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41 nursing jobs in Spartanburg, SC

Positioned at the I-85 and I-26 junction, the 'Hub City' pairs straightforward regional commutes with a cost of living about 9% below the national average. Trade shifts for live shows at downtown’s FR8yard by Morgan Square, bike the Mary Black Rail Trail, or settle into newer homes in Boiling Springs near Lake Bowen.

Spartanburg, SC on the map· Open the live map
White Oak Management, Inc. workplace
White Oak Management, Inc. — a workplace named in a current Spartanburg postingView White Oak Management, Inc. →

Find a nursing job in Spartanburg

Hiring here: Spartanburg Regional Healthcare System (12) · 110 Prisma Health-Upstate (2) · Magnolia Manor of Spartanburg (2) · ReGenesis Health Care (2) · Veterans in Healthcare (2) · White Oak Management, Inc. (2)

White Oak Management, Inc.

Spartanburg, SC

WE Prem LPN

$29–$37/hr

  • LPN
  • 12-⁠hour weekends only
  • +$8/hr differential

White Oak Management, Inc.

Spartanburg, SC

  • LPN
  • Per diem

ReGenesis Health Care

Spartanburg, SC

  • Sign-on bonus
  • LPN
  • Day shift
  • CEU allowance
Charles Lea Center logo

Charles Lea Center

Spartanburg, SC

LPN/RN Nurse

$30–$32/hr

  • LPN
  • Rotating shift
  • Tuition reimbursement
National Health - WHITE OAK LLC logo

National Health - WHITE OAK LLC

Spartanburg, SC

  • New grads welcomed · reported
  • RN
  • Day shift
Senior Helpers logo

Senior Helpers

Spartanburg, SC

  • RN
  • CEU allowance

Magnolia Manor of Spartanburg

Spartanburg, SC

  • LPN
  • 12-⁠hour shifts
  • Tuition reimbursement
White Oak Estates logo

White Oak Estates

Spartanburg, SC

  • RN/LPN
  • 12-⁠hour nights
  • +$3/hr differential
Spartanburg Regional Healthcare System logo

Spartanburg Regional Healthcare System

Spartanburg, SC · Health system employer

  • RN
Veterans in Healthcare logo

Veterans in Healthcare

Spartanburg, SC

  • Sign-on bonus
  • RN
  • 12-⁠hour days
  • Compact license OK

Physical Rehabilitation and Wellness Center

Spartanburg, SC

Registered Nurse RN

Posted 2 days ago

$38/hr

  • Sign-on bonus
  • RN
  • 12-⁠hour shifts

Healthcare employer

Spartanburg, SC

WE Prem LPN/RN

$28–$36/hr

  • RN/LPN
  • Every Saturday and Sunday | 7:00 AM – 7:00 PM
  • +$8/hr differential

Healthcare employer

Spartanburg, SC

  • RN/LPN
  • 12-⁠hour nights
  • +$3/hr differential

Top Home Care Solutions of South Carolina

Spartanburg, SC

Registered Nurse

Posted 2 weeks ago

  • RN
  • Travel contract

State of South Carolina

Spartanburg, SC

  • NP
  • Per diem
  • Tuition reimbursement
BioLife Plasma Services logo

BioLife Plasma Services

Spartanburg, SC

  • LPN
  • Tuition reimbursement
ACG Hospice logo

ACG Hospice

Spartanburg, SC

  • RN
  • Tuition reimbursement
SCA Health logo

SCA Health

Spartanburg, SC

  • RN

Maxim Healthcare Services Direct

Spartanburg, SC

1.1 School RN

$30–$34/hr

  • RN

Gentiva Hospice

Spartanburg, SC

Hospice Registered Nurse

Posted last week

  • RN
  • Per diem

110 Prisma Health-Upstate

Spartanburg, SC

  • RN
  • Day (United States of America)
  • Outpatient Oncology Infusion-CISp
Davita logo

