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459 nursing jobs in Columbia, SC

Anchored by premier hospital systems, Columbia delivers a cost of living about 6% below the national average. Trade high overhead for shaded bungalows in Shandon, post-shift paddles where the Saluda and Broad rivers meet, and lively evenings across the Vista's brick-paved warehouse district. South Carolina’s capital offers nurses exceptional clinical pace and real room to breathe.

Also hiring: Columbia, MO (99) · Columbia, MD (80) · Columbia, TN (21)

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Prisma Health Richland workplace
Prisma Health Richland — a workplace named in a current Columbia postingView Prisma Health Richland →

Find a nursing job in Columbia

Hiring here: 250 Prisma Health-Midlands (171) · Prisma Health (87) · 270 Prisma Health Medical Group-Midlands (65) · Veterans Health Administration (18) · 121 Prisma Health-University Medical Group (9) · MUSC Health (9)

Prisma Health Richland

Columbia, SC

  • RN
  • 12-⁠hour nights
  • Travel contract
1 / 3

Registered Nurse (RN)-Ambulatory, Psychiatry, FT, Day

Prisma Health logoPrisma Health

Columbia, SC · Posted 6 days ago

  • New grads welcomed
  • RN
1 / 2

RN - 7th South Medical

Lexington Health logoLexington Health

Columbia, SC · Posted last week

  • Sign-on bonus
  • RN
  • Residency program
1 / 2

Registered Nurse

Life Care Center of Columbia SC

Columbia, SC

$70,000–$80,000/year

  • RN
Lexington Health logo

Lexington Health

Columbia, SC

  • Sign-on bonus
  • RN
  • 7p-7:30a
  • New grads welcomed

Life Care Center of Columbia SC

Columbia, SC

  • RN
  • ADN accepted
Lexington Health logo

Lexington Health

Columbia, SC

  • Sign-on bonus
  • RN
  • Day shift
  • New grads welcomed

Life Care Center of Columbia SC

Columbia, SC

  • RN
  • ADN accepted
New Life Home Care logo

New Life Home Care

Columbia, SC

  • RN
  • Day shift
  • Per diem
SENTA Partners logo

SENTA Partners

Columbia, SC

Registered Nurse - Pre-Op/PACU

Posted last week

$34–$38/hr

  • RN
  • Per diem
Option Care Enterprises, Inc. logo

Option Care Enterprises, Inc.

