41 nursing jobs in Spartanburg, SC
Positioned at the I-85 and I-26 junction, the 'Hub City' pairs straightforward regional commutes with a cost of living about 9% below the national average. Trade shifts for live shows at downtown’s FR8yard by Morgan Square, bike the Mary Black Rail Trail, or settle into newer homes in Boiling Springs near Lake Bowen.
Find a nursing job in Spartanburg
Hiring here: Spartanburg Regional Healthcare System (12) · 110 Prisma Health-Upstate (2) · Magnolia Manor of Spartanburg (2) · ReGenesis Health Care (2) · Veterans in Healthcare (2) · White Oak Management, Inc. (2)
WE Prem LPN
$29–$37/hr
- LPN
- 12-hour weekends only
- +$8/hr differential
Licensed Practical Nurse (LPN) – Float
$25–$31/hr
- Sign-on bonus
- LPN
- Day shift
- CEU allowance
RN Restorative/Safety/TX
$34–$39/hr
- New grads welcomed · reported
- RN
- Day shift
Licensed Practical Nurse LPN
$30–$35/hr
- LPN
- 12-hour shifts
- Tuition reimbursement
LPN/RN (Thur/Fri/Sat 7P-7A)
$28–$36/hr
- RN/LPN
- 12-hour nights
- +$3/hr differential
Weekend Staffing Team Registered Nurse-Level 2- PV4
Posted 5 days ago
- RN
- Sign-on bonus
- RN
- 12-hour days
- Compact license OK
- Sign-on bonus
- RN
- 12-hour shifts
WE Prem LPN/RN
$28–$36/hr
- RN/LPN
- Every Saturday and Sunday | 7:00 AM – 7:00 PM
- +$8/hr differential
LPN/RN (Thur/Fri/Sat 7P-7A)
$28–$36/hr
- RN/LPN
- 12-hour nights
- +$3/hr differential
Registered Nurse
Posted 2 weeks ago
- RN
- Travel contract
- NP
- Per diem
- Tuition reimbursement
- LPN
- Tuition reimbursement
Registered Nurse (RN) Outpatient, Oncology Infusion, FT, Day
Posted last week
- RN
- Day (United States of America)
- Outpatient Oncology Infusion-CISp
Licensed Practical Nurse
$41,000–$75,000/year
- RN
- Day shift
- RN
- 12-hour nights
- Travel contract
Travel RN - Home Health
$2,086/week
- RN
- Ratio 1:5
- 8-hour days
Licensed Practical Nurse (LPN)
$25–$31/hr
- Sign-on bonus
- LPN
- Day shift
- CEU allowance
Registered Nurse RN
$38/hr
- Sign-on bonus
- RN
- Night shift
- Tuition reimbursement
- Sign-on bonus
- RN
- Day shift
- Compact license OK
Registered Nurse (RN) - Outpatient, Surgery Center, PT, Days
Posted last week
- RN
- Day (United States of America)
- Operating Room
Spartanburg Regional Healthcare System
11 open roles
Spartanburg Regional Healthcare System
11 open roles
Weekend Staffing Team-RN Level II
Spartanburg, SC · Posted last week
- New grads welcomed
- RN
- Weekend shift
- Compact license OK
Clinical RN II (FT Nights)- Emergency Dept
Spartanburg, SC · Posted last week
- RN
- FT Nights
- Compact license OK
Registered Nurse (RN)- 5 Main
Spartanburg, SC · Posted last week
- Sign-on bonus
- RN
- Day shift
- Compact license OK
Nurse-Employee Health
Spartanburg, SC
- RN
- ADN accepted
Registered Nurse-Ortho Trauma
Spartanburg, SC
- New grads welcomed
- RN
- Orthopedic Trauma unit
Nurse-Clinic
Spartanburg, SC
- RN
Registered Nurse PRN Tier (RN) 1- SMC Emergency Center
Spartanburg, SC
- New grads welcomed
- RN
- Per diem
- Compact license OK
PRN Registered Nurse (RN)- Behavioral Health
Spartanburg, SC
- RN
- Per diem
- Compact license OK
Registered Nurse (RN) - Nursery Intensive (NICU)
Spartanburg, SC
- RN
- RN
- Ratio 1:5
- Night shift
RN-Clinical Resource Pool L1
Spartanburg, SC · Posted last week
- RN
- Floating required
Working and living in Spartanburg
· 41 open roles
Posted hourly pay
- RN
- $31/hr median
- $28–$34/hr middle half · 8 postings
- LPN
- $28/hr median
- $28–$29/hr middle half · 8 postings
Living costs
- Median gross rent
- $1,099/mo
- Rent and tenant-paid utilities
- Median household income
- $51,964/yr
- All local households, not nurse pay
New to our board this week
2 current postings first appeared here in the past seven days.
Credentials accepted
- NP2
- RN32
- LPN10
One posting may accept more than one credential.
