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18 nursing jobs in Orangeburg, SC

Known as "The Garden City," Orangeburg sits along the Edisto River in South Carolina's Midlands. Edisto Memorial Gardens showcases thousands of roses each spring. This close-knit community offers a relaxed pace and Southern charm for nurses seeking a quieter lifestyle outside major metro areas.

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Palmetto Nephrology, PA workplace
Palmetto Nephrology, PA — a workplace named in a current Orangeburg postingView Palmetto Nephrology, PA →

Find a nursing job in Orangeburg

Hiring here: ATC Healthcare Services of Georgia (4) · Centerwell (2) · Edisto Post Acute (2) · Veterans Health Administration (2) · American Traveler (1) · CNSCares (1)

Palmetto Nephrology, PA logo

Palmetto Nephrology, PA

Orangeburg, SC

Nurse Practitioner

$98,000–$128,000/year

  • NP
  • Rotating shift
1 / 2
  • RN
  • 8-⁠hour 8 hour

The Oaks Post Acute

Orangeburg, SC

RN

Posted 4 days ago

$36–$40/hr

  • RN
Centerwell logo

Centerwell

Orangeburg, SC

  • LPN

Veterans Health Administration

Orangeburg, SC · Health system employer

Practical Nurse

$41,000–$75,000/year

  • RN
MUSC Health logo

MUSC Health

Orangeburg, SC · Health system employer

  • RN
  • 8-⁠hour days
  • Compact license OK
DaVita Kidney Care logo

DaVita Kidney Care

Orangeburg, SC

  • RN
  • Flexible shifts including mornings, evenings, weekends, and holidays
  • ADN accepted
Fresenius Medical Care logo

Fresenius Medical Care

Orangeburg, SC

  • New grads welcomed
  • RN
  • Floating required

CNSCares

Orangeburg, SC

  • RN
  • Day shift
  • Agency contract

Edisto Post Acute

Orangeburg, SC

  • RN/LPN/LVN
  • 7:00 PM – 11:00 PM
  • CEU allowance
American Traveler logo

American Traveler

Orangeburg, SC · Staffing partner

Travel RN - GI/Endoscopy

Posted last week

$1,910/week

  • RN
  • Travel contract
ATC Healthcare Services of Georgia logo

ATC Healthcare Services of Georgia

Orangeburg, SC · Staffing partner

  • RN
  • 10-⁠hour days
  • Travel contract
Centerwell logo

Centerwell

Orangeburg, SC

  • RN
  • ADN accepted

Veterans Health Administration

Orangeburg, SC · Health system employer

  • RN
  • Day shift
  • ADN accepted

Edisto Post Acute

Orangeburg, SC

RN 7p-11p

From $34/hr

  • RN/LPN
  • Night shift
  • CEU allowance

ATC Healthcare Services of Georgia

3 open roles · day & night shifts · Travel

Endoscopy

Orangeburg, SC

Up to $2,059/week

  • RN
  • 8-⁠hour days
  • Travel contract

ER Emergency Room

Orangeburg, SC

$1,938/week

  • RN
  • 12-⁠hour nights
  • Travel contract

ER Emergency Room

Orangeburg, SC

$1,938/week

  • RN
  • 12-⁠hour nights
  • Travel contract

Working and living in Orangeburg

· 18 open roles

Living costs

Median gross rent
$848/mo
Rent and tenant-paid utilities
Median household income
$38,635/yr
All local households, not nurse pay

Census ACS 2024

Open to new grads

1 postings explicitly welcome new grads.

Browse new grad roles

New to our board this week

1 current postings first appeared here in the past seven days.

Browse current openings

Credentials accepted

  • NP1
  • RN16
  • LPN3
  • LVN1

One posting may accept more than one credential.

Shifts listed

  • Days5
  • Nights3
  • Evenings1
  • Rotating1
  • per-diem1

Postings may list several shifts or leave the shift unspecified.

Living in Orangeburg

Known as 'The Garden City,' Orangeburg offers relocating nurses a relaxed Lowcountry-adjacent pace grounded by Claflin University and South Carolina State University.

More about life here

Life here centers on established Southern traditions, from springtime strolls through the 175-acre Edisto Memorial Gardens during the Orangeburg Festival of Roses to meals at long-standing favorites like Duke's BBQ and Chestnut Grill. Healthcare staff benefit from stress-free commutes averaging under a quarter of an hour, avoiding the intense gridlock seen in larger metropolitan centers.