Davita

Spartanburg, SC

  • RN
  • Rotating shift
  • ADN accepted

Veterans Health Administration

Spartanburg, SC · Health system employer

Licensed Practical Nurse

$41,000–$75,000/year

  • RN
  • Day shift
ATC Healthcare Services of Georgia logo

ATC Healthcare Services of Georgia

Spartanburg, SC · Staffing partner

  • RN
  • 12-⁠hour nights
  • Travel contract
American Traveler logo

American Traveler

Spartanburg, SC · Staffing partner

  • RN
  • Ratio 1:5
  • 8-⁠hour days

ReGenesis Health Care

Spartanburg, SC

  • Sign-on bonus
  • LPN
  • Day shift
  • CEU allowance

Magnolia Manor of Spartanburg

Spartanburg, SC

  • Sign-on bonus
  • RN
  • Night shift
  • Tuition reimbursement

Spartanburg Regional Healthcare System

Spartanburg, SC · Health system employer

  • Sign-on bonus
  • RN
  • Day shift
  • Compact license OK
Veterans in Healthcare logo

Veterans in Healthcare

Spartanburg, SC

  • NP
  • 12-⁠hour days

110 Prisma Health-Upstate

Spartanburg, SC

  • RN
  • Day (United States of America)
  • Operating Room

Spartanburg Regional Healthcare System

11 open roles

Weekend Staffing Team-RN Level II

Spartanburg, SC · Posted last week

  • New grads welcomed
  • RN
  • Weekend shift
  • Compact license OK

Clinical RN II (FT Nights)- Emergency Dept

Spartanburg, SC · Posted last week

  • RN
  • FT Nights
  • Compact license OK

Registered Nurse (RN)- 5 Main

Spartanburg, SC · Posted last week

  • Sign-on bonus
  • RN
  • Day shift
  • Compact license OK

Nurse-Employee Health

Spartanburg, SC

  • RN
  • ADN accepted
  • New grads welcomed
  • RN
  • Orthopedic Trauma unit

Nurse-Clinic

Spartanburg, SC

  • RN
  • New grads welcomed
  • RN
  • Per diem
  • Compact license OK
  • RN
  • Per diem
  • Compact license OK

RN-Clinical Resource Pool L1

Spartanburg, SC · Posted last week

  • RN
  • Floating required

Working and living in Spartanburg

· 41 open roles

Posted hourly pay

RN
$31/hr median
$28–$34/hr middle half · 8 postings
LPN
$28/hr median
$28–$29/hr middle half · 8 postings

See roles with listed pay

Living costs

Metro price level
91.1 (100 = national)
BEA 2024
Median gross rent
$1,099/mo
Rent and tenant-paid utilities
Median household income
$51,964/yr
All local households, not nurse pay

Census ACS 2024

Open to new grads

7 postings explicitly welcome new grads.

Browse new grad roles

New to our board this week

2 current postings first appeared here in the past seven days.

Browse current openings

Credentials accepted

  • NP2
  • RN32
  • LPN10

One posting may accept more than one credential.

Shifts listed

  • Days12
  • per-diem8
  • Nights6
  • Rotating2
  • weekend2

Postings may list several shifts or leave the shift unspecified.

Living in Spartanburg

Known historically as the 'Hub City,' Spartanburg is defined by its strategic Upstate location where Interstate 85 and Interstate 26 intersect.

More about life here

For relocating nurses, this positioning delivers an easy drive to regional healthcare employers alongside straightforward day trips into Greenville or Charlotte. The city center has transformed through significant downtown investment, spotlighted by minor league baseball at Fifth Third Park, live bands at FR8yard, and seasonal gatherings like Hub City Hog Fest on Morgan Square.

Residential life varies from urban apartments near Chapman Cultural Center to established family tracts in Boiling Springs and Inman near Lake Bowen. Outdoor access is woven throughout the city via the Mary Black Rail Trail, Cottonwood Trail, and expansive hiking at Camp Croft State Park.

