148 nursing jobs in Charleston, SC
With a cost of living just 1% above the national average, Charleston offers coastal living without extreme sticker shock. Relocating nurses often bypass pricey Peninsula and Mount Pleasant enclaves for accessible townhomes in West Ashley, Avondale, and Park Circle, balancing historic Lowcountry charm against practical carrying costs like flood exposure.
Also hiring: Charleston, WV (38)
Find a nursing job in Charleston
Hiring here: MUSC Health (30) · Veterans Health Administration (24) · Roper St. Francis Healthcare (14) · MUSC (12) · HealthTrust Workforce Solutions (5) · MUSC (5)
Oncology Med Surg Registered Nurse
Charleston, SC
- RN
- Compact license OK
- ADN accepted
Intake Nurse - RN - PRN
Charleston, SC
- RN
- Per diem
- ADN accepted
Registered Nurse II-Health
Charleston, SC
- RN
- Rotating shift
- Compact license OK
Registered Nurse (RN) Weekend Only – Nephrology – Roper Hospital
Charleston, SC · Posted 5 days ago
- RN
- RN
- Night shift
- Compact license OK
- RN
- ADN accepted
- Tuition reimbursement
- RN
- RN
- Rotating shift
- Compact license OK
- RN
- Day shift
- ADN accepted
- RN
- RN
- Shift/Schedule: 10:00am-10:00pm (2-12 hour shifts)
- ADN accepted
- RN
- RN
- Compact license OK
- Tuition reimbursement
- RN
- 8-hour days
- Compact license OK
Registered Nurse I (New Graduate) - NICU
Posted 2 weeks ago
- New grads welcomed
- RN
- 12-hour nights
- Neonatal Intensive Care Unit
- RN
- Day shift
Registered Nurse - OVERNIGHT
$35–$41/hr
- RN
- 7pm-7am
- Tuition reimbursement
- New grads welcomed · reported
- RN
- Rotating shift
- Nursing Department
Certified Nursing Assistant or Resident Assistant | Full-Time
Posted last week
- CNA
- RN
- Weekend shift
- Compact license OK
- RN
- 10-hour days
- Compact license OK
Registered Nurse - Med/Surg: $2310/Week
From $2,700/week
- RN
- Night shift
- Travel contract
Registered Nurse II - Neuro ICU
Posted 2 weeks ago
- RN
- 3 - 12 Hour Rotating Shifts per week, including some weekends
- Compact license OK
- RN
- Nights
RN Case Manager
$1,800–$2,500/week
- RN
- Day shift
- Compact license OK
Registered Nurse (RN) - Interventional Radiology
Up to $1,696/week
- RN
- 10-hour days
- Travel contract
- New grads welcomed
- RN
- Ratio 1:3–1:4
- 3-12 hour shifts. Shifts vary based on the needs of the department.
Registered Nurse I (New Graduate) - 8W Neuro Acute Care
Posted last week
- New grads welcomed
- RN
- 3 - 12 Hour rotating shifts per week, including some weekends
- Compact license OK
MUSC Health
3 open roles · rotating & per diem shifts · Permanent
MUSC Health
3 open roles · rotating & per diem shifts · Permanent
- RN
- Rotating shift
- SCTR Nexus Clinical Research Unit
Registered Nurse II - Adult Inpatient - Mental Health
Charleston, SC · Posted last week
- RN
- 12-hour shifts
- Compact license OK
Registered Nurse II - MSICU
Charleston, SC
- RN
- Rotating shift
- Compact license OK
Working and living in Charleston
· 148 open roles
Living costs
- Median gross rent
- $1,722/mo
- Rent and tenant-paid utilities
- Median household income
- $92,414/yr
- All local households, not nurse pay
New to our board this week
6 current postings first appeared here in the past seven days.
Credentials accepted
- NP1
- RN141
- LPN2
- CNA2
One posting may accept more than one credential.
Shifts listed
- Days52
- Rotating28
- Nights13
- per-diem4
- weekend2
Postings may list several shifts or leave the shift unspecified.
Living in Charleston
Charleston sells a Lowcountry mix few hospital towns can match: a walkable 1670 peninsula of pastel houses and cobblestones, beaches at Folly, Isle of Palms, and Sullivan's Island a short drive away, and a food scene that is the city's real nightlife—Husk, Magnolias, Halls Chophouse, 39 Rue de Jean, dockside oysters, and a dense downtown restaurant map.
More about life hereShow less
Nurses typically orbit MUSC on the peninsula or Roper St. Francis; West Ashley is the commute workhorse (about 10–25 minutes downtown) with more attainable single-family homes, townhomes, and condos, while Park Circle and Avondale draw younger budgets and Mount Pleasant and Daniel Island cost more for schools, the Ravenel Bridge, and water. Locals still mean it about Southern hospitality and a city voted most polite for years, but they also warn you will drive everywhere, sit in tourist and bridge traffic, pay high housing and insurance, and live with humid summers, insects, and hurricane-plus-tidal-flood risk.
Listings cooled toward a $480,000 metro median in 2026 while rents kept climbing past $2,100. Schools split: Mount Pleasant has the reputation; crowding and uneven quality show up elsewhere. Budget for a car and flood insurance.
