95 nursing jobs in San Luis Obispo, CA
Framed by volcanic morros like Bishop Peak and the Pacific coast, San Luis Obispo offers nurses a restorative Central Coast pace. Decompress hiking Cerro San Luis or grabbing tri-tip at the Thursday night farmers' market. With living costs about 9% above the national average, SLO pairs clinical career growth with unhurried coastal living.
Find a nursing job in San Luis Obispo
Hiring here: Adventist Health (47) · Wellpath (8) · CommonSpirit Health (4) · French Hospital Medical Center (4) · HealthForce Healthcare (3) · Dignity Health (2)
Oncology Hematology Nurse Practitioner
San Luis Obispo, CA · Posted 4 days ago
$144–$214/hr
- NP
- Day shift
- CNA
- RN
Founding Department Chair and Program Director Nursing CA, Open Rank
$116,000–$210,000/year
- DNP/RN
- Day shift
- Sign-on bonus
- RN
- Day shift
- RN
- Day shift
- Travel contract
- RN
- Per diem
- RN
- Per diem
- NP
- Day shift
- Per diem
Registered Nurse
$40–$56/hr
- New grads welcomed · reported
- RN
- Flexible shifts including mornings, evenings, weekends, and holidays
- Outpatient Dialysis
- RN
- Travel contract
Registered Nurse RN Management
$2,498/week
- RN
- 12-hour rotating
- Travel contract
Travel L&D RN - Labor & Delivery Registered Nurse
$2,608–$2,661/week
- RN
- 3x12 Nights
- Travel contract
Travel Registered Nurse PCU Job
$1,998/week
- RN
- 12-hour nights
- Travel contract
LVN - San Luis Obispo, CA
$45–$47/hr
- LVN
- AM 6am - 230pm, PM 2pm - 1030pm or NOC 10pm to 630am
- Travel contract
Registered Nurse – Telemetry - Travel - (Tele RN)
$1,963–$2,064
- RN
- 12-hour nights
- Travel contract
ICU RN
$1,844–$1,962/week
- RN
- Travel contract
- CEU allowance
- RN/CNA
- Night shift
Labor & Delivery RN
$52–$77/hr
- RN
- Night shift
- Labor and Delivery Nursing
Travel Registered Nurse ER Job
$2,155–$2,260/week
- RN
- 12-hour days
- Emergency Department
Registered Nurse RN Management
$2,873/week
- RN
- 8-hour rotating
- Travel contract
Travel Registered Nurse Endoscopy Job
$2,636/week
- RN
- 10-hour rotating
- Travel contract
LVN - San Luis Obispo, CA
$45–$47/hr
- LVN
- 8-hour nights
- Travel contract
- RN/CNA
- Day shift
Travel Registered Nurse OR Job
$2,576/week
- RN
- 8-hour days
- Travel contract
- RN/CNA
- Day shift
- Per diem
Adventist Health
6 open roles
Adventist Health
6 open roles
- RN/CNA
- Day shift
Certified Nursing Assistant (SEIU), Full Time, Night Shift
San Luis Obispo, CA · Closes Fri
$26/hr
$25–$27/hr
- CNA
- Night shift
- RN/CNA
- Night shift
RN II - OR, Full-Time, Rotating Shift (Mandatory call) (CNA)
San Luis Obispo, CA · Posted last week
$68/hr
$52–$84/hr
- RN/CNA
- Rotating shift
- RN/CNA
- Night shift
RN II-L&D (Mandatory Call), Per Diem, Day Shift (CNA)
San Luis Obispo, CA · Closing date passed
$68/hr
$52–$84/hr
- RN/CNA
- Day shift
- Per diem
Working and living in San Luis Obispo
· 95 open roles
Living costs
- Median gross rent
- $1,965/mo
- Rent and tenant-paid utilities
- Median household income
- $73,685/yr
- All local households, not nurse pay
New to our board this week
9 current postings first appeared here in the past seven days.
Credentials accepted
- DNP1
- NP3
- RN78
- LPN1
- LVN6
- CNA37
One posting may accept more than one credential.
Shifts listed
- Nights31
- Days25
- Rotating12
- per-diem8
Postings may list several shifts or leave the shift unspecified.
Living in San Luis Obispo
San Luis Obispo is a compact Central Coast college town between volcanic peaks and wine country, halfway from L.A. to San Francisco on Highway 101. Cal Poly keeps the median age near 30 and downtown—Higuera Street, the 1772 Mission, Bubblegum Alley, Scout Coffee, Firestone Grill—alive, especially at Thursday’s Farmers Market.
More about life hereShow less
Bishop Peak, Laguna Lake, Montana de Oro, and the Nine Sisters make after-shift hikes realistic; Avila and Pismo are close, if chilly. Edna Valley vineyards start at the city’s edge.
Housing is the shock: median homes near $900,000–$953,000 and one-bedroom rents from the high $1,800s to about $3,000. Downtown is walkable but noisy with tight parking; Laguna Lake and Foothill trade convenience for trails; the East Side plus Arroyo Grande or Pismo (25–30 minutes) stretch a budget further. In-town commutes average about 13 minutes, yet SLO is somewhat isolated, restaurants close early, and locals flag a thinner job market and healthcare challenges.
Weather consoles: about 285 sunny days, August highs near 80°F, winter nights around 50°F.
Sources
Neighborhoods
Downtown San Luis Obispo is the walkable core—restaurants, shops, nightlife, historic homes, and a short hop to Cal Poly—with higher prices, noise, activity, and limited parking. Laguna Lake is a popular suburban residential pocket known for parks, open space, and trail access; it suits people who want nature nearby but accept more driving and weaker walkability to downtown.
