39 nursing jobs in Simpsonville, SC
Anchoring Greenville's Golden Strip, Simpsonville puts Prisma Health Hillcrest Hospital minutes away and downtown trauma centers a 20-minute I-385 drive. Off shift, unwind at The Warehouse at Vaughn’s or catch shows at Heritage Park’s 15,000-seat CCNB Amphitheatre, returning home to leafy, established enclaves like Neely Farm and Powderhorn.
Find a nursing job in Simpsonville
Hiring here: 110 Prisma Health-Upstate (18) · 121 Prisma Health-University Medical Group (7) · Prisma Health (6) · 170 Prisma Health (2) · American Traveler (2) · ATC Healthcare Services of Georgia (1)

Prisma Health
6 open roles · day & rotating shifts
Prisma Health
6 open roles · day & rotating shifts
Licensed Practical Nurse (LPN) - Ambulatory Practice, Five Forks Internal Medicine, FT
Simpsonville, SC
- LPN
Licensed Practical Nurse (LPN)-Ambulatory
Simpsonville, SC
- LPN
- Day shift
- RN
- Rotating shift
- Per diem
Registered Nurse (RN) - Ambulatory Care, Gastroenterology, FT
Simpsonville, SC
- New grads welcomed
- RN
- Day shift
- Compact license OK
Registered Nurse (RN) Acute Care, Med/Surg Telemetry, PRN, Days
Simpsonville, SC
- RN
- Day shift
- Per diem
Registered Nurse (RN) Acute Care, Med/Surg Telemetry, FT, Days
Simpsonville, SC
- RN
- Day shift
- Per diem
Registered Nurse (RN)-Value Analysis Manager, FT, Days
Posted last week
- RN
- Day
- Compact license OK
Patient Observer, Sitters/Observers, PRN, Variable shifts
Posted yesterday
- CNA
- Rotating shift
- Per diem
- NP
- Day shift
- RN
- ADN accepted
- Tuition reimbursement
Registered Nurse (RN) - MedSurg / Tele
Up to $1,915/week
- RN
- 12-hour nights
- Travel contract
- RN
- Travel contract
- RN
- 12-hour days
- Travel contract
Registered Nurse (RN)-Value Analysis Manager, FT, Days
Posted last week
- RN
- Day (United States of America)
- Compact license OK
Registered Nurse (RN) Acute Care, Operating Room, FT, Days
Posted 4 days ago
- RN
- Day shift
Nurse Practitioner / Physician Assistant - ENT - Golden Strip
Posted last week
- NP
- Day
Travel RN - Med/Surg Tele
$1,866/week
- RN
- Ratio 1:5–1:6
- 7:00 AM to 7:30 PM
Registered Nurse (RN) - Acute Care, Facility Resource Pool, Laurens/Hillcrest, PRN, Nights
Posted last week
- RN
- Night shift
- Per diem
Licensed Practical Nurse (LPN) - Ambulatory Practice, Five Forks Internal Medicine, FT
Posted last week
- New grads welcomed
- LPN
- Day (United States of America)
- Compact license OK
Registered Nurse (RN) Acute Care, ICU, FT, Nights
Posted last week
- RN
- Night shift
Nurse Practitioner / Physician Assistant - ENT - Golden Strip
Posted last week
- NP
- Day (United States of America)
- RN
- Night shift
- Per diem
Nurse Practitioner / Physician Assistant - ENT - Greer
Posted last week
- NP
- Day (United States of America)
Registered Nurse (RN) Acute Care, Med/Surg Telemetry, PRN, Days
Posted last week
- RN
- Day (United States of America)
- Per diem
- New grads welcomed
- LPN
- Day (United States of America)
- Compact license OK
- RN
- This is a mid-shift position (1pm-1am)
- Compact license OK
- New grads welcomed
- LPN
- Day (United States of America)
- Compact license OK
110 Prisma Health-Upstate
11 open roles · Hospital
110 Prisma Health-Upstate
11 open roles · Hospital
(RN) Acute Care, Med/Surg Telemetry, PRN, Nights
Simpsonville, SC · Posted last week
- RN
- Night
- Per diem
(RN)–Nurse Resident, December 2026, Med Surg/Telemetry
Simpsonville, SC · Posted last week
- New grads welcomed
- RN
- Rotating shift
- Compact license OK
(RN) Acute Care, Med/Surg Telemetry, FT, Variable
Simpsonville, SC · Posted last week
- RN
- This is a mid-shift position (1pm-1am)
- Compact license OK
(RN) Acute Care, Adult Multispecialty, PRN, Nights
Simpsonville, SC · Posted last week
- RN
- Night (United States of America)
- Per diem
(RN) Acute Care, Med/Surg Telemetry, FT, Days