Shifts listed
- Days12
- per-diem8
- Nights6
- Rotating2
- weekend2
Postings may list several shifts or leave the shift unspecified.
Living in Spartanburg
Known historically as the 'Hub City,' Spartanburg is defined by its strategic Upstate location where Interstate 85 and Interstate 26 intersect.
More about life hereShow less
For relocating nurses, this positioning delivers an easy drive to regional healthcare employers alongside straightforward day trips into Greenville or Charlotte. The city center has transformed through significant downtown investment, spotlighted by minor league baseball at Fifth Third Park, live bands at FR8yard, and seasonal gatherings like Hub City Hog Fest on Morgan Square.
Residential life varies from urban apartments near Chapman Cultural Center to established family tracts in Boiling Springs and Inman near Lake Bowen. Outdoor access is woven throughout the city via the Mary Black Rail Trail, Cottonwood Trail, and expansive hiking at Camp Croft State Park.
Tradeoffs require clear eyes: public transit is minimal, necessitating a reliable vehicle to navigate daily shifts, and localized crime rates make neighborhood selection critical. Summer humidity and heavy spring pollen are standard, but the welcoming social fabric and lower barrier to entry make Spartanburg a practical Upstate landing pad.
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Neighborhoods
Downtown Spartanburg offers walkable urban living near Morgan Square and the Chapman Cultural Center, appealing to professionals who want quick access to local dining and venues. Boiling Springs and Inman sit to the north, offering suburban subdivisions, newer construction, and access to Lake Bowen.
Greer straddles the county line toward Greenville, serving as a popular enclave for commuters seeking established neighborhoods and easy travel along regional thoroughfares.
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Housing
Housing options range from older mill-era homes and historic properties with mature tree canopies to modern master-planned communities featuring HOA oversight. Downtown offers loft-style apartments and condominiums within walking distance of retail, whereas communities further north in Inman and Boiling Springs skew toward detached single-family new construction with larger yards.
Budget-conscious buyers often look toward these developing northern enclaves, while established golf-course communities and custom builds command a premium.
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Getting around
Spartanburg is heavily car-dependent, with public transportation options strictly limited across the county. Commuters rely primarily on Interstate 85 and Interstate 26, which form the primary transportation spine through the Upstate and link local medical centers to surrounding suburbs.
While travel times are generally manageable compared to larger metros, arterial corridors experience light-heavy traffic patterns and growing-pains congestion during morning and evening shift changes.
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Food and dining
The culinary footprint centers around downtown's Morgan Square and Main Street, featuring chef-driven dining alongside casual mainstays like the Blue Moon. Little River Coffee Bar pairs with the Hub City Bookshop for daytime caffeine, while FR8yard operates as an open-air biergarten serving craft beer and casual street fare.
The downtown district makes it easy to move between casual quick-service spots, specialty burger bars, and cocktail lounges within a few walkable blocks.
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Outdoors
Outdoor enthusiasts frequent the Mary Black Rail Trail and the Cottonwood Trail inside the Edwin M. Griffin Nature Preserve for running and biking. Camp Croft State Park provides wooded hiking, equestrian trails, and camping south of the city center.
Boating, paddle sports, and lakeside relaxation are anchored to the north at Lake Bowen, while Hatcher Garden and Woodland Preserve offers quiet walking paths through curated botanical displays.
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Arts and culture
Spartanburg offers a lively calendar centered around Fifth Third Park, where minor league baseball team the Hub City Spartanburgers plays in a new downtown stadium. The Chapman Cultural Center anchors the visual and performing arts community, complemented by the Spartanburg Art Museum and the city's new planetarium.
Downtown comes alive with community events like the annual spring Hub City Hog Fest barbecue competition, boutique bowling at Underpin Lanes 'N Lounge, and free seasonal concerts at Music on Main.
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Seasons and weather
Summer brings intense heat paired with heavy Southern humidity that pushes home cooling demands up significantly. Spring arrives with warm temperatures accompanied by an aggressive tree pollen season across the Upstate.
Winters are generally mild with infrequent freeze events, making outdoor activities feasible year-round aside from midsummer peak heat hours.
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For families
Families gravitate toward Boiling Springs and Inman due to their established public schools, youth sports options, and proximity to recreation at Lake Bowen. Downtown hosts educational outings like The Children's Museum of the Upstate satellite location, SPARK Space maker workshops at the county library, and the Hub City Railroad Museum.
Community educational support extends into higher ed, with Spartanburg Community College providing targeted tuition-free career programs for local residents.
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What locals say
Residents praise Spartanburg's lower cost of living, friendly community networking groups, and strategic position for day trips to Greenville or Charlotte. However, locals candidly note that safety and street character vary sharply block by block, with notable pockets of property and violent crime.
Other frequent complaints include patchy sidewalk infrastructure outside the core and local resistance to rapid suburban development.