The rental and housing market consists mainly of traditional brick ranch homes and quiet mid-century subdivisions in surrounding areas like Brookdale and Edisto. However, the tradeoffs require realistic expectations: nighttime entertainment and specialty retail are scarce, and certain parts of the city face elevated crime concerns.

With Columbia only 37 miles away and Charleston an easy drive down Interstate 26, Orangeburg works best for nurses who appreciate a quiet, home-centered routine while leaning on nearby cities for expansive nightlife and weekend escapes.

Sources
As of Sep 16, 2026
Neighborhoods

Relocating healthcare workers often look at residential pockets surrounding Claflin University and South Carolina State University, where established brick single-family homes sit along tree-lined streets. Nearby suburban communities such as Brookdale offer modest residential subdivisions, while the adjacent community of Edisto provides a quieter, small-town atmosphere preferred by those seeking more space.

Housing closer to the university corridors tends to cater to students and staff, whereas peripheral neighborhoods lean toward single-family dwellings and small rental communities.

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Housing

The local housing stock features a mix of traditional brick single-family detached homes, townhome developments, and modest low-rise apartment complexes. More central properties cater heavily to university students and faculty, while outlying sectors offer standalone houses on larger, wooded lots.

Renters and buyers will find classic Southern architecture along established streets, though newly constructed luxury apartment complexes are limited compared to larger metropolitan markets in the state.

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Getting around

Orangeburg is predominantly car-dependent, with local drivability facilitating typical commute times of roughly a quarter of an hour across town. The city sits approximately 37 miles southeast of Columbia along the North Fork of the Edisto River, allowing manageable highway travel for regional commuting.

Bikeability remains low, meaning shifts at local facilities rely almost exclusively on personal vehicles, though parking across local clinic and hospital campuses is generally straightforward and ample.

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Food and dining

The local dining scene revolves around classic Southern staples and long-standing mom-and-pop joints. Barbecue is a regional centerpiece, highlighted by Duke's BBQ on Whitman Street SE and nearby country outposts like Lone Star BBQ & Mercantile.

Other established local favorites include House of Pizza and The Barrel Room on Sims Street, along with Chestnut Grill, an enduring spot famous for its chicken salad. For fresh produce and artisan goods, the Downtown Orangeburg Farmers' Market serves as a seasonal community hub.

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Outdoors

Outdoor recreation centers along the North Fork of the Edisto River, anchored by the 175-acre Edisto Memorial Gardens, which showcases blooming azaleas and thousands of rose varieties along waterfront boardwalks. For active recreation, the Orangeburg Aquatic Park features splash grounds and a lazy river during the summer months.

Residents also take advantage of river paddling, fishing, and day trips to regional spots like Paris Mountain State Park near Greenville for trail hiking and lake outings.

Sources
Arts and culture

Orangeburg's cultural identity is deeply rooted in its status as home to two historically Black institutions, South Carolina State University and Claflin University, which bring collegiate athletics, homecoming events, and academic programming. The city hosts the annual Orangeburg Festival of Roses each spring at Edisto Memorial Gardens.

Arts and local history are reflected in venues like the Bluebird Theatre on Russell Street, the Williams Civil Rights Museum, and boutique artisan retail at Five Rivers Market.

Sources
Seasons and weather

The local climate features long, humid summers with average highs reaching the low to mid-seventies year-round on average and peak summer days seeing intense heat. Winters are exceptionally mild, eliminating heavy snowfall and severe freezes.

Rainfall averages around 47 inches annually, and incoming residents should be prepared for coastal storm systems during Atlantic hurricane season, as well as high pollen levels and active outdoor insects through the extended warm season.

Sources
For families

Public education is served by local institutions including Brookdale Elementary, Whittaker Elementary, and Edisto Elementary. Family amenities include the Orangeburg Aquatic Park and nature walks along Edisto Memorial Gardens.

Parents evaluating the area frequently weigh public school quality ratings and safety variations between neighborhoods, with some families choosing calmer outlying residential communities like Edisto or Brookdale to secure a more suburban setting.

Sources
What locals say

Residents describe Orangeburg, locally nicknamed 'The Burg,' as a proud Southern college town with a slow pace of life and deep community ties. Locals appreciate the central location that makes day trips to Columbia, Charleston, and coastal spots accessible.

However, community discussions frequently highlight sharp drawbacks, including noticeable crime in specific sections of town, limited entertainment, and a sparse nightlife and dining scene that leads many residents to travel elsewhere for weekend leisure.

Sources

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