22 nursing jobs in Florence, SC
Florence, South Carolina blends small-city comfort with genuine Southern hospitality. Its revitalized downtown historic district offers local dining and shops, while the surrounding Pee Dee region provides easy access to outdoor recreation. For an RN seeking a slower pace with strong community ties, Florence delivers everyday warmth and professional opportunity.
Also hiring: Florence, AL (15) · Florence, KY (6)
Find a nursing job in Florence
Hiring here: McLeod Health (7) · MUSC Health (5) · MUSC (2) · TNAA Healthcare (2) · Voyage Health (2) · Centerwell (1)
Registered Nurse (RN) MUSC Florence Ambulatory Surgery Center - FT
Florence, SC · Posted last week
- RN
- Compact license OK
- ADN accepted
- RN
- Night shift
- Compact license OK
- RN
- Per diem
- Compact license OK

MUSC Health
3 open roles · day & per diem shifts
MUSC Health
3 open roles · day & per diem shifts
MUSC Florence Day Hospital - FT
Florence, SC · Seen active last week
- RN
- Day shift
- Compact license OK
Registered Nurse (RN) - FT
Florence, SC
- RN
- Compact license OK
- ADN accepted
MUSC Leatherman
Florence, SC
- RN
- Per diem
- Compact license OK
Hospice Weekend Nurse - Hospice Homecare
Florence, SC · Posted last week
- Sign-on bonus
- RN
- 12-hour weekends only
Travel RN-ICU-Intensive Care Unit in Florence, South Carolina
$1,880/week
Florence, SC
- RN
- 12-hour nights
- Travel contract
Travel RN-CVICU-Cardiovascular Intensive Care Unit in Florence, South Carolina
$1,880/week
Florence, SC
- RN
- 12-hour nights
- Travel contract
McLeod Health
5 open roles · Hospital
McLeod Health
5 open roles · Hospital
Staff Nurse - Day Shift - Neuro Endovascular
Florence, SC
- Sign-on bonus
- RN
- 8-hour days
- Compact license OK
Physician Office - FT - RN - McLeod Cardiology Associates - Florence
Florence, SC · Seen active last week
- RN
- Per diem
Staff Nurse -full-time/days- Medical
Florence, SC · Seen active last week
- RN
- Day shift
- Floating required
- RN
- Day shift
Staff Nurse - WOW- Full-time - Observation
Florence, SC
- RN
- Weekend shift
- Floating required
Working and living in Florence
· 22 open roles in this snapshot
Living costs
- Median gross rent
- $992/mo
- Rent and tenant-paid utilities
- Median household income
- $56,143/yr
- All local households, not nurse pay
New to our board this week
1 current postings first appeared here in the past seven days.
Credentials accepted
- CRNA1
- RN20
- LPN1
One posting may accept more than one credential.
Shifts listed
- Days6
- per-diem5
- Nights4
- weekend2
Postings may list several shifts or leave the shift unspecified.