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148 nursing jobs in Charleston, SC

With a cost of living just 1% above the national average, Charleston offers coastal living without extreme sticker shock. Relocating nurses often bypass pricey Peninsula and Mount Pleasant enclaves for accessible townhomes in West Ashley, Avondale, and Park Circle, balancing historic Lowcountry charm against practical carrying costs like flood exposure.

Also hiring: Charleston, WV (38)

Charleston, SC on the map· Open the live map
MUSC Health Charleston workplace
MUSC Health Charleston — a workplace named in a current Charleston postingView MUSC Health Charleston →

Find a nursing job in Charleston

Hiring here: MUSC Health (30) · Veterans Health Administration (24) · Roper St. Francis Healthcare (14) · MUSC (12) · HealthTrust Workforce Solutions (5) · MUSC (5)

MUSC Health Charleston

Charleston, SC

RN

$52/hr

  • RN
  • 12-⁠hour nights
  • Travel contract
1 / 2

Oncology Med Surg Registered Nurse

HCA Healthcare Trident Hospital logoHCA Healthcare Trident Hospital

Charleston, SC

  • RN
  • Compact license OK
  • ADN accepted
1 / 2

Intake Nurse - RN - PRN

HCA Healthcare Live Oak Mental Health and Wellness

Charleston, SC

  • RN
  • Per diem
  • ADN accepted
1 / 2
  • RN
1 / 2

Resident Care Coordinator RN (Skilled Nursing)

Wellmore of Daniel Island logoWellmore of Daniel Island

Charleston, SC

  • RN
1 / 2

Registered Nurse II-Health

MUSC Children's Health

Charleston, SC

  • RN
  • Rotating shift
  • Compact license OK
1 / 4

Registered Nurse (RN) Weekend Only – Nephrology – Roper Hospital

Roper St. Francis Healthcare logoRoper St. Francis Healthcare

Charleston, SC · Posted 5 days ago

  • RN
HCA Healthcare Trident Hospital logo

HCA Healthcare Trident Hospital

Charleston, SC

  • RN
  • Night shift
  • Compact license OK

HCA Healthcare Live Oak Mental Health and Wellness

Charleston, SC

  • RN
  • ADN accepted
  • Tuition reimbursement

MUSC Children's Health

Charleston, SC

  • RN
  • Rotating shift
  • Compact license OK
Roper St. Francis Healthcare logo

Roper St. Francis Healthcare

Charleston, SC

  • RN
  • Day shift
  • ADN accepted
HCA Healthcare Trident Hospital logo

HCA Healthcare Trident Hospital

Charleston, SC

  • New grads welcomed
  • RN
  • Day shift
Roper St. Francis Healthcare logo

Roper St. Francis Healthcare

Charleston, SC

  • RN
  • Shift/Schedule: 10:00am-10:00pm (2-12 hour shifts)
  • ADN accepted
HCA Healthcare Trident Hospital logo

HCA Healthcare Trident Hospital

Charleston, SC

  • New grads welcomed
  • Day shift
Roper St. Francis Healthcare logo

Roper St. Francis Healthcare

Charleston, SC

  • RN
  • Compact license OK
  • Tuition reimbursement

Medical University of South Carolina

Charleston, SC

  • New grads welcomed
  • RN
  • 12-⁠hour nights
  • Neonatal Intensive Care Unit

Charleston Outlier - Regency Hospital - Florence

Charleston, SC

Clinical Liaison

Posted last week

$70,000–$85,000/year

  • RN
  • Day shift
Ashley River Healthcare logo

Ashley River Healthcare

Charleston, SC

  • RN
  • 7pm-7am
  • Tuition reimbursement

Insight Global

Charleston, SC

  • RN
  • 10-⁠hour days
  • Local contract

College of Southern Nevada

Charleston, SC

  • New grads welcomed · reported
  • RN
  • Rotating shift
  • Nursing Department

West Ashley Operations LLC

Charleston, SC

  • CNA

US Eye

Charleston, SC

  • RN
  • CEU allowance

MUSC

Charleston, SC

  • RN
  • Compact license OK

Roper St. Francis Healthcare

Charleston, SC

  • RN
  • Weekend shift
  • Compact license OK

Center For Sight

Charleston, SC

  • RN
  • CEU allowance
The Judge Group logo

The Judge Group

Charleston, SC

  • Magnet-designated
  • RN
  • 12-⁠hour days
  • Travel contract

Novant Health

Charleston, SC

  • RN
  • 12-⁠hour rotating
  • Per diem

Health Care Administrators Association® (HCAA)

Charleston, SC

  • RN
  • 10-⁠hour days
  • Compact license OK

State of South Carolina

Charleston, SC

  • RN
  • Night shift
  • Travel contract
MUSC Health logo

MUSC Health

Charleston, SC · Health system employer

  • RN
  • 3 - 12 Hour Rotating Shifts per week, including some weekends
  • Compact license OK
National Health - WHITE OAK LLC logo

