459 nursing jobs in Columbia, SC
Anchored by premier hospital systems, Columbia delivers a cost of living about 6% below the national average. Trade high overhead for shaded bungalows in Shandon, post-shift paddles where the Saluda and Broad rivers meet, and lively evenings across the Vista's brick-paved warehouse district. South Carolina’s capital offers nurses exceptional clinical pace and real room to breathe.
Also hiring: Columbia, MO (99) · Columbia, MD (80) · Columbia, TN (21)
Find a nursing job in Columbia
Hiring here: 250 Prisma Health-Midlands (171) · Prisma Health (87) · 270 Prisma Health Medical Group-Midlands (65) · Veterans Health Administration (18) · 121 Prisma Health-University Medical Group (9) · MUSC Health (9)
Registered Nurse (RN)-Ambulatory, Psychiatry, FT, Day
Columbia, SC · Posted 6 days ago
- New grads welcomed
- RN
RN - 7th South Medical
Columbia, SC · Posted last week
- Sign-on bonus
- RN
- Residency program
- NP
- Per diem
- NP
- Ambulatory Infusion Center
- Tuition reimbursement
- LPN
- Night shift
- +$3/hr differential
- RN
- Day shift
- New grads welcomed
- CNA
- Days
Anesthetist - Independent Contractor - Richland
Posted today
- CRNA
- Rotating shift
- RN
- Rotating shift
- Per diem
Registered Nurse (RN) - Home Health, Infusion, FT, Days
Posted last week
- RN
- Day (United States of America)
- Compact license OK
- RN
- Day shift
- Travel contract
- RN
- Day shift
- Per diem
- RN
APP - Neuro ICU - Columbia
Posted today
- NP
- Rotating shift
Healthcare Director / Director of Nursing (LPN)
Posted last week
- RN/LPN
- RN
- Night shift
- Compact license OK
Registered Nurse (RN)-Home Infusion Clinical Liaison, PRN, Days
Posted last week
- RN
- Day (United States of America)
- Per diem
- RN
- Night shift
- Per diem
- RN
- Day shift
- New grads welcomed
- RN
- Rotating shift
- Compact license OK
270 Prisma Health Medical Group-Midlands
3 open roles · day & rotating shifts · Permanent
270 Prisma Health Medical Group-Midlands
3 open roles · day & rotating shifts · Permanent
Nurse Practitioner / Physician Assistant - Pulmonology - Columbia
Columbia, SC · Posted 5 days ago
- NP
- Day shift
Registered Nurse (RN) -Ambulatory, Pulmonology Medical Office, FT, Day
Columbia, SC · Posted 5 days ago
- New grads welcomed
- RN
- Day shift
NP / PA - Surgery - Trauma - Columbia
Columbia, SC · Posted 5 days ago
- NP
- Rotating shift
Working and living in Columbia
· 458 open roles
Living costs
- Median gross rent
- $1,204/mo
- Rent and tenant-paid utilities
- Median household income
- $55,529/yr
- All local households, not nurse pay
New to our board this week
26 current postings first appeared here in the past seven days.
Credentials accepted
- CRNA5
- CNM3
- NP69
- RN361
- LPN21
- LVN4
- CNA3
One posting may accept more than one credential.
Shifts listed
- Days191
- Rotating90
- Nights85
- per-diem26
- Evenings4
- weekend1
Postings may list several shifts or leave the shift unspecified.
Living in Columbia
Columbia is a car-dependent capital where healthcare, state government, USC, and Fort Jackson anchor the job market, and housing still undercuts most coastal South Carolina cities.
More about life hereShow less
Nurses typically land in Forest Acres (lively shops and restaurants, Niche’s 2026 #1 suburb), Lexington or Irmo for Lake Murray and A+ schools, the Avenues in Cayce/West Columbia for a shorter drive, or Blythewood twenty minutes north for large lots and Blythewood High. Downtown’s Vista on Gervais Street, Five Points, and Shandon bungalows offer walkable food and Gamecocks energy; Soda City Market takes over Main Street on Saturdays.
Outdoors run from the Columbia Canal trail and Riverbanks Zoo to Congaree National Park’s old-growth boardwalk and lake weekends. Expect high-90s humid summers, sparse COMET bus service (Walk Score 35), vehicle personal-property taxes, and city crime cited well above the national average—reasons most families skip the urban core for Lexington, Chapin, or Blythewood even when they work in town.
Sources
Neighborhoods
Forest Acres is Niche’s 2026 #1 Columbia-area suburb (A+ overall, population 10,530): lively, with stores and restaurants, used by singles, professionals, and families (median home $186,900). Lexington (#2, A+ public schools, population 24,585, median $174,900) and Irmo (#3, lakeside and budget-friendlier at $123,600, peaceful neighbors) plus Chapin are the Lake Murray family defaults; Seven Oaks ($136,100) is another green, school-oriented option.