Columbia, SC

  • NP
  • Ambulatory Infusion Center
  • Tuition reimbursement

Lradac

Columbia, SC

Nurse, LPN - Part-time night-shift

Posted 2 weeks ago

$30–$42/hr

  • LPN
  • Night shift
  • +$3/hr differential

Elios Healthcare

Columbia, SC

  • RN
  • Day shift

Logistical Med & Beyond

Columbia, SC

  • RN/LPN/LVN

270 Prisma Health Medical Group-Midlands

Columbia, SC

  • New grads welcomed
  • CNA
  • Days
Vitality Living GROUP logo

Vitality Living GROUP

Columbia, SC

  • RN/LPN/LVN
Palmetto Surgery Center logo

Palmetto Surgery Center

Columbia, SC

  • RN
  • Day shift
SLC Services logo

SLC Services

Columbia, SC

License RN

$40–$50/hr

  • RN

RecSol Recovery Solutions

Columbia, SC

  • RN
  • Per diem
  • Tuition reimbursement
Palmetto Infusion logo

Palmetto Infusion

Columbia, SC

  • RN
  • Day shift
  • Per diem

121 Prisma Health-University Medical Group

Columbia, SC

  • CRNA
  • Rotating shift

Columbia AL Operations LLC

Columbia, SC

  • CNA

185 Prisma Health LTACH - Baptist

Columbia, SC

  • RN
  • Rotating shift
  • Per diem

140 Greenville Health Corporation

Columbia, SC

  • RN
  • Day (United States of America)
  • Compact license OK

Legacy Traditional Schools

Columbia, SC

  • RN
  • Tuition reimbursement

Prisma Health

Columbia, SC

  • RN
  • Day shift
  • Travel contract

Addus Homecare

Columbia, SC

  • RN
  • Per diem
Aura Health logo

Aura Health

Columbia, SC

  • RN

Maxim Healthcare

Columbia, SC

  • RN
Option Care Health logo

Option Care Health

Columbia, SC

  • RN

MUSC

Columbia, SC

  • Sign-on bonus
  • RN
  • Rotating shift
  • Compact license OK

CNSCares

Columbia, SC

  • RN
  • Night shift
  • Agency contract
Amedisys logo

Amedisys

Columbia, SC

Registered Nurse Home Health

Posted last week

$35/hr

  • RN
  • Day shift
  • Per diem
Zentech Consulting logo

Zentech Consulting

Columbia, SC · Staffing partner

  • RN
  • Day shift
  • Per diem

Logistical Med & Beyond

Columbia, SC

  • RN

270 Prisma Health Medical Group-Midlands

Columbia, SC

  • NP
  • Rotating shift

Columbia AL Operations LLC

Columbia, SC

  • RN/LPN

185 Prisma Health LTACH - Baptist

Columbia, SC

  • RN
  • Night shift
  • Compact license OK

140 Greenville Health Corporation

Columbia, SC

  • RN
  • Day (United States of America)
  • Per diem

270 Prisma Health Medical Group-Midlands

Columbia, SC

  • RN
  • Day shift

Columbia AL Operations LLC

Columbia, SC

  • RN/LPN

185 Prisma Health LTACH - Baptist

Columbia, SC

  • New grads welcomed
  • RN
  • Rotating shift
  • Compact license OK

270 Prisma Health Medical Group-Midlands

3 open roles · day & rotating shifts · Permanent

  • NP
  • Day shift
  • New grads welcomed
  • RN
  • Day shift

NP / PA - Surgery - Trauma - Columbia

Columbia, SC · Posted 5 days ago

  • NP
  • Rotating shift

Working and living in Columbia

· 458 open roles

Posted hourly pay

RN
$37/hr median
$31–$43/hr middle half · 18 postings

See roles with listed pay

Living costs

Metro price level
93.7 (100 = national)
BEA 2024
Median gross rent
$1,204/mo
Rent and tenant-paid utilities
Median household income
$55,529/yr
All local households, not nurse pay

Census ACS 2024

Open to new grads

80 postings explicitly welcome new grads.

Browse new grad roles

New to our board this week

26 current postings first appeared here in the past seven days.

Browse current openings

Credentials accepted

  • CRNA5
  • CNM3
  • NP69
  • RN361
  • LPN21
  • LVN4
  • CNA3

One posting may accept more than one credential.

Shifts listed

  • Days191
  • Rotating90
  • Nights85
  • per-diem26
  • Evenings4
  • weekend1

Postings may list several shifts or leave the shift unspecified.

Living in Columbia

Columbia is a car-dependent capital where healthcare, state government, USC, and Fort Jackson anchor the job market, and housing still undercuts most coastal South Carolina cities.

More about life here

Nurses typically land in Forest Acres (lively shops and restaurants, Niche’s 2026 #1 suburb), Lexington or Irmo for Lake Murray and A+ schools, the Avenues in Cayce/West Columbia for a shorter drive, or Blythewood twenty minutes north for large lots and Blythewood High. Downtown’s Vista on Gervais Street, Five Points, and Shandon bungalows offer walkable food and Gamecocks energy; Soda City Market takes over Main Street on Saturdays.

Outdoors run from the Columbia Canal trail and Riverbanks Zoo to Congaree National Park’s old-growth boardwalk and lake weekends. Expect high-90s humid summers, sparse COMET bus service (Walk Score 35), vehicle personal-property taxes, and city crime cited well above the national average—reasons most families skip the urban core for Lexington, Chapin, or Blythewood even when they work in town.

Sources
As of Sep 11, 2026
Neighborhoods

Forest Acres is Niche’s 2026 #1 Columbia-area suburb (A+ overall, population 10,530): lively, with stores and restaurants, used by singles, professionals, and families (median home $186,900). Lexington (#2, A+ public schools, population 24,585, median $174,900) and Irmo (#3, lakeside and budget-friendlier at $123,600, peaceful neighbors) plus Chapin are the Lake Murray family defaults; Seven Oaks ($136,100) is another green, school-oriented option.

Reddit locals point to the Avenues in Cayce/West Columbia for commute ease and nicer streets. In-town, Shandon, Heathwood, and Elmwood Park are tree-lined bungalows and Victorians near Five Points; Blythewood (~20 minutes north, median $265,100) is large-lot bungalows, contemporaries, and ranches for people willing to drive.