National Health - WHITE OAK LLC

Charleston, SC

  • Sign-on bonus
  • RN
  • Monday-Friday, day shift
Oak Street Health logo

Oak Street Health

Charleston, SC

Registered Nurse

$54,000–$117,000/year

  • RN
Cherry Hill Free Clinic logo

Cherry Hill Free Clinic

Charleston, SC

  • RN
HealthTrust Workforce Solutions logo

HealthTrust Workforce Solutions

Charleston, SC

  • RN
  • Nights
AMN Healthcare logo

AMN Healthcare

Charleston, SC · Staffing partner

RN Case Manager

$1,800–$2,500/week

  • RN
  • Day shift
  • Compact license OK
ATC Healthcare Services of Georgia logo

ATC Healthcare Services of Georgia

Charleston, SC · Staffing partner

  • RN
  • 10-⁠hour days
  • Travel contract

MUSC

Charleston, SC

  • RN
  • 12-⁠hour rotating
  • Compact license OK
MUSC Health logo

MUSC Health

Charleston, SC · Health system employer

  • New grads welcomed
  • RN
  • Ratio 1:3–1:4
  • 3-12 hour shifts. Shifts vary based on the needs of the department.

MUSC

Charleston, SC

  • New grads welcomed · reported
  • RN
  • Rotating shift
  • MedSurg 7E
MUSC Health logo

MUSC Health

Charleston, SC · Health system employer

  • New grads welcomed
  • RN
  • 3 - 12 Hour rotating shifts per week, including some weekends
  • Compact license OK

MUSC

Charleston, SC

  • RN
  • Rotating shift
  • Compact license OK

MUSC Health

3 open roles · rotating & per diem shifts · Permanent

UNIV - Registered Nurse III - Department of SCTR

Charleston, SC

$69,000–$124,000/year

  • RN
  • Rotating shift
  • SCTR Nexus Clinical Research Unit
  • RN
  • 12-⁠hour shifts
  • Compact license OK
  • RN
  • Rotating shift
  • Compact license OK

Working and living in Charleston

· 148 open roles

Posted hourly pay

RN
$47/hr median
$36–$51/hr middle half · 10 postings

See roles with listed pay

Living costs

Metro price level
101.0 (100 = national)
BEA 2024
Median gross rent
$1,722/mo
Rent and tenant-paid utilities
Median household income
$92,414/yr
All local households, not nurse pay

Census ACS 2024

Open to new grads

22 postings explicitly welcome new grads.

Browse new grad roles

New to our board this week

6 current postings first appeared here in the past seven days.

Browse current openings

Credentials accepted

  • NP1
  • RN141
  • LPN2
  • CNA2

One posting may accept more than one credential.

Shifts listed

  • Days52
  • Rotating28
  • Nights13
  • per-diem4
  • weekend2

Postings may list several shifts or leave the shift unspecified.

Living in Charleston

Charleston sells a Lowcountry mix few hospital towns can match: a walkable 1670 peninsula of pastel houses and cobblestones, beaches at Folly, Isle of Palms, and Sullivan's Island a short drive away, and a food scene that is the city's real nightlife—Husk, Magnolias, Halls Chophouse, 39 Rue de Jean, dockside oysters, and a dense downtown restaurant map.

More about life here

Nurses typically orbit MUSC on the peninsula or Roper St. Francis; West Ashley is the commute workhorse (about 10–25 minutes downtown) with more attainable single-family homes, townhomes, and condos, while Park Circle and Avondale draw younger budgets and Mount Pleasant and Daniel Island cost more for schools, the Ravenel Bridge, and water. Locals still mean it about Southern hospitality and a city voted most polite for years, but they also warn you will drive everywhere, sit in tourist and bridge traffic, pay high housing and insurance, and live with humid summers, insects, and hurricane-plus-tidal-flood risk.

Listings cooled toward a $480,000 metro median in 2026 while rents kept climbing past $2,100. Schools split: Mount Pleasant has the reputation; crowding and uneven quality show up elsewhere. Budget for a car and flood insurance.

Sources
As of Sep 11, 2026
Neighborhoods

Young professionals are commonly steered to Avondale, Park Circle, and downtown Charleston, with commute time and budget as the usual filters. West Ashley is the central, more attainable band—established single-family houses, newer townhomes, and low-maintenance condos under mature trees, with shopping along Sam Rittenberg Boulevard and Ashley River Road—generally cheaper than Mount Pleasant or the peninsula.

Mount Pleasant is the premium suburb, from townhomes in Park West and Carolina Park up through luxury master-planned homes, plus beach access; Daniel Island is another relocator pick for convenience. Park Circle in North Charleston sits closest to Boeing and Joint Base Charleston and is a frequent younger-professional suggestion.

