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38 nursing jobs in Odessa, TX

Anchoring the rugged expanse of the Permian Basin, Odessa combines classic West Texas grit with a critical regional healthcare footprint. Your paycheck stretches further here, with living costs about 6% below the national average. Trade traffic for wide-open skies, legendary Friday night football at Ratliff Stadium, and high-acuity nursing where your clinical skills make an immediate, outsized impact.

Odessa, TX on the map· Open the live map
The Parks Senior Living and Rehabilitation workplace
The Parks Senior Living and Rehabilitation — a workplace named in a current Odessa postingView The Parks Senior Living and Rehabilitation →

Find a nursing job in Odessa

Hiring here: TGN - A.T. Staffing (6) · Medical Center Health System (5) · Medical Center Hospital (4) · TNAA Healthcare (4) · American Traveler (2) · Grifols (2)

The Parks Senior Living and Rehabilitation

Odessa, TX

Registered Nurse

From $38/hr

  • New grads welcomed
  • RN
  • Night shift
  • Per diem
1 / 2
  • RN
  • 8-⁠hour days
  • Tuition reimbursement
1 / 2

Registered Nurse - Postpartum - Days

Odessa Regional Medical Center logoOdessa Regional Medical Center

Odessa, TX · Posted 3 days ago

  • RN

Two Hearts Home Health

Odessa, TX

Registered Nurse

$30–$40/hr

  • RN

Medical Center Hospital

Odessa, TX

Clinical RN or LVN

Posted last week

  • RN/LVN
Community Hospital logo

Community Hospital

Odessa, TX

  • RN
  • Day shift
  • Compact license OK
United Surgical Partners International, Inc logo

United Surgical Partners International, Inc

Odessa, TX

  • RN
  • Day shift

Odessa Medical Group

Odessa, TX

  • RN
  • Per diem
Grifols logo

Grifols

Odessa, TX

  • Sign-on bonus
  • LVN
  • Night shift
  • Tuition reimbursement
Jayes Tech LLC logo

Jayes Tech LLC

Odessa, TX

  • New grads welcomed

Krucial Rapid Response

Odessa, TX

  • RN
  • Travel contract

CorrHealth

Odessa, TX

  • RN

Medical Center Health System

Odessa, TX · Health system employer

Clinical RN

Posted last week

  • RN

STAR Care

Odessa, TX

  • LVN
Odessa Regional Medical Center logo

Odessa Regional Medical Center

Odessa, TX

  • Sign-on bonus
  • RN
  • 12-⁠hour days
TNAA Healthcare logo

TNAA Healthcare

Odessa, TX · Staffing partner

RN NICU

$2,800/week

  • RN
  • Travel contract
American Traveler logo

American Traveler

Odessa, TX · Staffing partner

Travel RN - ICU

Posted last week

$1,818/week

  • RN
  • Travel contract
Voyage Health logo

Voyage Health

Odessa, TX · Staffing partner

Travel RN PCU

$2,580–$2,716/week

  • RN
  • 12-⁠hour days
  • Travel contract

TGN - A.T. Staffing

Odessa, TX · Staffing partner

  • RN
  • Travel contract

Fusion Medical Staffing

Odessa, TX · Staffing partner

ICU RN

$1,550–$1,649/week

  • RN
  • Travel contract
  • CEU allowance

Medical Center Hospital

Odessa, TX

  • New grads welcomed
  • RN
  • Day Shift, 40 plus
  • Radiology Special Procedures
Grifols logo

Grifols

Odessa, TX

  • Sign-on bonus
  • RN
  • Tuition reimbursement

Medical Center Health System

Odessa, TX · Health system employer

Clinical RN

Posted last week

  • RN
  • Varied work hours and shifts
TNAA Healthcare logo

TNAA Healthcare

Odessa, TX · Staffing partner

  • RN
  • Travel contract
American Traveler logo

American Traveler

Odessa, TX · Staffing partner

Travel RN - ICU

Posted last week

$1,818/week

  • RN
  • Travel contract

TGN - A.T. Staffing

Odessa, TX · Staffing partner

  • RN
  • 12-⁠hour days
  • Travel contract

Medical Center Hospital

Odessa, TX

Clinical RN

Posted 4 days ago

  • RN

Medical Center Health System

Odessa, TX · Health system employer

  • RN
TNAA Healthcare logo

TNAA Healthcare

Odessa, TX · Staffing partner

Med Surg RN

$1,602/week

  • RN
  • Day shift
  • Travel contract

TGN - A.T. Staffing

Odessa, TX · Staffing partner

  • Travel contract

Medical Center Hospital

Odessa, TX

Clinical RN

Posted last week

  • RN

Medical Center Health System

Odessa, TX · Health system employer

  • RN
  • Varied work hours and shifts
TNAA Healthcare logo

TNAA Healthcare

Odessa, TX · Staffing partner

Telemetry RN

$2,029/week

  • RN
  • Travel contract

TGN - A.T. Staffing

Odessa, TX · Staffing partner

  • RN
  • 12-⁠hour nights
  • Travel contract

Medical Center Hospital

Odessa, TX

  • RN
  • 12-⁠hour nights

Medical Center Health System

Odessa, TX · Health system employer

  • RN

TGN - A.T. Staffing

Odessa, TX · Staffing partner

  • 8-⁠hour nights
  • Travel contract

TGN - A.T. Staffing

Odessa, TX · Staffing partner

  • RN
  • 12-⁠hour days
  • Travel contract

Working and living in Odessa

· 38 open roles

Living costs

Metro price level
93.9 (100 = national)
BEA 2024
Median gross rent
$1,315/mo
Rent and tenant-paid utilities
Median household income
$73,472/yr
All local households, not nurse pay

Census ACS 2024

Open to new grads

3 postings explicitly welcome new grads.