Tradeoffs require clear eyes: public transit is minimal, necessitating a reliable vehicle to navigate daily shifts, and localized crime rates make neighborhood selection critical. Summer humidity and heavy spring pollen are standard, but the welcoming social fabric and lower barrier to entry make Spartanburg a practical Upstate landing pad.

Sources
As of Sep 16, 2026
Neighborhoods

Downtown Spartanburg offers walkable urban living near Morgan Square and the Chapman Cultural Center, appealing to professionals who want quick access to local dining and venues. Boiling Springs and Inman sit to the north, offering suburban subdivisions, newer construction, and access to Lake Bowen.

Greer straddles the county line toward Greenville, serving as a popular enclave for commuters seeking established neighborhoods and easy travel along regional thoroughfares.

Sources
Housing

Housing options range from older mill-era homes and historic properties with mature tree canopies to modern master-planned communities featuring HOA oversight. Downtown offers loft-style apartments and condominiums within walking distance of retail, whereas communities further north in Inman and Boiling Springs skew toward detached single-family new construction with larger yards.

Budget-conscious buyers often look toward these developing northern enclaves, while established golf-course communities and custom builds command a premium.

Sources
Getting around

Spartanburg is heavily car-dependent, with public transportation options strictly limited across the county. Commuters rely primarily on Interstate 85 and Interstate 26, which form the primary transportation spine through the Upstate and link local medical centers to surrounding suburbs.

While travel times are generally manageable compared to larger metros, arterial corridors experience light-heavy traffic patterns and growing-pains congestion during morning and evening shift changes.

Sources
Food and dining

The culinary footprint centers around downtown's Morgan Square and Main Street, featuring chef-driven dining alongside casual mainstays like the Blue Moon. Little River Coffee Bar pairs with the Hub City Bookshop for daytime caffeine, while FR8yard operates as an open-air biergarten serving craft beer and casual street fare.

The downtown district makes it easy to move between casual quick-service spots, specialty burger bars, and cocktail lounges within a few walkable blocks.

Sources
Outdoors

Outdoor enthusiasts frequent the Mary Black Rail Trail and the Cottonwood Trail inside the Edwin M. Griffin Nature Preserve for running and biking. Camp Croft State Park provides wooded hiking, equestrian trails, and camping south of the city center.

Boating, paddle sports, and lakeside relaxation are anchored to the north at Lake Bowen, while Hatcher Garden and Woodland Preserve offers quiet walking paths through curated botanical displays.

Sources
Arts and culture

Spartanburg offers a lively calendar centered around Fifth Third Park, where minor league baseball team the Hub City Spartanburgers plays in a new downtown stadium. The Chapman Cultural Center anchors the visual and performing arts community, complemented by the Spartanburg Art Museum and the city's new planetarium.

Downtown comes alive with community events like the annual spring Hub City Hog Fest barbecue competition, boutique bowling at Underpin Lanes 'N Lounge, and free seasonal concerts at Music on Main.

Sources
Seasons and weather

Summer brings intense heat paired with heavy Southern humidity that pushes home cooling demands up significantly. Spring arrives with warm temperatures accompanied by an aggressive tree pollen season across the Upstate.

Winters are generally mild with infrequent freeze events, making outdoor activities feasible year-round aside from midsummer peak heat hours.

Sources
For families

Families gravitate toward Boiling Springs and Inman due to their established public schools, youth sports options, and proximity to recreation at Lake Bowen. Downtown hosts educational outings like The Children's Museum of the Upstate satellite location, SPARK Space maker workshops at the county library, and the Hub City Railroad Museum.

Community educational support extends into higher ed, with Spartanburg Community College providing targeted tuition-free career programs for local residents.

Sources
What locals say

Residents praise Spartanburg's lower cost of living, friendly community networking groups, and strategic position for day trips to Greenville or Charlotte. However, locals candidly note that safety and street character vary sharply block by block, with notable pockets of property and violent crime.

Other frequent complaints include patchy sidewalk infrastructure outside the core and local resistance to rapid suburban development.

Sources

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