Sources
Housing

August 2026 metro median listing price was $480,000, down from $505,000 a year earlier—the first real cooling in a decade—while Charleston's average rent hit $2,159, up 2.6% year over year; a separate snapshot cites about $523,511 average home price and $1,754 rent. West Ashley and the Park Circle/Avondale band are the more accessible rungs (older houses, townhomes, condos); Mount Pleasant, downtown historic, and Daniel Island are the premium tier.

Peninsula living is architecture and walkability; suburbs run single-family, Park West and Carolina Park townhomes, and new master-planned product. Insurance, utilities, and flood exposure add carrying cost beyond the sticker.

Sources
Getting around

MUSC sits downtown on the peninsula and Roper St. Francis is another major healthcare employer, so most nurse commutes are car trips into or across the peninsula. West Ashley is called a commuting champion at 10 to 25 minutes to downtown and 15 to 30 minutes to North Charleston.

Mount Pleasant is 15 to 30 minutes downtown via the Ravenel Bridge, where traffic backs up at peak hours, and 25 to 45 minutes to North Charleston; Park Circle is about 10 to 20 minutes to Boeing or Joint Base Charleston and 15 to 30 minutes downtown. Public transit and late-night options are limited, so a car is the practical default.

Sources
Food and dining

Food is the civic sport: shrimp and grits in unexpected preparations, dockside oyster roasts, high-end rooms, outdoor cafes, and dock-fresh seafood, with downtown carrying the bulk of listings (186 versus 22 in Mount Pleasant). Named tables include Magnolias, Husk, Halls Chophouse, 39 Rue de Jean for modern French, The Crab Shacks for seafood, and outdoor spots such as Saltwater Cowboys.

Categories run Southern, seafood, fine dining, international, casual, and a sizable brewery and wine-bar scene. Near-hospital reality is peninsula-centric—MUSC is downtown, where restaurants cluster—while late-night options citywide are described as limited.

Sources
Outdoors

Beach access is the everyday outdoor pitch: Folly Beach, Isle of Palms, Sullivan's Island, and Kiawah Island sit in the metro orbit, and Mount Pleasant is sold on waterfront plus a relatively quick Ravenel Bridge crossing. West Ashley offers parks and mature tree cover along a commuting corridor; Johns Island is the slower Lowcountry water-and-sunset side.

On the peninsula, the River Walk, peaceful promenades, quiet parks, scenic paths, and historic alleys are the local alternatives to Rainbow Row crowds. Outdoor life is framed as year-round, then qualified by humid summers, insects, and flood and hurricane exposure.

Sources
Arts and culture

Culture is peninsula-first: Rainbow Row, Charleston City Market, St. Philip's Church, cobblestone streets, and pastel historic fabric in a city founded in 1670 and nicknamed the Holy City. Dining and nightlife concentrate downtown, with breweries, wine bars, and outdoor restaurant culture doing much of the evening work.

The economy's other face is Silicon Harbor tech plus aerospace and military (Boeing, Joint Base Charleston) alongside MUSC. Named sports teams, festivals, and music venues are barely specified in these sources; the lived cultural pitch is history, food, and politeness more than a big-league calendar.

Sources
Seasons and weather

Expect hot, humid summers with plenty of insects, a real hurricane season, and nuisance tidal flooding on the peninsula—though the NOAA gauge logged only 7 high-tide flood days in 2024 and 7 again in 2025, down from 19 in 2023 and the quietest stretch since 2018. Locals still advertise year-round outdoor living, palms, and sunsets, with decent weather as a pro. High season means heavier tourism, packed restaurants, and strained roads and infrastructure.

Winters and shoulder months are not described in detail here; the climate warning that actually shows up is summer heat plus water.

Sources
For families

Mount Pleasant is the neighborhood most often tied to excellent schools, amenities, and family suburban life; Daniel Island and West Ashley also appear on relocator shortlists. Reddit locals describe Remount through Goose Creek as generally safe and relatively affordable for middle-class families, with conditions getting sketchier closer in toward some North Charleston pockets.

Metro-wide, K-12 quality is called variable and school crowding is a named con. Safety texture is neighborhood-specific rather than city-uniform.

Sources
What locals say

Residents praise the people—Southern hospitality, neighbors who check in, a city voted most polite in America for eight years—and the historic beauty, nearby beaches, food, and outdoor life. The same voices hammer cost: food and activities run pricey, housing and insurance are high, and tourists plus newcomers who first came on vacation add crowding.

Heat, humidity, insects, hurricane and flood risk, tourist traffic, thin public transit, and uneven or crowded schools are the recurring cons. Rapid growth has made commute times a first-order decision, even as 2026 brought the first real cooling in home list prices in a decade while rents kept rising.

Sources

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