, the Blue Ridge foothills, and lakes Keowee, Hartwell, and Robinson. MoveCrew cites 46-plus parks, multiple golf courses, and hiking and mountain-biking trails, with mild weather supporting year-round outdoor use.
Arts and culture
Award-winning Main Street and Falls Park are the civic stage, with theaters, live music, and year-round festivals and events downtown and at Unity Park. Community lists include the Mountains to Mainstreet half marathon, a dense brewery scene, and Top Golf.
Gather GVL’s shipping-container food court doubles as a social hangout. VisitGreenvilleSC notes hundreds of national media mentions positioning the city among the Southeast’s top small-city destinations; nightlife is real downtown but is not described as late-night club-heavy.
Seasons and weather
The most concrete seasonal warning is hot, humid summers, a con called out in local realtor rundowns. Otherwise sources stress year-round mild weather that keeps the Swamp Rabbit Trail, Falls Park, and mountain day trips usable in most months.
The Blue Ridge, Paris Mountain, and Table Rock give a cooler-elevation escape when the Upstate is muggy; winter and fall are not detailed beyond that outdoor-friendly climate.
Sources
For families
Five Forks is the consensus family suburb—Niche’s #1 in the area—for excellent schools, low crime, and planned newer neighborhoods. Greenville County schools rank among South Carolina’s highest-rated, and Simpsonville and Mauldin are repeatedly sold on schools plus new construction.
The city is described as very family-friendly and a strong fit for couples and families, with 46-plus parks and a walkable downtown for weekends. Safety is generally strong in those named suburbs; cons include pockets of crime and growth-related crowding rather than a citywide danger narrative.
What locals say
Locals and relocators praise a beautiful, walkable downtown, strong schools, a family-friendly atmosphere, outdoor access, and relatively low taxes and overall cost of living. The recurring caveats are traffic, overcrowding from rapid in-migration, and rising costs—especially housing, which Reddit users single out as the expensive piece while other costs stay reasonable.
Further cons: hot humid summers, pockets of crime, car dependence, and too many suburbs to choose among. Sentiment is that it is great for couples and families more than a nightlife-first city, and still worth moving to if you pick the right suburb.