Sources
Housing

Area median sale prices are cited around $259,000–$264,000. 2026 suburb medians: Irmo $123,600, Seven Oaks $136,100, Lexington $174,900, Forest Acres $186,900, Blythewood $265,100 (Blythewood median rent $1,256). Citywide average rent is cited at $1,502, with 1-bedrooms around $1,063–$1,196. Stock runs from Shandon/Heathwood bungalows and downtown/Vista living to large-lot ranches in Blythewood; true monthly cost also includes vehicle personal-property taxes and primary-residence rules, not just the list price.

Sources
Getting around

Columbia is car-dependent (Walk Score 35, Bike Score 35, Transit Score 0); the COMET bus runs but coverage is sparse, so owning a car is treated as necessary. Reddit locals flag the Avenues in Cayce and West Columbia as the best bet for an easier drive plus decent neighborhoods.

Blythewood is about 20 minutes north of the city; Columbia Metropolitan Airport (CAE) is about 20 minutes from downtown. Healthcare is a major local employer (Prisma Health among others), but sources describe daily life as driving, parking, and mixed development—not hospital-adjacent transit.

Sources
Food and dining

The Vista along Gervais Street is the densest restaurant row—Blue Marlin and smallSUGAR sit next to many other kitchens—while Five Points and Devine Street concentrate cafes, gastropubs, craft beer, and late-night spots. Saturday Soda City Market shuts down Main Street for vendors and food trucks and is the standing local recommendation.

Everyday eating is Southern: Lowcountry shrimp and grits, barbecue, and pimiento cheese, with tourism copy describing a scene that keeps adding new restaurants on top of those classics.

Sources
Outdoors

Congaree National Park, 20–30 minutes southeast, is old-growth bottomland forest with boardwalk hikes, canoeing/kayaking, and birding (check flood conditions). In town, the Columbia Canal and Riverfront Park Trail (flat, 3–7 mile options), Riverfront Park, and the Gervais Street Bridge cover daily walks and skyline views; Riverbanks Zoo & Garden and Sesquicentennial State Park (trails, lake, cabins) are the family defaults.

Lake Murray shapes weekends out of Irmo, Lexington, and Chapin. Blythewood adds Doko Meadows Park’s 2,500-seat amphitheater, Blythewood Park, and Cobblestone Park Golf Club (golf, pool, pickleball).

Sources
Arts and culture

Fall belongs to the University of South Carolina Gamecocks; downtown also holds the South Carolina State House, State Museum (four floors plus planetarium and observatory), Columbia Museum of Art, McKissick Museum on campus, and the African American History Monument. Soda City Market is the weekly civic ritual; Blythewood’s Doko Ribfest and Doko Meadows amphitheater bring regional acts and live music.

Nightlife and music concentrate in Five Points and the Vista rather than a single club district; performing arts and festivals are repeatedly listed among reasons people stay.

Sources
Seasons and weather

Summers often reach the high 90s with humidity that makes the heat feel worse—the adjustment newcomers are warned about most. Rainfall is high, and inland storm and hurricane effects still reach the Midlands even without Charleston-style coastal surge (a relative plus versus the coast).

Spring can be cool and sunny with lighter crowds than packed fall football weekends; guides push shoulder seasons for milder weather. Outdoor life (zoo, lake, Congaree, canal trail) runs year-round, but summer routines shrink to early mornings and air-conditioning.

Sources
For families

Lexington (Niche A+ public schools) and Blythewood (Blythewood High School, Bethel-Hanberry Elementary, large lots, safer than 94% of South Carolina cities) are the family strongholds; Irmo, Chapin, and Seven Oaks (safer than 52%, green space) are the other names parents repeat. Forest Acres ranks high for livability but is only safer than 46% of SC cities; Lexington is safer than 78% and Irmo 56%.

Citywide crime 49% above the national average is why families are steered to those suburbs even if they work in town. Kid defaults include Riverbanks Zoo & Garden, Sesquicentennial State Park, Doko Meadows, and Lake Murray communities.

Sources
What locals say

People who like it cite lower costs than Charleston, friendly pace, Lake Murray, farmers markets, rivers and state parks close in, and a healthcare/government/USC job base. Honest gripes that repeat: you drive everywhere; summers are brutally humid; city crime is cited 49% above the national average; vehicle/personal-property taxes surprise newcomers; some Lexington subdivisions feel cookie-cutter with tiny lawns and storage units.

Forest Acres reviewers rave about restaurants and convenience. Relocators are told this is a bundle of different lifestyles—downtown/Vista, in-town bungalows, lake suburbs, large-lot Blythewood—not one city, and inland living means less coastal surge risk than Charleston even though storms still hit.

Sources

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