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Neighborhoods
Young professionals are commonly steered to Avondale, Park Circle, and downtown Charleston, with commute time and budget as the usual filters. West Ashley is the central, more attainable band—established single-family houses, newer townhomes, and low-maintenance condos under mature trees, with shopping along Sam Rittenberg Boulevard and Ashley River Road—generally cheaper than Mount Pleasant or the peninsula.
Mount Pleasant is the premium suburb, from townhomes in Park West and Carolina Park up through luxury master-planned homes, plus beach access; Daniel Island is another relocator pick for convenience. Park Circle in North Charleston sits closest to Boeing and Joint Base Charleston and is a frequent younger-professional suggestion.
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Housing
August 2026 metro median listing price was $480,000, down from $505,000 a year earlier—the first real cooling in a decade—while Charleston's average rent hit $2,159, up 2.6% year over year; a separate snapshot cites about $523,511 average home price and $1,754 rent. West Ashley and the Park Circle/Avondale band are the more accessible rungs (older houses, townhomes, condos); Mount Pleasant, downtown historic, and Daniel Island are the premium tier.
Peninsula living is architecture and walkability; suburbs run single-family, Park West and Carolina Park townhomes, and new master-planned product. Insurance, utilities, and flood exposure add carrying cost beyond the sticker.
Getting around
MUSC sits downtown on the peninsula and Roper St. Francis is another major healthcare employer, so most nurse commutes are car trips into or across the peninsula. West Ashley is called a commuting champion at 10 to 25 minutes to downtown and 15 to 30 minutes to North Charleston.
Mount Pleasant is 15 to 30 minutes downtown via the Ravenel Bridge, where traffic backs up at peak hours, and 25 to 45 minutes to North Charleston; Park Circle is about 10 to 20 minutes to Boeing or Joint Base Charleston and 15 to 30 minutes downtown. Public transit and late-night options are limited, so a car is the practical default.
Sources
Food and dining
Food is the civic sport: shrimp and grits in unexpected preparations, dockside oyster roasts, high-end rooms, outdoor cafes, and dock-fresh seafood, with downtown carrying the bulk of listings (186 versus 22 in Mount Pleasant). Named tables include Magnolias, Husk, Halls Chophouse, 39 Rue de Jean for modern French, The Crab Shacks for seafood, and outdoor spots such as Saltwater Cowboys.
Categories run Southern, seafood, fine dining, international, casual, and a sizable brewery and wine-bar scene. Near-hospital reality is peninsula-centric—MUSC is downtown, where restaurants cluster—while late-night options citywide are described as limited.
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Outdoors
Beach access is the everyday outdoor pitch: Folly Beach, Isle of Palms, Sullivan's Island, and Kiawah Island sit in the metro orbit, and Mount Pleasant is sold on waterfront plus a relatively quick Ravenel Bridge crossing. West Ashley offers parks and mature tree cover along a commuting corridor; Johns Island is the slower Lowcountry water-and-sunset side.
On the peninsula, the River Walk, peaceful promenades, quiet parks, scenic paths, and historic alleys are the local alternatives to Rainbow Row crowds. Outdoor life is framed as year-round, then qualified by humid summers, insects, and flood and hurricane exposure.
Arts and culture
Culture is peninsula-first: Rainbow Row, Charleston City Market, St. Philip's Church, cobblestone streets, and pastel historic fabric in a city founded in 1670 and nicknamed the Holy City. Dining and nightlife concentrate downtown, with breweries, wine bars, and outdoor restaurant culture doing much of the evening work.
The economy's other face is Silicon Harbor tech plus aerospace and military (Boeing, Joint Base Charleston) alongside MUSC. Named sports teams, festivals, and music venues are barely specified in these sources; the lived cultural pitch is history, food, and politeness more than a big-league calendar.
Seasons and weather
Expect hot, humid summers with plenty of insects, a real hurricane season, and nuisance tidal flooding on the peninsula—though the NOAA gauge logged only 7 high-tide flood days in 2024 and 7 again in 2025, down from 19 in 2023 and the quietest stretch since 2018. Locals still advertise year-round outdoor living, palms, and sunsets, with decent weather as a pro. High season means heavier tourism, packed restaurants, and strained roads and infrastructure.
Winters and shoulder months are not described in detail here; the climate warning that actually shows up is summer heat plus water.
Sources
For families
Mount Pleasant is the neighborhood most often tied to excellent schools, amenities, and family suburban life; Daniel Island and West Ashley also appear on relocator shortlists. Reddit locals describe Remount through Goose Creek as generally safe and relatively affordable for middle-class families, with conditions getting sketchier closer in toward some North Charleston pockets.
Metro-wide, K-12 quality is called variable and school crowding is a named con. Safety texture is neighborhood-specific rather than city-uniform.
What locals say
Residents praise the people—Southern hospitality, neighbors who check in, a city voted most polite in America for eight years—and the historic beauty, nearby beaches, food, and outdoor life. The same voices hammer cost: food and activities run pricey, housing and insurance are high, and tourists plus newcomers who first came on vacation add crowding.
Heat, humidity, insects, hurricane and flood risk, tourist traffic, thin public transit, and uneven or crowded schools are the recurring cons. Rapid growth has made commute times a first-order decision, even as 2026 brought the first real cooling in home list prices in a decade while rents kept rising.