Bishop Peak and the Foothill area are quieter, view-oriented neighborhoods of established homes with direct hiking access, limited inventory, and mixed home ages and conditions. SLO’s East Side is framed as family-friendly with more entry-level stock for first-time buyers; the Cal Poly/West University area is campus-adjacent; Los Ranchos/Edna Valley leans toward vineyard acreage and luxury estates (airport/air traffic is a factor on that south side).
Nearby Pismo Beach and Arroyo Grande are the usual “somewhat more affordable” alternatives, about a 25–30 minute commute into SLO.
Sources
Housing
Housing is the budget-breaker. U.S. News lists a median home value of $898,981 and median rent of $1,836; Apartment Guide (2024) cites a median sale price around $953,000 and average rent of $3,000 for a one-bedroom.
Downtown is the premium, walkable tier; the East Side is the usual entry-level/family stock; Foothill and Laguna Lake are established residential; Los Ranchos/Edna Valley is acreage and luxury among vineyards. Pismo Beach and Arroyo Grande are the nearby “somewhat affordable” overflow.
Limited supply, sellers not under pressure, and sticker shock versus most of the country are the market’s personality; within California it can look less extreme than Los Angeles or the Bay Area. Median household income is $78,523, so an $80k–$150k nurse wage sits at or above typical local households while still stretching hard against those home prices.
Getting around
U.S. News reports an average San Luis Obispo commute of about 13.29 minutes, reflecting a compact city rather than a long suburban grind. Downtown living buys that convenience at the cost of limited parking; Laguna Lake and similar residential areas mean more driving for errands and nightlife.
Relocators commonly live in Pismo Beach or Arroyo Grande and budget 25–30 minutes into SLO. Highway 101 is the county spine; San Luis Obispo’s airport and associated air traffic sit toward Edna Valley.
Sources do not name hospital campuses, transit lines, or shift-parking rules, so expect a car-first pattern outside the downtown core.
Food and dining
Downtown—especially Higuera Street—is the everyday food district: pedestrian shopping, restaurants, and coffee with college-town energy. Named local stops include Firestone Grill and Giovanni’s for casual meals, Wayward Bakery and Yokoso Coffee, plus student/local cafes Scout Coffee and Kreuzberg California.
Thursday evenings the Downtown SLO Farmers Market takes over with food vendors, produce, live music, and a civic crowd that doubles as a weekly dinner plan. Edna Valley, Arroyo Grande, and Paso Robles add tasting rooms just outside town.
A practical con for hospital shifts: locals say restaurants close early, so true late-night options are thin compared with a larger city.
Outdoors
Outdoor life is the city’s main amenity: more than 50 parks, volcanic Nine Sisters peaks running toward Morro Bay, and trailheads inside town. Bishop Peak is the signature hike with city views; Laguna Lake offers parks and open space; Montana de Oro State Park and Pismo Preserve are the big coastal hiking days.
Avila Beach and Pismo Beach sit a short drive away (a creek runs from SLO toward Avila); the county markets about 80 miles of beaches. Edna Valley vineyards start at the south edge; elephant seals are a San Simeon outing.
Hiking and mountain biking are year-round in the mild climate.
Arts and culture
Mission San Luis Obispo de Tolosa, founded in 1772, still holds daily mass; volunteers ring the bells at noon and 6 p.m. Downtown mixes Spanish Colonial and Victorian buildings with Bubblegum Alley, the San Luis Obispo Museum of Art (SLOMA), the Children’s Museum, and the historic Fremont Theater for film and live performance.
Thursday’s Farmers Market is the weekly civic ritual; an emerging arts scene, galleries, and college-town energy fill the rest of the calendar. SLO is the gateway to more than 250 wineries across Edna Valley, Arroyo Grande, and Paso Robles.
Nightlife exists but is not a late-night metropolis. The city has committed to carbon neutrality by 2035 and installed nearly 200 EV charging stations.
Seasons and weather
The climate is Mediterranean and a primary reason people move here. A local realtor filming in August cited highs around 81°F and December/January lows around 48–50°F; Apartment Guide lists an average summer high of 79°F and about 285 days of sunshine.
It is sunny nearly every day without inland-California heat. Coastal beaches can still feel chilly even when town is pleasant, which is the main seasonal surprise for newcomers used to warm water.
For families
About 47,000–48,900 people live in the city (metro over 280,000), with a median age of 29.7 pulled down by Cal Poly, so the texture is college-town plus families rather than a retiree enclave. The East Side is explicitly described as family-friendly with more entry-level homes; Laguna Lake is the suburban, parks-and-trails balance.
Downtown has the San Luis Obispo Children’s Museum, the Mission, and Thursday Farmers Market; the city claims more than 50 parks. Sources do not name school districts, ratings, or childcare waitlists, so those need a separate local check.
What locals say
People describe SLO as charming, temperate, and unusually balanced—a college town that still feels family-friendly and “just right”—and Visit California notes National Geographic and Oprah branded it the happiest city in the country. Reddit and relocators are blunter: it is expensive, somewhat isolated, semi-rural around the edges, with easy nature access and a beautiful but chilly nearby beach.
A Central Coast realtor who grew up in the county flags restaurants that close early, high property prices, thinner job opportunities, and some healthcare-system challenges. Sticker shock versus the rest of the country is common; compared with the LA–Bay Area corridor the same market can feel a bit less extreme, but limited supply and unhurried sellers still make buying slow and selective.