Simpsonville, SC · Posted last week
- RN
- Day (United States of America)
- Compact license OK
(RN) Acute Care, Med/Surg Telemetry (ADT), FT, Days
Simpsonville, SC · Posted last week
- RN
- Day shift
- Compact license OK
(RN) Acute Care, Operating Room, PT, Days
Simpsonville, SC · Posted last week
- RN
- 10-hour days
- Compact license OK
(RN) Acute Care, Radiology, PRN, Days
Simpsonville, SC · Posted last week
- RN
- Days
- Per diem
(RN)–Nurse Resident, Winter 2027, Med Surg/Telemetry
Simpsonville, SC · Posted last week
- New grads welcomed
- RN
- Rotating shift
- Compact license OK
(RN), Acute Care, Med/Surg Telemetry, FT, Nights
Simpsonville, SC · Posted last week
- RN
- Night
- Compact license OK
(RN) Acute Care, Emergency Trauma Center, PRN, Variable
Simpsonville, SC · Posted last week
- RN
- Variable
- Emergency Department
Working and living in Simpsonville
· 39 open roles
Living costs
- Median gross rent
- $1,415/mo
- Rent and tenant-paid utilities
- Median household income
- $82,457/yr
- All local households, not nurse pay
New to our board this week
3 current postings first appeared here in the past seven days.
Credentials accepted
- NP5
- RN28
- LPN5
- CNA1
One posting may accept more than one credential.
Shifts listed
- Days21
- Nights7
- Rotating6
- Evenings2
Postings may list several shifts or leave the shift unspecified.
Living in Simpsonville
Anchoring Greenville County's 'Golden Strip,' Simpsonville delivers a suburban retreat that balances historic Upstate railroad roots with rapid modern expansion.
More about life hereShow less
For relocating healthcare professionals, the town offers the convenience of Prisma Health Hillcrest Hospital right in town, while placing Greenville's major hospital networks just a 20- to 25-minute drive up Interstate 385. Off shift, daily life revolves around a revamped downtown district centered on its iconic brick clock tower, where you can grab coffee at Exchange Coffee Co., sample Lowcountry dishes at Stella’s Southern Bistro, or meet friends for outdoor drinks at The Warehouse at Vaughn’s. Housing options range from mature, tree-lined communities like Neely Farm and Powderhorn to sprawling newer builds in Five Forks and custom manors in Cobblestone.
However, living here requires adjusting to complete car dependency and navigating severe peak congestion along Fairview and Woodruff Roads. If you value tight-knit neighborhoods, top-rated schools, and major concerts at the 15,000-seat CCNB Amphitheatre at Heritage Park over urban walkability, Simpsonville offers a functional, grounded Upstate base.
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Neighborhoods
Simpsonville offers a broad mix of established subdivisions and master-planned developments. Powderhorn and Neely Farm provide mature tree canopies, large lots, and active community swim and tennis leagues, with Powderhorn sitting within walking distance of downtown dining.
River Walk, located near the Five Forks and Mauldin border, is centered around a four-mile trail along Gilder Creek and extensive athletic amenities. Buyers seeking executive brick and stone homes gravitate toward Cobblestone near Roper Mountain Road, while South Main Place caters to those seeking newer construction directly adjacent to downtown entertainment.
Commuters balancing hospital shifts benefit from living west or east of Interstate 385 depending on whether their route routes via Fairview Road or the Woodruff Road commercial strip.
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Housing
Residential inventory in Simpsonville consists predominantly of detached single-family subdivisions across distinct development eras. Older neighborhoods like Powderhorn and Neely Farm feature traditional brick or siding homes on generous, wooded lots with mature trees.