Reddit locals point to the Avenues in Cayce/West Columbia for commute ease and nicer streets. In-town, Shandon, Heathwood, and Elmwood Park are tree-lined bungalows and Victorians near Five Points; Blythewood (~20 minutes north, median $265,100) is large-lot bungalows, contemporaries, and ranches for people willing to drive.
Housing
Area median sale prices are cited around $259,000–$264,000. 2026 suburb medians: Irmo $123,600, Seven Oaks $136,100, Lexington $174,900, Forest Acres $186,900, Blythewood $265,100 (Blythewood median rent $1,256). Citywide average rent is cited at $1,502, with 1-bedrooms around $1,063–$1,196. Stock runs from Shandon/Heathwood bungalows and downtown/Vista living to large-lot ranches in Blythewood; true monthly cost also includes vehicle personal-property taxes and primary-residence rules, not just the list price.
Getting around
Columbia is car-dependent (Walk Score 35, Bike Score 35, Transit Score 0); the COMET bus runs but coverage is sparse, so owning a car is treated as necessary. Reddit locals flag the Avenues in Cayce and West Columbia as the best bet for an easier drive plus decent neighborhoods.
Blythewood is about 20 minutes north of the city; Columbia Metropolitan Airport (CAE) is about 20 minutes from downtown. Healthcare is a major local employer (Prisma Health among others), but sources describe daily life as driving, parking, and mixed development—not hospital-adjacent transit.
Food and dining
The Vista along Gervais Street is the densest restaurant row—Blue Marlin and smallSUGAR sit next to many other kitchens—while Five Points and Devine Street concentrate cafes, gastropubs, craft beer, and late-night spots. Saturday Soda City Market shuts down Main Street for vendors and food trucks and is the standing local recommendation.
Everyday eating is Southern: Lowcountry shrimp and grits, barbecue, and pimiento cheese, with tourism copy describing a scene that keeps adding new restaurants on top of those classics.
Outdoors
Congaree National Park, 20–30 minutes southeast, is old-growth bottomland forest with boardwalk hikes, canoeing/kayaking, and birding (check flood conditions). In town, the Columbia Canal and Riverfront Park Trail (flat, 3–7 mile options), Riverfront Park, and the Gervais Street Bridge cover daily walks and skyline views; Riverbanks Zoo & Garden and Sesquicentennial State Park (trails, lake, cabins) are the family defaults.
Lake Murray shapes weekends out of Irmo, Lexington, and Chapin. Blythewood adds Doko Meadows Park’s 2,500-seat amphitheater, Blythewood Park, and Cobblestone Park Golf Club (golf, pool, pickleball).
Sources
Arts and culture
Fall belongs to the University of South Carolina Gamecocks; downtown also holds the South Carolina State House, State Museum (four floors plus planetarium and observatory), Columbia Museum of Art, McKissick Museum on campus, and the African American History Monument. Soda City Market is the weekly civic ritual; Blythewood’s Doko Ribfest and Doko Meadows amphitheater bring regional acts and live music.
Nightlife and music concentrate in Five Points and the Vista rather than a single club district; performing arts and festivals are repeatedly listed among reasons people stay.
Seasons and weather
Summers often reach the high 90s with humidity that makes the heat feel worse—the adjustment newcomers are warned about most. Rainfall is high, and inland storm and hurricane effects still reach the Midlands even without Charleston-style coastal surge (a relative plus versus the coast).
Spring can be cool and sunny with lighter crowds than packed fall football weekends; guides push shoulder seasons for milder weather. Outdoor life (zoo, lake, Congaree, canal trail) runs year-round, but summer routines shrink to early mornings and air-conditioning.
For families
Lexington (Niche A+ public schools) and Blythewood (Blythewood High School, Bethel-Hanberry Elementary, large lots, safer than 94% of South Carolina cities) are the family strongholds; Irmo, Chapin, and Seven Oaks (safer than 52%, green space) are the other names parents repeat. Forest Acres ranks high for livability but is only safer than 46% of SC cities; Lexington is safer than 78% and Irmo 56%.
Citywide crime 49% above the national average is why families are steered to those suburbs even if they work in town. Kid defaults include Riverbanks Zoo & Garden, Sesquicentennial State Park, Doko Meadows, and Lake Murray communities.
What locals say
People who like it cite lower costs than Charleston, friendly pace, Lake Murray, farmers markets, rivers and state parks close in, and a healthcare/government/USC job base. Honest gripes that repeat: you drive everywhere; summers are brutally humid; city crime is cited 49% above the national average; vehicle/personal-property taxes surprise newcomers; some Lexington subdivisions feel cookie-cutter with tiny lawns and storage units.
Forest Acres reviewers rave about restaurants and convenience. Relocators are told this is a bundle of different lifestyles—downtown/Vista, in-town bungalows, lake suburbs, large-lot Blythewood—not one city, and inland living means less coastal surge risk than Charleston even though storms still hit.