Browse new grad roles

New to our board this week

6 current postings first appeared here in the past seven days.

Browse current openings

Credentials accepted

  • RN33
  • LVN3

One posting may accept more than one credential.

Shifts listed

  • Days9
  • Nights5
  • Rotating2

Postings may list several shifts or leave the shift unspecified.

Living in Odessa

Odessa delivers an unapologetically authentic slice of West Texas, driven by the industrious energy of the Permian Basin, storied Friday night football traditions, and expansive desert skies.

More about life here

For relocating healthcare professionals, the city provides robust clinical employment alongside a straightforward, unpretentious lifestyle. Residential pockets like Mission Estates, Parks Legado, and the corridors around John Ben Sheppard Parkway provide comfortable suburban neighborhoods, while downtown offers local character at spots like Barrel and Derrick, Masa Bakery, and the historic Ector Theatre.

Community life balances quirky cultural staples—such as the Shakespearean Globe of the Great Southwest, the Ellen Noël Art Museum, and the campus Stonehenge replica—with relaxation at Comanche Trail Park. Relocating nurses should plan for practical regional tradeoffs: the semi-arid climate brings intense summer heat and periodic spring dust storms, and heavy commercial oilfield traffic on the Loop and Andrews Highway demands attentive driving.

Approached with clear expectations, Odessa offers nurses a hardworking, deeply hospitable community with a distinctive frontier spirit.

Sources
As of Sep 16, 2026
Neighborhoods

Suburban master-planned developments such as Mission Estates and Parks Legado offer quiet residential settings with quick access to retail and dining. Newer single-family subdivisions and apartment communities are clustered along John Ben Sheppard Parkway, Rocky Lane Road, Deering Road, and the outer State Loop.

Closer to the core, downtown Odessa features historic residential pockets and modern apartment buildings near local cafes, while semi-rural areas like Gardendale provide acreage living on the northern edge of the metro.

Sources
Housing

Odessa features a divide between older mid-century ranch homes in central neighborhoods and modern multi-story apartment complexes and master-planned communities situated along outer corridors. Newer construction with resort-style amenities is concentrated around Parks Legado, Mission Estates, and along the John Ben Sheppard Parkway loop.

Housing availability and demand closely track the cycles of the regional oil economy, making lease timing a critical practical factor.

Sources
Getting around

Driving is essential for getting around Odessa, with major arteries including Andrews Highway, John Ben Sheppard Parkway, and the State Loop carrying heavy commuter traffic. Roads handle significant industrial and heavy-truck traffic tied to Permian Basin energy operations, leading locals to report aggressive driving habits and elevated accident rates.

Surface parking is generally abundant and easily accessible across medical centers and commercial corridors.

Sources
Food and dining

Odessa offers hearty Texas favorites and a strong Mexican food footprint alongside contemporary regional dining. Downtown gathering spots include Barrel and Derrick for refined Texas cuisine, Cafe San Blas for traditional breakfast, Southern Maid on 8th Street for morning donuts, and Masa Bakery paired with Home Brew Coffee.

Across town, local mainstays include Cork & Pig Tavern, Red Oak Kitchen for wood-fired plates, Twister Tacos, and long-standing barbecue spots like KD's Bar-B-Q.

Sources
Outdoors

Outdoor recreation centers around Comanche Trail Park and adjacent McKinney Park, which provide walking trails, fishing lakes, shaded picnic pavilions, and multi-use green spaces. Golf enthusiasts utilize local courses such as Ratliff or nearby Hogan, while families frequent Green Acres for outdoor mini golf and go-karts.

Beyond municipal parks, outdoor life is shaped by expansive desert horizons and striking West Texas evening sunsets.

Sources
Arts and culture

Odessa is defined by its legendary high school football tradition centered at Ratliff Stadium, celebrated in 'Friday Night Lights.' The city's performing arts scene is anchored by the Globe of the Great Southwest—an authentic replica of Shakespeare's Globe Theatre—along with the Permian Playhouse and live shows at the historic Ector Theatre. Other notable cultural landmarks include the Ellen Noël Art Museum, downtown public murals, hockey matches at Ector County Coliseum, the annual Sandhills Stock Show and Rodeo, and an accurate Stonehenge replica on the University of Texas Permian Basin campus.

Sources
Seasons and weather

The Permian Basin climate is arid and sun-drenched, bringing prolonged summer heat with temperatures regularly climbing well into the 90s. Springtime frequently features dry, blustery conditions and sudden dust storms that sweep across the open plains.

Winters remain exceptionally mild and predominantly dry, with freezing weather passing quickly and annual snowfall typically amounting to less than an inch.

Sources
For families

Public schooling is administered by the Ector County Independent School District, which operates roughly three dozen traditional, magnet, and alternative campuses. Families also have access to public charter schools like Compass Academy and Harmony Science Academy, alongside parochial institutions including St. Mary's Central Catholic School and Sherwood Christian Academy.

Safe suburban pockets with popular family amenities are situated around Andrews Highway, East Hillman Road, and the eastern master-planned subdivisions.

Sources
What locals say

Residents appreciate the strong employment base in healthcare and energy along with the welcoming, unpretentious West Texas community spirit. However, newcomers frequently struggle with the stark desert landscape, windblown dust and litter, and intense industrial activity.

Community discussions also voice concerns regarding reckless driving on regional roadways and housing that can feel underwhelming relative to expectations during economic upswings.

Sources

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