In contrast, rapid expansion around Five Forks and South Main Place showcases newer planned subdivisions, craftsman-inspired builds, and attached townhomes, often tied to mandatory homeowners associations with smaller lot footprints. Luxury buyers typically look toward custom estates on large parcels in enclaves like Cobblestone, while practical rentals and starter subdivisions concentrate close to the retail corridors off Fairview Road.
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Getting around
Healthcare workers stationed at Prisma Health Hillcrest Hospital enjoy short cross-town commutes within Simpsonville city limits. Those commuting to major health systems and Level 1 trauma facilities in downtown Greenville rely on Interstate 385, typically facing a 20- to 25-minute drive under clear conditions, with Interstate 85 providing regional connections toward Spartanburg and Anderson.
Public transit options are virtually nonexistent for hospital shift schedules, necessitating personal vehicles. Peak-hour congestion creates substantial bottlenecks along primary commercial arteries, particularly Fairview Road and Woodruff Road near Five Forks.
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Food and dining
Downtown Simpsonville centers around Main Street, where nurses can grab morning espresso at Exchange Coffee Co. or Chestnut Coffee and off-shift meals at Farm Fresh Fast, The Slice, or Stella's Southern Bistro for Lowcountry cooking. The Warehouse at Vaughn’s acts as a central food hall and outdoor gathering hub with rotating food stalls, smash burgers, and craft taps, complemented nearby by Unterhausen The Castle Cellar Pub and the Ice Cream Station housed in a 1960 train depot.
Additional dining corridors line Fairview Road, home to Select and everyday regional staples, with specialty grocers like Trader Joe's and Whole Foods accessible along Woodruff Road.
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Outdoors
Heritage Park serves as the city’s recreational anchor, featuring walking trails, athletic complexes, and open picnic space. Nearby Southside Park houses the Discovery Island Waterpark, drawing crowds for its lazy river, FlowRider continuous wave simulator, water slides, and outdoor pickleball courts.
Cyclists and runners benefit from connections into the expanding Swamp Rabbit Trail network through the Upstate. For weekend wilderness getaways, mountain hiking trails, waterfalls, and scenic overlooks at Caesars Head State Park and Table Rock State Park sit under an hour away.
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Arts and culture
Simpsonville punches above its suburban weight in live entertainment thanks to the 15,000-capacity CCNB Amphitheatre at Heritage Park, which hosts major national touring acts, Movies in the Park, and the multi-day spring Fair at Heritage Park. Downtown community culture focuses on the landmark 1986 brick clock tower along the historic rail line, bringing seasonal farmer's markets, Halloween parades, and winter tree-lighting festivals.
Regional performing arts and sports—such as Broadway touring shows at the Peace Center and Greenville Swamp Rabbits professional hockey at the Bon Secours Wellness Arena—are an easy evening drive away in Greenville.
Seasons and weather
Summers in the Upstate are hot and humid, prompting heavy local use of Discovery Island Waterpark and shady residential trail networks along Gilder Creek. Autumn brings milder temperatures, peak concert lineups and fall festivals at the CCNB Amphitheatre, and easy access to fall foliage in the nearby Blue Ridge foothills.
Winters are comparatively mild, marked by downtown holiday open houses, Christmas parades, and indoor sports outings like Swamp Rabbits hockey games through the early spring, when community fairs and farmer's markets resume outdoors.
For families
Simpsonville is widely sought after by families due to its zoning within the Greenville County School District, which incorporates school choice policies alongside highly rated institutions like Monarch Elementary, Bells Crossing Elementary, Rudolph Gordon School, Beck Academy, JL Mann High, Mauldin High, and Woodmont High. Community life is heavily oriented around youth leagues, neighborhood swim and tennis teams, and educational events hosted at both the Simpsonville and Five Forks public library branches.
Family recreation is anchored by Southside Park’s water attractions and youth sports complexes across town.
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What locals say
Residents and newcomers describe Simpsonville as a clean, safe, and family-oriented alternative to living in core Greenville, appreciating its small-town civic pride and quick access to major big-box retailers. The walkable downtown core around the clock tower and community green spaces like Heritage Park receive frequent praise.
Conversely, community members frequently voice frustration over rapid suburban sprawl outstripping local roads, leading to heavy gridlock along Fairview Road and Woodruff Road, alongside strict HOA governance and small lot sizes in newer subdivisions.